Abstract
Rat stellate ganglia were isolated and maintained in a moist chamber in which they were intermittently immersed in physiological saline containing low concentrations of the compound under investigation. 5-Hydroxytryptamine (serotonin) in concentrations as low as 1.3×10-6 M reduced reversibly the threshold and increased the amplitude of responses to preganglionic stimulation. Certain antagonists of 5-hydroxytryptamine depressed reversibly the postsynaptic responses. Experiments in vivo supported this finding. It is suggested that 5-hydroxytryptamine facilitates transmission in the sympathetic ganglia of rats.
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Selected References
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