Skip to main content
NCBI home page
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1984 Sep 15;131(6):595–600.

Adult T-cell leukemia-lymphoma with mediastinal involvement and an asymptomatic chronic phase.

D Amato, B J Fernandes, M Klein
PMCID: PMC1483631  PMID: 6089987

Abstract

A black, West Indian woman with adult T-cell leukemia-lymphoma (ATLL), hypercalcemia, peripheral and retroperitoneal lymphadenopathy, and serum antibodies to human T-lymphotropic virus (HTLV) was found to have massive mediastinal adenopathy, a feature not previously reported in patients with ATLL. In addition, she had had asymptomatic leukocytosis with marked lymphocytosis for at least 6 years before presenting with full-blown ATLL. These findings broaden the clinical picture of ATLL. Cell surface-marker studies and close follow-up are recommended for patients with apparent chronic lymphocytic leukemia, especially if they have pleomorphic lymphocytosis, are younger than usual or are from the Caribbean or Japan.

Full text

PDF
595

Images in this article

596Fig. 1
on p.596
596Fig. 2
on p.596
596Fig. 3
on p.596

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blattner W. A., Gibbs W. N., Saxinger C., Robert-Guroff M., Clark J., Lofters W., Hanchard B., Campbell M., Gallo R. C. Human T-cell leukaemia/lymphoma virus-associated lymphoreticular neoplasia in Jamaica. Lancet. 1983 Jul 9;2(8341):61–64. doi: 10.1016/s0140-6736(83)90056-9. [DOI] [PubMed] [Google Scholar]
  2. Bunn P. A., Jr, Schechter G. P., Jaffe E., Blayney D., Young R. C., Matthews M. J., Blattner W., Broder S., Robert-Guroff M., Gallo R. C. Clinical course of retrovirus-associated adult T-cell lymphoma in the United States. N Engl J Med. 1983 Aug 4;309(5):257–264. doi: 10.1056/NEJM198308043090501. [DOI] [PubMed] [Google Scholar]
  3. Catovsky D., Greaves M. F., Rose M., Galton D. A., Goolden A. W., McCluskey D. R., White J. M., Lampert I., Bourikas G., Ireland R. Adult T-cell lymphoma-leukaemia in Blacks from the West Indies. Lancet. 1982 Mar 20;1(8273):639–643. doi: 10.1016/s0140-6736(82)92200-0. [DOI] [PubMed] [Google Scholar]
  4. Catovsky D., Linch D. C., Beverley P. C. T cell disorders in haematological diseases. Clin Haematol. 1982 Oct;11(3):661–695. [PubMed] [Google Scholar]
  5. Gallo R. C., Sarin P. S., Gelmann E. P., Robert-Guroff M., Richardson E., Kalyanaraman V. S., Mann D., Sidhu G. D., Stahl R. E., Zolla-Pazner S. Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS). Science. 1983 May 20;220(4599):865–867. doi: 10.1126/science.6601823. [DOI] [PubMed] [Google Scholar]
  6. Greaves M. F., Rao J., Hariri G., Verbi W., Catovsky D., Kung P., Goldstein G. Phenotypic heterogeneity and cellular origins of T cell malignancies. Leuk Res. 1981;5(4-5):281–299. doi: 10.1016/0145-2126(81)90001-1. [DOI] [PubMed] [Google Scholar]
  7. Kalyanaraman V. S., Sarngadharan M. G., Bunn P. A., Minna J. D., Gallo R. C. Antibodies in human sera reactive against an internal structural protein of human T-cell lymphoma virus. Nature. 1981 Nov 19;294(5838):271–273. doi: 10.1038/294271a0. [DOI] [PubMed] [Google Scholar]
  8. Kinoshita K., Amagasaki T., Yamada Y., Ikeda S., Momita S., Toriya K., Kamihira S., Ichimaru M. Adult T-cell leukemia-lymphoma-related diseases in the Nagasaki District. Jpn J Clin Oncol. 1983;13 (Suppl 2):215–230. [PubMed] [Google Scholar]
  9. Kinoshita K., Kamihira S., Ikeda S., Yamada Y., Muta T., Kitamura T., Ichimaru M., Matsuo T. Clinical, hematologic, and pathologic features of leukemic T-cell lymphoma. Cancer. 1982 Oct 15;50(8):1554–1562. doi: 10.1002/1097-0142(19821015)50:8<1554::aid-cncr2820500815>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  10. McKelvey E. M., Gottlieb J. A., Wilson H. E., Haut A., Talley R. W., Stephens R., Lane M., Gamble J. F., Jones S. E., Grozea P. N. Hydroxyldaunomycin (Adriamycin) combination chemotherapy in malignant lymphoma. Cancer. 1976 Oct;38(4):1484–1493. doi: 10.1002/1097-0142(197610)38:4<1484::aid-cncr2820380407>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  11. Popovic M., Sarngadharan M. G., Read E., Gallo R. C. Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science. 1984 May 4;224(4648):497–500. doi: 10.1126/science.6200935. [DOI] [PubMed] [Google Scholar]
  12. Posner L. E., Robert-Guroff M., Kalyanaraman V. S., Poiesz B. J., Ruscetti F. W., Fossieck B., Bunn P. A., Jr, Minna J. D., Gallo R. C. Natural antibodies to the human T cell lymphoma virus in patients with cutaneous T cell lymphomas. J Exp Med. 1981 Aug 1;154(2):333–346. doi: 10.1084/jem.154.2.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Shimoyama M., Minato K., Tobinai K., Nagai M., Setoya T., Takenaka T., Ishihara K., Watanabe S., Hoshino H., Miwa M. Atypical adult T-cell leukemia-lymphoma: diverse clinical manifestations of adult T-cell leukemia-lymphoma. Jpn J Clin Oncol. 1983;13 (Suppl 2):165–187. [PubMed] [Google Scholar]
  14. Uchiyama T., Yodoi J., Sagawa K., Takatsuki K., Uchino H. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood. 1977 Sep;50(3):481–492. [PubMed] [Google Scholar]
  15. Yamaguchi K., Nishimura H., Kohrogi H., Jono M., Miyamoto Y., Takatsuki K. A proposal for smoldering adult T-cell leukemia: a clinicopathologic study of five cases. Blood. 1983 Oct;62(4):758–766. [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES