Abstract
A simple method of simulating cell kinetics experiments, suitable for use on small generally available computers and capable of any degree of accuracy without increase of store required, is described. No assumption is necessary as to cycle-time distribution; the computer program, after being adjusted to generate percentage labeled mitosis curves, will then, on being supplied with different data, generate the cycle-time distribution curve.
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Selected References
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- Barrett J. C. A mathematical model of the mitotic cycle and its application to the interpretation of percentage labeled mitoses data. J Natl Cancer Inst. 1966 Oct;37(4):443–450. [PubMed] [Google Scholar]
- Bronk B. V., Dienes G. J., Paskin A. The stochastic theory of cell proliferation. Biophys J. 1968 Nov;8(11):1353–1398. doi: 10.1016/S0006-3495(68)86561-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bronk B. V. On radioactive labeling of proliferating cells: the graph of labeled mitosis. J Theor Biol. 1969 Mar;22(3):468–492. doi: 10.1016/0022-5193(69)90016-2. [DOI] [PubMed] [Google Scholar]
- Denekamp J. The cellular proliferation kinetics of animal tumors. Cancer Res. 1970 Feb;30(2):393–400. [PubMed] [Google Scholar]
- Hirsch H. R., Engelberg J. Decay of cell synchronization: solutions of the cell-growth equation. Bull Math Biophys. 1966 Sep;28(3):391–409. doi: 10.1007/BF02476821. [DOI] [PubMed] [Google Scholar]
- Steel G. G., Adams K., Barrett J. C. Analysis of the cell population kinetics of transplanted tumours of widely-differing growth rate. Br J Cancer. 1966 Dec;20(4):784–800. doi: 10.1038/bjc.1966.90. [DOI] [PMC free article] [PubMed] [Google Scholar]