Abstract
Critical studies using mice infected experimentally with nematodes (Nematospiroides dubius, Nippostrongylus muris and Heterakis spumosa) have shown methyridine to be an extremely effective anthelmintic when administered orally or subcutaneously. Comparisons of the two treatment regimes show subcutaneous administration to be the more efficient in terms of absolute dose, but neither treatment has a significant advantage in therapeutic safety margin. Methyridine has a more uniform anthelmintic action than either phenothiazine or bephenium against adult forms of the three test nematodes. In addition the drug possesses activity against all stages of certain immature nematode infections.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- SMITH P. E. Life history and host-parasite relations of Heterakis spumosa, a nematode parasite in the colon of the rat. Am J Hyg. 1953 Mar;57(2):194–221. doi: 10.1093/oxfordjournals.aje.a119569. [DOI] [PubMed] [Google Scholar]