Skip to main content
NCBI home page
British Journal of Pharmacology and Chemotherapy logoLink to British Journal of Pharmacology and Chemotherapy
. 1962 Dec;19(3):365–374. doi: 10.1111/j.1476-5381.1962.tb01441.x

Effect of antisympathomimetic drugs on the plasma concentrations of catechol amines

G L Willey
PMCID: PMC1482210  PMID: 14000807

Abstract

Intravenous injection of phenoxybenzamine, choline 2,6-xylyl ether bromide (xylocholine, TM 10), piperoxane or dihydroergotamine increases the vasopressor activity of blood plasma, collected from cats under chloralose anaesthesia. The increased vasopressor activity that follows the administration of piperoxane is due to an increase of adrenaline and noradrenaline in the plasma. Cross-circulation experiments show that catechol amines are liberated from the spleen by piperoxane.

Full text

PDF
365

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENFEY B. G., LEDOUX G., MELVILLE K. I. Increased urinary excretion of adrenaline and noradrenaline after phenoxybenzamine. Br J Pharmacol Chemother. 1959 Mar;14(1):142–148. doi: 10.1111/j.1476-5381.1959.tb00941.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BENFEY B. G., LEDOUX G., SEGAL M. The action of antisympathomimetic drugs on the urinary excretion of adrenaline and noradrenaline. Br J Pharmacol Chemother. 1959 Sep;14:380–384. doi: 10.1111/j.1476-5381.1959.tb00262.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BROWN G. L., GILLESPIE J. S. The output of sympathetic transmitter from the spleen of the cat. J Physiol. 1957 Aug 29;138(1):81–102. doi: 10.1113/jphysiol.1957.sp005839. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BURGER M., GIGER K., KAGI J., LANGEMANN H. Anderung der Adrenalin- und Noradrenalinkonzentration im menschlichen Blutplasma unter Phentolamin (Regitin). Helv Physiol Pharmacol Acta. 1957;15(1):8–13. [PubMed] [Google Scholar]
  5. CORNE S. J., GRAHAM J. D. The effect of inhibition of amine oxidase in vivo on administered adrenaline, noradrenaline, tyramine and serotonin. J Physiol. 1957 Feb 15;135(2):339–349. doi: 10.1113/jphysiol.1957.sp005714. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. CRAWFORD T. B. B., OUTSCHOORN A. S. The quantitative separation of adrenaline and noradrenaline in biological fluids and tissue extracts. Br J Pharmacol Chemother. 1951 Mar;6(1):8–19. doi: 10.1111/j.1476-5381.1951.tb00614.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. EDGE N. D., MASON D. F., WYLLIE J. H. Some actions of substituted choline phenyl ethers, particularly of choline 2:6-xylyl ether. Br J Pharmacol Chemother. 1957 Sep;12(3):312–319. doi: 10.1111/j.1476-5381.1957.tb00140.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. GADDUM J. H., LEMBECK F. The assay of substances from the adrenal medulla. Br J Pharmacol Chemother. 1949 Dec;4(4):401–408. doi: 10.1111/j.1476-5381.1949.tb00566.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. GROSS F., TRIPOD J., MEIER Regitin (Präparat C 7337), ein neues Imidazolinderivat mit spezifischer sympathikolytischer Wirkung. Schweiz Med Wochenschr. 1951 Apr 14;81(15):352–357. [PubMed] [Google Scholar]
  10. HEY P., WILLEY G. L. Choline 2 : 6-xylyl ether bromide; an active quaternary local anaesthetic. Br J Pharmacol Chemother. 1954 Dec;9(4):471–475. doi: 10.1111/j.1476-5381.1954.tb00863.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MILLAR R. A., KEENER E. B., BENFEY B. G. Plasma adrenaline and noradrenaline after phenoxybenzamine administration, and during haemorrhagic hypotension, in normal and adrenalectomized dogs. Br J Pharmacol Chemother. 1959 Mar;14(1):9–13. doi: 10.1111/j.1476-5381.1959.tb00921.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SCHAPIRO S. Effect of a catechol amine blocking agent (dibenzyline) on organ content and urine excretion of noradrenaline and adrenaline. Acta Physiol Scand. 1958 Jun 2;42(3-4):371–375. doi: 10.1111/j.1748-1716.1958.tb01571.x. [DOI] [PubMed] [Google Scholar]
  13. TRENDELENBURG U. The supersensitivity caused by cocaine. J Pharmacol Exp Ther. 1959 Jan;125(1):55–65. [PubMed] [Google Scholar]
  14. VOGT M. The secretion of the denervated adrenal medulla of the cat. Br J Pharmacol Chemother. 1952 Jun;7(2):325–330. doi: 10.1111/j.1476-5381.1952.tb01329.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. WILLEY G. L. Some pharmacological actions of choline 2:6-xylyl ether bromide. Br J Pharmacol Chemother. 1957 Mar;12(1):128–132. doi: 10.1111/j.1476-5381.1957.tb01374.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology and Chemotherapy are provided here courtesy of The British Pharmacological Society

RESOURCES