Abstract
Kinins, like bradykinin, are rapidly inactivated in blood and interstitial fluid by an enzyme called kininase. The action of this enzyme was found to be inhibited at slightly acid pH although the formation of kinins proceeded normally. Thus a slightly acid pH which is known to occur in inflamed and damaged tissue is a suitable environment to allow accumulation of kinins which are thought to be the mediators of the inflammatory response.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BARCROFT H., COBBOLD A. F. The action of adrenaline on muscle blood flow and blood lactate in man. J Physiol. 1956 May 28;132(2):372–378. doi: 10.1113/jphysiol.1956.sp005530. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ELLIOTT D. F., HORTON E. W., LEWIS G. P. Actions of pure bradykinin. J Physiol. 1960 Oct;153:473–480. doi: 10.1113/jphysiol.1960.sp006548. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HORTON E. W. The estimation of urinary kallkrein. J Physiol. 1959 Oct;148:267–282. doi: 10.1113/jphysiol.1959.sp006287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LEWIS G. P. Formation of plasma kinins by plasmin. J Physiol. 1958 Feb 17;140(2):285–300. doi: 10.1113/jphysiol.1958.sp005934. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WERLE E., KEHL R., KOEBKE K. Uber Bradykinin, Kallidin und Hypertensin. Biochem Z. 1950;320(4):372–383. [PubMed] [Google Scholar]