Abstract
5-Hydroxytryptamine was not detected in animal cerebrospinal fluid after amine oxidase inhibitors, reserpine, or both. Both human and animal cerebrospinal fluid can produce a stimulating effect on the clam heart which is not due to 5-hydroxytryptamine. Cerebrospinal fluid also has the property of increasing the sensitivity of the clam heart to 5-hydroxytryptamine.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BHATTACHARYA B. K., FELDBERG W., VOGT W. Some properties of the substance in human cerebrospinal fiuid sensitizing the frog rectus muscle to acetylcholine. J Physiol. 1957 Aug 6;137(3):460–472. doi: 10.1113/jphysiol.1957.sp005827. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BOGDANSKI D. F., WEISSBACH H., UDENFRIEND Pharmacological studies with the serotonin precursor, 5-hydroxytryptophan. J Pharmacol Exp Ther. 1958 Feb;122(2):182–194. [PubMed] [Google Scholar]
- LUDUENA F. P., BROWN T. G., Jr Mytolon and related compounds as antagonists of acetylcholine on the heart of Venus mercenaria. J Pharmacol Exp Ther. 1952 Jun;105(2):232–239. [PubMed] [Google Scholar]
- SCHAIN R. J. Neurohumors and other pharmacologically active substances in cerebrospinal fluid: a review of the literature. Yale J Biol Med. 1960 Aug;33:15–36. [PMC free article] [PubMed] [Google Scholar]
- STEWART W. C. Accumulation of acetylcholine in brain and blood of animals poisoned with cholinesterase inhibitors. Br J Pharmacol Chemother. 1952 Jun;7(2):270–276. doi: 10.1111/j.1476-5381.1952.tb01322.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TURNER W. J., MAUSS E. A. Serotonin (5-hydroxytryptamine) and acetylcholine in human ventricular and spinal fluids. AMA Arch Gen Psychiatry. 1959 Dec;1:646–650. doi: 10.1001/archpsyc.1959.03590060108012. [DOI] [PubMed] [Google Scholar]
- WELSH J. H. Serotonin as a possible neurohumoral agent; evidence obtained in lower animals. Ann N Y Acad Sci. 1957 Mar 14;66(3):618–630. doi: 10.1111/j.1749-6632.1957.tb40752.x. [DOI] [PubMed] [Google Scholar]
- WOOLLEY D. W., CAMPBELL N. K. Exploration of the central nervous system serotonin in humans. Ann N Y Acad Sci. 1962 Jan 13;96:108–117. doi: 10.1111/j.1749-6632.1962.tb50106.x. [DOI] [PubMed] [Google Scholar]