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. 1962 Dec;19(3):375–384. doi: 10.1111/j.1476-5381.1962.tb01442.x

Depression of muscle spindle activity—a new type of pharmacological action?

H J Bein, H-U Fehr
PMCID: PMC1482214  PMID: 13970329

Abstract

The effect of 2,4-di(diethylamino)-6-(2-phenylacetylhydrazino)-1,3,5-triazine (Ciba 28882-Ba) injected intravenously on the activity of de-efferented muscle spindles of the tibialis anterior and extensor digitorum longus muscles of anaesthetized cats, and on γ-motoneurones of decerebrate cats, was investigated. The drug depressed both the static activity of muscle spindles and the spontaneous activity of γ-motoneurones. In contrast, the response of muscle spindles to rapid stretch was not affected. The effect of 28882-Ba on the activity of the muscle spindles resembled that of progressive unloading or shortening of the muscle. 28882-Ba antagonized excitation of the muscle spindle by suxamethonium. The effect of 28882-Ba on the response of the γ-motoneurones to various driving stimuli was not predictable.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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