Abstract
The importance of tissue storage as a method of inactivation of circulating catechol amines has been assessed by measuring the amount of unchanged hormone remaining in the mouse 30 min after the injection of various doses of [3H]-adrenaline or [3H]-noradrenaline. The results show that this method of inactivation is quantitatively more important for noradrenaline than for adrenaline at all dose levels studied, and that for both hormones storage is relatively more important at physiological dose levels (3 to 30 μg/kg) than at higher dose levels (150 to 300 μg/kg). The results obtained after the simultaneous injection of various doses of [3H]-adrenaline and [14C]-noradrenaline show that under certain conditions the two hormones compete for entry into the tissue storage sites. The possible nature of the mechanisms by which circulating catechol amines enter the tissue stores is discussed in the light of previous findings on the uptake of catechol amines by tissues in vitro.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AXELROD J., TOMCHICK R. Increased rate of metabolism of epinephrine and norepinephrine by sympathomimetic amines. J Pharmacol Exp Ther. 1960 Dec;130:367–369. [PubMed] [Google Scholar]
- AXELROD J., WEIL-MALHERBE H., TOMCHICK R. The physiological disposition of H3-epinephrine and its metabolite metanephrine. J Pharmacol Exp Ther. 1959 Dec;127:251–256. [PubMed] [Google Scholar]
- BURN J. H., RAND M. J. The action of sympathomimetic amines in animals treated with reserpine. J Physiol. 1958 Dec 4;144(2):314–336. doi: 10.1113/jphysiol.1958.sp006104. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DENGLER H. J., SPIEGEL H. E., TITUS E. O. Uptake of tritium-labeled norepinephrine in brain and other tissues of cat in vitro. Science. 1961 Apr 7;133(3458):1072–1073. doi: 10.1126/science.133.3458.1072. [DOI] [PubMed] [Google Scholar]
- HERTTING G., AXELROD J. Fate of tritiated noradrenaline at the sympathetic nerve-endings. Nature. 1961 Oct 14;192:172–173. doi: 10.1038/192172a0. [DOI] [PubMed] [Google Scholar]
- HERTTING G., HESS S. M. The site of binding of injected H-norepinephrine. Experientia. 1962 May 15;18:214–215. doi: 10.1007/BF02148306. [DOI] [PubMed] [Google Scholar]
- HUGHES F. B., BRODIE B. B. The mechanism of serotonin and catecholamine uptake by platelets. J Pharmacol Exp Ther. 1959 Oct;127:96–102. [PubMed] [Google Scholar]
- KOPIN I. J., AXELROD J., GORDON E. The metabolic fate of H3-epinephrine and C14-metanephrine in the rat. J Biol Chem. 1961 Jul;236:2109–2113. [PubMed] [Google Scholar]
- PENNEFATHER J. N., RAND M. J. Increase in noradrenaline content of tissues after infusion of noradrenaline, dopamine and L-DOPA. J Physiol. 1960 Dec;154:277–287. doi: 10.1113/jphysiol.1960.sp006579. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PISANO J. J. A simple analysis for normetanephrine and metanephrine in urine. Clin Chim Acta. 1960 May;5:406–414. doi: 10.1016/0009-8981(60)90146-7. [DOI] [PubMed] [Google Scholar]
- POTTER L. T., AXELROD J. Intracellular localization of catecholamines in tissues of the rat. Nature. 1962 May 12;194:581–582. doi: 10.1038/194581a0. [DOI] [PubMed] [Google Scholar]
- ROSELL S., SEDVALL G. Restoration of vasoconstrictor effects in reserpinized cats. Acta Physiol Scand. 1961 Oct;53:174–184. doi: 10.1111/j.1748-1716.1961.tb02275.x. [DOI] [PubMed] [Google Scholar]
- STROMBLAD B. C., NICKERSON M. Accumulation of epinephrine and norepinephrine by some rat tissues. J Pharmacol Exp Ther. 1961 Nov;134:154–159. [PubMed] [Google Scholar]
- WHITBY L. G., AXELROD J., WEIL-MALHERBE H. The fate of H3-norepinephrine in animals. J Pharmacol Exp Ther. 1961 May;132:193–201. [PubMed] [Google Scholar]
- WILSON C. W., MURRAY A. W., TITUS E. The effects of reserpine on uptake of epinephrine in brain and certain areas outside the blood-brain barrier. J Pharmacol Exp Ther. 1962 Jan;135:11–16. [PubMed] [Google Scholar]