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. 1973 Oct;13(10):1071–1089. doi: 10.1016/S0006-3495(73)86046-1

Propagation Speed in Myelinated Nerve

II. Theoretical Dependence on External Na+ and on Temperature

W L Hardy
PMCID: PMC1484343  PMID: 4542941

Abstract

The Hodgkin-Huxley (H.H.) equations modified by Dodge for Rana pipiens myelinated nerve have been solved to determine how well the theory predicts the effects of changes of temperature and [Na+]0 on propagation. Conduction speed θ was found to have an approximately exponential dependence on temperature as was found experimentally, but the theoretical temperature coefficient (Q10) was low; 1.5 compared with the experimental finding of 2.95. θ was found to be a linear function of log ([Na+]0) in contrast to the experimental finding of a square root dependence on [Na+]0. θ is 50% greater at one-fourth normal [Na+]0 than the theory predicts. The difference between the theoretical θ([Na+]0) and the experimental θ([Na+]0) is probably due to an imprecisely known variation of parameters and not to a fundamental inadequacy of the theory.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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