Skip to main content
NCBI home page
British Journal of Pharmacology and Chemotherapy logoLink to British Journal of Pharmacology and Chemotherapy
. 1962 Apr;18(2):247–254. doi: 10.1111/j.1476-5381.1962.tb01405.x

Relationship between anti-acetylcholine and anti-tremorine activity in anti-parkinsonian and related drugs

A Ahmed, P B Marshall
PMCID: PMC1482119  PMID: 13859738

Abstract

The anti-acetylcholine potency of a number of anti-Parkinsonism drugs and related phenothiazine compounds was determined using the isolated guinea-pig ileum. The antagonism was assessed by the difference between the pA2 and pA10 values and by log concentration-response curves for acetylcholine in presence and absence of the antagonists. All compounds except chlorpromazine showed some evidence of competitive antagonism to acetylcholine. The anti-tremor potency of the compounds was assessed from suppression of Tremorine-induced tremors in mice. There was a relation between anti-acetylcholine and anti-Tremorine potency among the anti-Parkinsonism drugs, but not among the phenothiazine compounds. Some implications of the findings are discussed in relation to the mode of action of anti-Parkinsonism drugs.

Full text

PDF
247

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AHMED A., MARSHALL P. B., SHEPHERD D. M. Pharmacology of tremor-producing amino alcohols. J Pharm Pharmacol. 1958 Nov;10(11):672–682. doi: 10.1111/j.2042-7158.1958.tb10359.x. [DOI] [PubMed] [Google Scholar]
  2. CAMBRIDGE G. W., HOLGATE J. A. Superfusion as a method for the study of drug antagonism. Br J Pharmacol Chemother. 1955 Sep;10(3):326–335. doi: 10.1111/j.1476-5381.1955.tb00878.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. EDGE N. D. The pharmacological differentiation of promethazine hydrochloride (phenergan) from iso-promethazine hydrochloride. Arch Int Pharmacodyn Ther. 1953 Sep 15;95(3-4):428–436. [PubMed] [Google Scholar]
  4. GARVEN J. D. Pharmacological blocking actions of atropine and certain atropine-like compounds. J Pharm Pharmacol. 1956 Apr;8(4):256–263. doi: 10.1111/j.2042-7158.1956.tb12155.x. [DOI] [PubMed] [Google Scholar]
  5. JENKNER F. L., WARD A., Jr Bulbar reticular formation and tremor. AMA Arch Neurol Psychiatry. 1953 Oct;70(4):489–502. [PubMed] [Google Scholar]
  6. MARSHALL P. B. Antagonism of acetylcholine by (+)- and (-)-hyoscyamine. Br J Pharmacol Chemother. 1955 Sep;10(3):354–355. doi: 10.1111/j.1476-5381.1955.tb00883.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MARSHALL P. B. Some chemical and physical properties associated with histamine antagonism. Br J Pharmacol Chemother. 1955 Sep;10(3):270–278. doi: 10.1111/j.1476-5381.1955.tb00870.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. RYALL R. W. Some actions of chlorpromazine. Br J Pharmacol Chemother. 1956 Sep;11(3):339–345. doi: 10.1111/j.1476-5381.1956.tb01078.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. TIMMS A. R. The mode of action of some non-specific acetylcholine antagonists. Br J Pharmacol Chemother. 1956 Sep;11(3):273–281. doi: 10.1111/j.1476-5381.1956.tb01066.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. ZETLER G. Der Harmin-Tremor und seine Antagonisten. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1957;231(1):34–54. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology and Chemotherapy are provided here courtesy of The British Pharmacological Society

RESOURCES