Abstract
This paper describes two patients with endometriosis in whom treatment with danazol resulted in a concomitant remission of asthma. Neither patient reported an association of clinical symptoms with phases of their menstrual cycle. Whether the remission was fortuitous or related to suppression of the activity of the endometriotic tissue or to the ability of danazol to increase the serum levels of two protease inhibitors that are deficient in patients with asthma remains to be determined.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Badawy S. Z., Marshall L., Gabal A. A., Nusbaum M. L. The concentration of 13,14-dihydro-15-keto prostaglandin F2 alpha and prostaglandin E2 in peritoneal fluid of infertile patients with and without endometriosis. Fertil Steril. 1982 Aug;38(2):166–170. doi: 10.1016/s0015-0282(16)46453-8. [DOI] [PubMed] [Google Scholar]
- Dmowski W. P. Endocrine properties and clinical application of danazol. Fertil Steril. 1979 Mar;31(3):237–251. doi: 10.1016/s0015-0282(16)43869-0. [DOI] [PubMed] [Google Scholar]
- Gadek J., Fulmer J., Frank M., Petty T., Crystal R. Danazol-induced elevation of serum alpha 1-antitrypsin in individuals with severe deficiency of this antiprotease. Chest. 1980 Feb;77(2 Suppl):279–279. doi: 10.1378/chest.77.2_supplement.279. [DOI] [PubMed] [Google Scholar]
- Häfner G. E., Wüthrich B., Grob P. J., Arrenbrecht S. Circulating immune complexes, complement factors C3, C4, C1-inhibitor, alpha-1-antitrypsin and immunoglobulins in asthmatic patients. Respiration. 1981;41(4):248–257. doi: 10.1159/000194389. [DOI] [PubMed] [Google Scholar]
- Mathé A. A., Hedqvist P., Holmgren A., Svanborg N. Bronchial hyperreactivity to prostaglandin F 2 and histamine in patients with asthma. Br Med J. 1973 Jan 27;1(5847):193–196. doi: 10.1136/bmj.1.5847.193. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moon Y. S., Leung P. C., Yuen B. H., Gomel V. Prostaglandin F in human endometriotic tissue. Am J Obstet Gynecol. 1981 Oct 1;141(3):344–345. doi: 10.1016/s0002-9378(16)32641-2. [DOI] [PubMed] [Google Scholar]
- Rock J. A., Dubin N. H., Ghodgaonkar R. B., Bergquist C. A., Erozan Y. S., Kimball A. W., Jr Cul-de-sac fluid in women with endometriosis: fluid volume and prostanoid concentration during the proliferative phase of the cycle--days 8 to 12. Fertil Steril. 1982 Jun;37(6):747–750. doi: 10.1016/s0015-0282(16)46332-6. [DOI] [PubMed] [Google Scholar]