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British Journal of Pharmacology and Chemotherapy logoLink to British Journal of Pharmacology and Chemotherapy
. 1961 Dec;17(3):488–506. doi: 10.1111/j.1476-5381.1961.tb01136.x

Action of chlorothiazide on the distribution, excretion and hypotensive effect of pempidine in man

C T Dollery, D Emslie-Smith, D F Muggleton
PMCID: PMC1482097  PMID: 13887050

Abstract

When chlorothiazide is given to hypertensive patients who are receiving pempidine a rise in plasma pempidine concentration occurs and this is proportionately greater than the additional fall in blood pressure. After pempidine has been added to human whole blood in vitro or in vivo the ratio of the pempidine concentration in the red cells to that in the plasma falls in the course of 1 hr from an initial value greater than 2 to about 1.2. If chlorothiazide is present also, however, the ratio remains constant at 0.7. Changes in the plasma pempidine concentration in vivo probably result from the binding of pempidine to plasma protein in the presence of chlorothiazide. This has been observed in vitro by a dialysis technique.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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