Abstract
The actions of bradykinin, angiotensin, oxytocin, vasopressin and substance P have been examined both on isolated smooth muscle preparations and in vivo. It was found that the isolated rat uterus and guinea-pig ileum can be used to distinguish between oxytocin and bradykinin and that the isolated rat colon and hen rectal caecum are almost specific test preparations for substance P. All the peptides were active on peripheral blood vessels, bradykinin, substance P and oxytocin causing vasodilatation and vasopressin and angiotensin vasoconstriction; bradykinin, substance P and angiotensin also caused an increase in capillary permeability in guinea-pigs. Only bradykinin and substance P were active in low concentrations in producing pain when applied to an exposed blister base. These two peptides were also active in causing bronchoconstriction. Oxytocin and vasopressin were the only peptides having milk-ejecting or antidiuretic activity which could be dissociated from cardiovascular effects. The spectrum of activity displayed by these peptides is in agreement with those functions which have been established for vasopressin and oxytocin and with those suggested, but not yet fully accepted, for bradykinin and angiotensin. It also indicates a possible function for substance P based on its vascular and permeability effects.
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- AMES R. G., VAN DYKE H. B. Antidiuretic hormone in the serum or plasma of rats. Endocrinology. 1952 Mar;50(3):350–360. doi: 10.1210/endo-50-3-350. [DOI] [PubMed] [Google Scholar]
- ARMSTRONG D., DRY R. M. L., KEELE C. A., MARKHAM J. W. Observations on chemical excitants of cutaneous pain in man. J Physiol. 1953 May 28;120(3):326–351. doi: 10.1113/jphysiol.1953.sp004898. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BISSET G. W. Effect of tyrosinase preparations on oxytocin, vasopressin and bradykinin. Br J Pharmacol Chemother. 1962 Apr;18:405–420. doi: 10.1111/j.1476-5381.1962.tb01420.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BISSET G. W., LEE J. Oxytocic and antidiuretic activity in blood from the conscious subject. Lancet. 1957 Oct 19;273(6999):770–772. doi: 10.1016/s0140-6736(57)90876-0. [DOI] [PubMed] [Google Scholar]
- BISSET G. W., WALKER J. M. Assay of oxytocin in blood. J Physiol. 1954 Dec 10;126(3):588–595. doi: 10.1113/jphysiol.1954.sp005228. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COLLIER H. O., HOLGATE J. A., SCHACHTER M., SHORLEY P. G. The bronchoconstrictor action of bradykinin in the guinea-pig. Br J Pharmacol Chemother. 1960 Jun;15:290–297. doi: 10.1111/j.1476-5381.1960.tb01247.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DETTELBACH H. R. A method for assaying small amounts of antidiuretic substances with notes on some properties of vasopressin. Am J Physiol. 1958 Feb;192(2):379–386. doi: 10.1152/ajplegacy.1958.192.2.379. [DOI] [PubMed] [Google Scholar]
- DICKER S. E. A method for the assay of very small amounts of antidiuretic activity with a note on the antidiuretic titre of rat's blood. J Physiol. 1953 Oct;122(1):149–157. doi: 10.1113/jphysiol.1953.sp004986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FELDBERG W., MONGAR J. L. Comparison of histamine release by compound 48/80 and octylamine in perfused tissues. Br J Pharmacol Chemother. 1954 Jun;9(2):197–201. doi: 10.1111/j.1476-5381.1954.tb00841.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GADDUM J. H., SZERB J. C. Assay of substance P on goldfish intestine in a microbath. Br J Pharmacol Chemother. 1961 Dec;17:451–463. doi: 10.1111/j.1476-5381.1961.tb01132.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HAWKER R. W., ROBERTSON P. A. Some properties of an oxytocic substance found in blood extracts. Endocrinology. 1958 Aug;63(2):242–249. doi: 10.1210/endo-63-2-242. [DOI] [PubMed] [Google Scholar]
- HILTON S. M., LEWIS G. P. Functional vasodilatation in the submandibular salivary gland. Br Med Bull. 1957 Sep;13(3):189–196. doi: 10.1093/oxfordjournals.bmb.a069612. [DOI] [PubMed] [Google Scholar]
- LEWIS G. P. Active polypeptides derived from plasma proteins. Physiol Rev. 1960 Oct;40:647–676. doi: 10.1152/physrev.1960.40.4.647. [DOI] [PubMed] [Google Scholar]
- LEWIS G. P. Plasma-kinin-forming enzymes in body fluids and tissues. J Physiol. 1959 Oct;147:458–468. doi: 10.1113/jphysiol.1959.sp006256. [DOI] [PMC free article] [PubMed] [Google Scholar]