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. 1996 Jun 1;154(11):1631–1644.

Periodic health examination, 1996 update: 2. Screening for chlamydial infections. Canadian Task Force on the Periodic Health Examination.

H D Davies 1, E E Wang 1
PMCID: PMC1487928  PMID: 8646651

Abstract

OBJECTIVE: To update the 1984 recommendations of the Canadian Task Force on the Periodic Health Examination on the routine screening of asymptomatic patients for infection with Chlamydia trachomatis. OPTIONS: Screening, with the use of culture or nonculture tests, of the general population, of certain high-risk groups or of all pregnant women; or no routine screening. OUTCOMES: Rates of asymptomatic and symptomatic chlamydial infection, perinatal complications, longterm complications of infection (i.e., pelvic inflammatory disease, infertility and ectopic pregnancy), coinfection with other sexually transmitted diseases, disease spread, hospital care, complications of therapy and costs of infection and of screening. EVIDENCE: Search of MEDLINE for articles published between Jan. 1, 1983, and Dec. 31, 1995, with the use of the major MeSH heading "chlamydial infections," references from recent review articles and recommendation by other organizations. VALUES: The evidence-based methods of the Canadian Task Force on the Periodic Health Examination were used. Advice from reviewers and experts and recommendations of other organizations were taken into consideration. Prevention of symptomatic disease and decreased overall costs were given high values. BENEFITS, HARMS AND COSTS: The greatest potential benefits of screening asymptomatic patients for chlamydial infections are the prevention of complications, especially infertility and perinatal complications, and the prevention of disease spread. There is no evidence that screening of the general population for chlamydial infections leads to a reduction in complications, and screening may increase costs. However, there is evidence that annual screening of selected high-risk groups and of pregnant women during the first trimester is beneficial in preventing symptoms and reducing the overall cost resulting from infection. RECOMMENDATIONS: There is fair evidence to support screening and treatment of pregnant women during the first trimester (grade B recommendation) as well as annual screening and treatment of high-risk groups (sexually active women less than 25 years of age, men or women with new or multiple sexual partners during the preceding year, women who use nonbarrier contraceptive methods and women who have symptoms of chlamydial infection: cervical friability, mucopurulent cervical discharge or intermenstrual bleeding; grade B recommendation). There is fair evidence to exclude routine screening of the general population (grade D recommendation). VALIDATION: These recommendations are similar to those of the US Preventive Services Task Force and the US Centers for Disease Control and Prevention, Atlanta. SPONSOR: These guidelines were developed and endorsed by the Canadian Task Force on the Periodic Health Examination, which is funded by Health Canada and the National Health Canada and the National Health Research and Development Program. The principal author (H.D.D.) was supported in part by the Ontario Ministry of Health and the Canadian Infectious Diseases Society Lilly Fellowship.

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Selected References

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  1. Alger L. S., Lovchik J. C. Comparative efficacy of clindamycin versus erythromycin in eradication of antenatal Chlamydia trachomatis. Am J Obstet Gynecol. 1991 Aug;165(2):375–381. doi: 10.1016/0002-9378(91)90097-b. [DOI] [PubMed] [Google Scholar]
  2. Amortegul A. J., Meyer M. P., Gnatuk C. L. Prevalence of Chlamydia trachomatis and other micro-organisms in women seeking abortions in Pittsburgh, Pennsylvania, United States of America. Genitourin Med. 1986 Apr;62(2):88–92. doi: 10.1136/sti.62.2.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bagshaw S. N., Edwards D. Risk factors for Chlamydia trachomatis infection of the cervix: a prospective study of 2000 patients at a family planning clinic. N Z Med J. 1987 Jul 8;100(827):401–403. [PubMed] [Google Scholar]
  4. Bass C. A., Jungkind D. L., Silverman N. S., Bondi J. M. Clinical evaluation of a new polymerase chain reaction assay for detection of Chlamydia trachomatis in endocervical specimens. J Clin Microbiol. 1993 Oct;31(10):2648–2653. doi: 10.1128/jcm.31.10.2648-2653.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Batteiger B. E., Jones R. B., White A. Efficacy and safety of ofloxacin in the treatment of nongonococcal sexually transmitted disease. Am J Med. 1989 Dec 29;87(6C):75S–77S. [PubMed] [Google Scholar]
  6. Bauwens J. E., Clark A. M., Loeffelholz M. J., Herman S. A., Stamm W. E. Diagnosis of Chlamydia trachomatis urethritis in men by polymerase chain reaction assay of first-catch urine. J Clin Microbiol. 1993 Nov;31(11):3013–3016. doi: 10.1128/jcm.31.11.3013-3016.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bauwens J. E., Clark A. M., Stamm W. E. Diagnosis of Chlamydia trachomatis endocervical infections by a commercial polymerase chain reaction assay. J Clin Microbiol. 1993 Nov;31(11):3023–3027. doi: 10.1128/jcm.31.11.3023-3027.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Begley C. E., McGill L., Smith P. B. The incremental cost of screening, diagnosis, and treatment of gonorrhea and chlamydia in a family planning clinic. Sex Transm Dis. 1989 Apr-Jun;16(2):63–67. doi: 10.1097/00007435-198904000-00004. [DOI] [PubMed] [Google Scholar]
  9. Bianchi A., Scieux C., Brunat N., Vexiau D., Kermanach M., Pezin P., Janier M., Morel P., Lagrange P. H. An evaluation of the polymerase chain reaction amplicor Chlamydia trachomatis in male urine and female urogenital specimens. Sex Transm Dis. 1994 Jul-Aug;21(4):196–200. doi: 10.1097/00007435-199407000-00003. [DOI] [PubMed] [Google Scholar]
  10. Bischoff W. Ofloxacin: therapeutic results in Chlamydia trachomatis urethritis. Infection. 1986;14 (Suppl 4):S316–S317. doi: 10.1007/BF01661306. [DOI] [PubMed] [Google Scholar]
  11. Black-Payne C., Ahrabi M. M., Bocchini J. A., Jr, Ridenour C. R., Brouillette R. M. Treatment of Chlamydia trachomatis identified with Chlamydiazyme during pregnancy. Impact on perinatal complications and infants. J Reprod Med. 1990 Apr;35(4):362–367. [PubMed] [Google Scholar]
  12. Black J. R., Long J. M., Zwickl B. E., Ray B. S., Verdon M. S., Wetherby S., Hook E. W., 3rd, Handsfield H. H. Multicenter randomized study of single-dose ofloxacin versus amoxicillin-probenecid for treatment of uncomplicated gonococcal infection. Antimicrob Agents Chemother. 1989 Feb;33(2):167–170. doi: 10.1128/aac.33.2.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Blackwell A. L., Thomas P. D., Wareham K., Emery S. J. Health gains from screening for infection of the lower genital tract in women attending for termination of pregnancy. Lancet. 1993 Jul 24;342(8865):206–210. doi: 10.1016/0140-6736(93)92299-9. [DOI] [PubMed] [Google Scholar]
  14. Blomer R., Bruch K., Klose U. Ofloxacin in the treatment of gonococcal and chlamydial urethritis. Clin Ther. 1988;10(3):263–265. [PubMed] [Google Scholar]
  15. Boslego J. W., Hicks C. B., Greenup R., Thomas R. J., Wiener H. A., Ciak J., Tramont E. C. A prospective randomized trial of ofloxacin vs. doxycycline in the treatment of uncomplicated male urethritis. Sex Transm Dis. 1988 Oct-Dec;15(4):186–191. doi: 10.1097/00007435-198810000-00002. [DOI] [PubMed] [Google Scholar]
  16. Bowie W. R., Borrie-Hume C. J., Manzon L. M., Fawcett A., Percival-Smith R. K., Jones H. D. Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in two different populations of women. Can Med Assoc J. 1981 Jun 1;124(11):1477–1479. [PMC free article] [PubMed] [Google Scholar]
  17. Brunham R. C., Binns B., McDowell J., Paraskevas M. Chlamydia trachomatis infection in women with ectopic pregnancy. Obstet Gynecol. 1986 May;67(5):722–726. doi: 10.1097/00006250-198605000-00022. [DOI] [PubMed] [Google Scholar]
  18. Brunham R. C., Paavonen J., Stevens C. E., Kiviat N., Kuo C. C., Critchlow C. W., Holmes K. K. Mucopurulent cervicitis--the ignored counterpart in women of urethritis in men. N Engl J Med. 1984 Jul 5;311(1):1–6. doi: 10.1056/NEJM198407053110101. [DOI] [PubMed] [Google Scholar]
  19. Buhaug H., Skjeldestad F. E., Backe B., Dalen A. Cost effectiveness of testing for chlamydial infections in asymptomatic women. Med Care. 1989 Aug;27(8):833–841. doi: 10.1097/00005650-198908000-00007. [DOI] [PubMed] [Google Scholar]
  20. Bump R. C. Chlamydia trachomatis as a cause of prepubertal vaginitis. Obstet Gynecol. 1985 Mar;65(3):384–388. [PubMed] [Google Scholar]
  21. Bygdeman S. M., Lidbrink P., Nahkiaisoja M., Parkhede U. Comparison of Pharmacia Chlamydia EIA, IDEIA and cell culture in the detection of urogenital chlamydial infection. Int J STD AIDS. 1990 May;1(3):199–204. doi: 10.1177/095646249000100310. [DOI] [PubMed] [Google Scholar]
  22. Chaim W., Sarov B., Sarov I., Piura B., Cohen A., Insler V. Serum IgG and IgA antibodies to Chlamydia in ectopic pregnancies. Contraception. 1989 Jul;40(1):59–71. doi: 10.1016/0010-7824(89)90028-0. [DOI] [PubMed] [Google Scholar]
  23. Chandeying V., Sutthijumroon S., Tungphaisal S. Evaluation of ofloxacin in the treatment of mucopurulent cervicitis: response of chlamydia-positive and chlamydia-negative forms. J Med Assoc Thai. 1989 Jun;72(6):331–337. [PubMed] [Google Scholar]
  24. Chernesky M. A., Lee H., Schachter J., Burczak J. D., Stamm W. E., McCormack W. M., Quinn T. C. Diagnosis of Chlamydia trachomatis urethral infection in symptomatic and asymptomatic men by testing first-void urine in a ligase chain reaction assay. J Infect Dis. 1994 Nov;170(5):1308–1311. doi: 10.1093/infdis/170.5.1308. [DOI] [PubMed] [Google Scholar]
  25. Chernesky M., Castriciano S., Sellors J., Stewart I., Cunningham I., Landis S., Seidelman W., Grant L., Devlin C., Mahony J. Detection of Chlamydia trachomatis antigens in urine as an alternative to swabs and cultures. J Infect Dis. 1990 Jan;161(1):124–126. doi: 10.1093/infdis/161.1.124. [DOI] [PubMed] [Google Scholar]
  26. Chiarini F., Mansi A., Tomao P., Gentile V., De Marco F., Brunori S., Wongher L., Di Silverio F. Chlamydia trachomatis genitourinary infections: laboratory diagnosis and therapeutic aspects. Evaluation of in vitro and in vivo effectiveness of azithromycin. J Chemother. 1994 Aug;6(4):238–242. doi: 10.1080/1120009x.1994.11741158. [DOI] [PubMed] [Google Scholar]
  27. Chlamydial infection in Canada. CMAJ. 1992 Sep 15;147(6):893–896. [PMC free article] [PubMed] [Google Scholar]
  28. Cleary R. E., Jones R. B. Recovery of Chlamydia trachomatis from the endometrium in infertile women with serum antichlamydial antibodies. Fertil Steril. 1985 Aug;44(2):233–235. doi: 10.1016/s0015-0282(16)48743-1. [DOI] [PubMed] [Google Scholar]
  29. Cohen I., Veille J. C., Calkins B. M. Improved pregnancy outcome following successful treatment of chlamydial infection. JAMA. 1990 Jun 20;263(23):3160–3163. [PubMed] [Google Scholar]
  30. Conway D., Glazener C. M., Caul E. O., Hodgson J., Hull M. G., Clarke S. K., Stirrat G. M. Chlamydial serology in fertile and infertile women. Lancet. 1984 Jan 28;1(8370):191–193. doi: 10.1016/s0140-6736(84)92113-5. [DOI] [PubMed] [Google Scholar]
  31. Corrado M. L. The clinical experience with ofloxacin in the treatment of sexually transmitted diseases. Am J Obstet Gynecol. 1991 May;164(5 Pt 2):1396–1399. doi: 10.1016/0002-9378(91)91480-k. [DOI] [PubMed] [Google Scholar]
  32. Coudron P. E., Fedorko D. P., Dawson M. S., Kaplowitz L. G., Brookman R. R., Dalton H. P., Davis B. A. Detection of Chlamydia trachomatis in genital specimens by the Microtrak direct specimen test. Am J Clin Pathol. 1986 Jan;85(1):89–92. doi: 10.1093/ajcp/85.1.89. [DOI] [PubMed] [Google Scholar]
  33. Crombleholme W. R., Schachter J., Grossman M., Landers D. V., Sweet R. L. Amoxicillin therapy for Chlamydia trachomatis in pregnancy. Obstet Gynecol. 1990 May;75(5):752–756. [PubMed] [Google Scholar]
  34. Csángó P. A., Gundersen T., Martinsen I. M. Effect of amoxicillin on simultaneous Chlamydia trachomatis infection in men with gonococcal urethritis: comparison of three dosage regimens. Sex Transm Dis. 1985 Apr-Jun;12(2):93–96. doi: 10.1097/00007435-198504000-00009. [DOI] [PubMed] [Google Scholar]
  35. Cumming D. C., Honoré L. H., Scott J. Z., Williams K. E. Microscopic evidence of silent inflammation in grossly normal fallopian tubes with ectopic pregnancy. Int J Fertil. 1988 Sep-Oct;33(5):324–328. [PubMed] [Google Scholar]
  36. Dylewski J., Clecner B., Dubois J., St-Pierre C., Murray G., Bouchard C., Phillips R. Comparison of spiramycin and doxycycline for treatment of Chlamydia trachomatis genital infections. Antimicrob Agents Chemother. 1993 Jun;37(6):1373–1374. doi: 10.1128/aac.37.6.1373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Embil J. A., Pereira L. H. Prevalence of Chlamydia trachomatis and genital mycoplasmas in asymptomatic women. Can Med Assoc J. 1985 Jul 1;133(1):34–35. [PMC free article] [PubMed] [Google Scholar]
  38. Estany A., Todd M., Vasquez M., McLaren R. Early detection of genital chlamydial infection in women: an economic evaluation. Sex Transm Dis. 1989 Jan-Mar;16(1):21–27. doi: 10.1097/00007435-198901000-00005. [DOI] [PubMed] [Google Scholar]
  39. Faro S., Martens M. G., Maccato M., Hammill H. A., Roberts S., Riddle G. Effectiveness of ofloxacin in the treatment of Chlamydia trachomatis and Neisseria gonorrhoeae cervical infection. Am J Obstet Gynecol. 1991 May;164(5 Pt 2):1380–1383. doi: 10.1016/0002-9378(91)91476-d. [DOI] [PubMed] [Google Scholar]
  40. Fedele L., Acaia B., Ricciardiello O., Marchini M., Benzi-Cipelli R. Recovery of Chlamydia trachomatis from the endometria of women with unexplained infertility. J Reprod Med. 1989 Jun;34(6):393–396. [PubMed] [Google Scholar]
  41. Forbes B. A., Bartholoma N., McMillan J., Roefaro M., Weiner L., Welych L. Evaluation of a monoclonal antibody test to detect chlamydia in cervical and urethral specimens. J Clin Microbiol. 1986 Jun;23(6):1136–1137. doi: 10.1128/jcm.23.6.1136-1137.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Frommell G. T., Rothenberg R., Wang S., McIntosh K. Chlamydial infection of mothers and their infants. J Pediatr. 1979 Jul;95(1):28–32. doi: 10.1016/s0022-3476(79)80077-3. [DOI] [PubMed] [Google Scholar]
  43. Fuster C. D., Neinstein L. S. Vaginal Chlamydia trachomatis prevalence in sexually abused prepurbertal girls. Pediatrics. 1987 Feb;79(2):235–238. [PubMed] [Google Scholar]
  44. Gaydos C. A., Reichart C. A., Long J. M., Welsh L. E., Neumann T. M., Hook E. W., 3rd, Quinn T. C. Evaluation of Syva enzyme immunoassay for detection of Chlamydia trachomatis in genital specimens. J Clin Microbiol. 1990 Jul;28(7):1541–1544. doi: 10.1128/jcm.28.7.1541-1544.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Genç M., Ruusuvaara L., Mårdh P. A. An economic evaluation of screening for Chlamydia trachomatis in adolescent males. JAMA. 1993 Nov 3;270(17):2057–2064. doi: 10.1001/jama.1993.03510170047029. [DOI] [PubMed] [Google Scholar]
  46. Gibson M., Gump D., Ashikaga T., Hall B. Patterns of adnexal inflammatory damage: Chlamydia, the intrauterine device, and history of pelvic inflammatory disease. Fertil Steril. 1984 Jan;41(1):47–51. doi: 10.1016/s0015-0282(16)47539-4. [DOI] [PubMed] [Google Scholar]
  47. Golden N., Hammerschlag M., Neuhoff S., Gleyzer A. Prevalence of Chlamydia trachomatis cervical infection in female adolescents. Am J Dis Child. 1984 Jun;138(6):562–564. doi: 10.1001/archpedi.1984.02140440046010. [DOI] [PubMed] [Google Scholar]
  48. Graber C. D., Williamson O., Pike J., Valicenti J. Detection of Chlamydia trachomatis infection in endocervical specimens using direct immunofluorescence. Obstet Gynecol. 1985 Nov;66(5):727–730. [PubMed] [Google Scholar]
  49. Grant J. B., Costello C. B., Sequeira P. J., Blacklock N. J. The role of Chlamydia trachomatis in epididymitis. Br J Urol. 1987 Oct;60(4):355–359. doi: 10.1111/j.1464-410x.1987.tb04985.x. [DOI] [PubMed] [Google Scholar]
  50. Gump D. W., Gibson M., Ashikaga T. Evidence of prior pelvic inflammatory disease and its relationship to Chlamydia trachomatis antibody and intrauterine contraceptive device use in infertile women. Am J Obstet Gynecol. 1983 May 15;146(2):153–159. doi: 10.1016/0002-9378(83)91044-x. [DOI] [PubMed] [Google Scholar]
  51. Hammerschlag M. R., Golden N. H., Oh M. K., Gelling M., Sturdevant M., Brown P. R., Aras Z., Neuhoff S., Dumornay W., Roblin P. M. Single dose of azithromycin for the treatment of genital chlamydial infections in adolescents. J Pediatr. 1993 Jun;122(6):961–965. doi: 10.1016/s0022-3476(09)90029-4. [DOI] [PubMed] [Google Scholar]
  52. Handsfield H. H., Jasman L. L., Roberts P. L., Hanson V. W., Kothenbeutel R. L., Stamm W. E. Criteria for selective screening for Chlamydia trachomatis infection in women attending family planning clinics. JAMA. 1986 Apr 4;255(13):1730–1734. [PubMed] [Google Scholar]
  53. Harrison H. R., Boyce W. T., Haffner W. H., Crowley B., Weinstein L., Lewis M., Alexander E. R. The prevalence of genital Chlamydia trachomatis and mycoplasmal infections during pregnancy in an American Indian population. Sex Transm Dis. 1983 Oct-Dec;10(4):184–186. doi: 10.1097/00007435-198311000-00004. [DOI] [PubMed] [Google Scholar]
  54. Hartford S. L., Silva P. D., diZerega G. S., Yonekura M. L. Serologic evidence of prior chlamydial infection in patients with tubal ectopic pregnancy and contralateral tubal disease. Fertil Steril. 1987 Jan;47(1):118–121. doi: 10.1016/s0015-0282(16)49946-2. [DOI] [PubMed] [Google Scholar]
  55. Hauger S. B., Brown J., Agre F., Sahraie F., Ortiz R., Ellner P. Failure of direct fluorescent antibody staining to detect Chlamydia trachomatis from genital tract sites of prepubertal children at risk for sexual abuse. Pediatr Infect Dis J. 1988 Sep;7(9):660–662. [PubMed] [Google Scholar]
  56. Henry-Suchet J., Utzmann C., De Brux J., Ardoin P., Catalan F. Microbiologic study of chronic inflammation associated with tubal factor infertility: role of Chlamydia trachomatis. Fertil Steril. 1987 Feb;47(2):274–277. doi: 10.1016/s0015-0282(16)50005-3. [DOI] [PubMed] [Google Scholar]
  57. Hobson D., Arya O. P., Rao P. M., Lee N., Tait I. A., Bradley M. G., Mallinson H. Evaluation of a seven day course of oxytetracycline in women with chlamydial cervicitis. Eur J Clin Microbiol. 1986 Oct;5(5):591–595. doi: 10.1007/BF02017712. [DOI] [PubMed] [Google Scholar]
  58. Hodgson R., Driscoll G. L., Dodd J. K., Tyler J. P. Chlamydia trachomatis: the prevalence, trend and importance in initial infertility management. Aust N Z J Obstet Gynaecol. 1990 Aug;30(3):251–254. doi: 10.1111/j.1479-828x.1990.tb03226.x. [DOI] [PubMed] [Google Scholar]
  59. Hooton T. M., Batteiger B. E., Judson F. N., Spruance S. L., Stamm W. E. Ofloxacin versus doxycycline for treatment of cervical infection with Chlamydia trachomatis. Antimicrob Agents Chemother. 1992 May;36(5):1144–1146. doi: 10.1128/aac.36.5.1144. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Hughes E. G., Mowatt J., Spence J. E. Endocervical Chlamydia trachomatis infection in Canadian adolescents. CMAJ. 1989 Feb 1;140(3):297–301. [PMC free article] [PubMed] [Google Scholar]
  61. Ibsen H. H., Møller B. R., Halkier-Sørensen L., From E. Treatment of nongonococcal urethritis: comparison of ofloxacin and erythromycin. Sex Transm Dis. 1989 Jan-Mar;16(1):32–35. doi: 10.1097/00007435-198901000-00007. [DOI] [PubMed] [Google Scholar]
  62. Jaschek G., Gaydos C. A., Welsh L. E., Quinn T. C. Direct detection of Chlamydia trachomatis in urine specimens from symptomatic and asymptomatic men by using a rapid polymerase chain reaction assay. J Clin Microbiol. 1993 May;31(5):1209–1212. doi: 10.1128/jcm.31.5.1209-1212.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. Jones R. B., Mammel J. B., Shepard M. K., Fisher R. R. Recovery of Chlamydia trachomatis from the endometrium of women at risk for chlamydial infection. Am J Obstet Gynecol. 1986 Jul;155(1):35–39. doi: 10.1016/0002-9378(86)90073-6. [DOI] [PubMed] [Google Scholar]
  64. Kane J. L., Woodland R. M., Forsey T., Darougar S., Elder M. G. Evidence of chlamydial infection in infertile women with and without fallopian tube obstruction. Fertil Steril. 1984 Dec;42(6):843–848. doi: 10.1016/s0015-0282(16)48254-3. [DOI] [PubMed] [Google Scholar]
  65. Karam G. H., Martin D. H., Flotte T. R., Bonnarens F. O., Joseph J. R., Mroczkowski T. F., Johnson W. D. Asymptomatic Chlamydia trachomatis infections among sexually active men. J Infect Dis. 1986 Nov;154(5):900–903. doi: 10.1093/infdis/154.5.900. [DOI] [PubMed] [Google Scholar]
  66. Katz B. P., Caine V. A., Batteiger B. E., Jones R. B. A randomized trial to compare 7- and 21-day tetracycline regimens in the prevention of recurrence of infection with Chlamydia trachomatis. Sex Transm Dis. 1991 Jan-Mar;18(1):36–40. doi: 10.1097/00007435-199101000-00008. [DOI] [PubMed] [Google Scholar]
  67. Kawada Y., Lee J. M., Saito I., Lai C., Chang L. S., Limson B. M., Polnikorn N., Daili S. F. Ofloxacin treatment of nongonococcal urethritis. A multi-center study in Asia. Arzneimittelforschung. 1990 Feb;40(2 Pt 1):190–192. [PubMed] [Google Scholar]
  68. Khurana C. M., Deddish P. A., delMundo F. Prevalence of Chlamydia trachomatis in the pregnant cervix. Obstet Gynecol. 1985 Aug;66(2):241–243. [PubMed] [Google Scholar]
  69. Kitchen V. S., Donegan C., Ward H., Thomas B., Harris J. R., Taylor-Robinson D. Comparison of ofloxacin with doxycycline in the treatment of non-gonococcal urethritis and cervical chlamydial infection. J Antimicrob Chemother. 1990 Nov;26 (Suppl 500):99–105. doi: 10.1093/jac/26.suppl_d.99. [DOI] [PubMed] [Google Scholar]
  70. Kiviat N. B., Wølner-Hanssen P., Peterson M., Wasserheit J., Stamm W. E., Eschenbach D. A., Paavonen J., Lingenfelter J., Bell T., Zabriskie V. Localization of Chlamydia trachomatis infection by direct immunofluorescence and culture in pelvic inflammatory disease. Am J Obstet Gynecol. 1986 Apr;154(4):865–873. doi: 10.1016/0002-9378(86)90473-4. [DOI] [PubMed] [Google Scholar]
  71. Kluytmans J. A., Goessens W. H., Mouton J. W., van Rijsoort-Vos J. H., Niesters H. G., Quint W. G., Habbema L., Stolz E., Wagenvoort J. H. Evaluation of Clearview and Magic Lite tests, polymerase chain reaction, and cell culture for detection of Chlamydia trachomatis in urogenital specimens. J Clin Microbiol. 1993 Dec;31(12):3204–3210. doi: 10.1128/jcm.31.12.3204-3210.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Kojima H., Wang S. P., Kuo C. C., Grayston J. T. Local antibody in semen for rapid diagnosis of Chlamydia trachomatis epididymitis. J Urol. 1988 Sep;140(3):528–531. doi: 10.1016/s0022-5347(17)41710-1. [DOI] [PubMed] [Google Scholar]
  73. Kosseim M., Brunham R. C. Fallopian tube obstruction as a sequela to Chlamydia trachomatis infection. Eur J Clin Microbiol. 1986 Oct;5(5):584–590. doi: 10.1007/BF02017711. [DOI] [PubMed] [Google Scholar]
  74. Kovacs G. T., Westcott M., Rusden J., Asche V., King H., Haynes S. E., Moore E. K., Hall B. E. A prospective single-blind trial of minocycline and doxycycline in the treatment of genital Chlamydia trachomatis infection in women. Med J Aust. 1989 May 1;150(9):483–485. doi: 10.5694/j.1326-5377.1989.tb136591.x. [DOI] [PubMed] [Google Scholar]
  75. Krowchuk D. P., Anglin T. M., Lembo R. M., Brown R. F., Thomas F., Kumar M. L. Use of enzyme immunoassay for the rapid diagnosis of Chlamydia trachomatis endocervical infection in female adolescents. J Adolesc Health Care. 1988 Jul;9(4):296–300. doi: 10.1016/0197-0070(88)90253-7. [DOI] [PubMed] [Google Scholar]
  76. Larsen J. H., Wulf H. C., Friis-Møller A. Comparison of a fluorescent monoclonal antibody assay and a tissue culture assay for routine detection of infections caused by Chlamydia trachomatis. Eur J Clin Microbiol. 1986 Oct;5(5):554–558. doi: 10.1007/BF02017704. [DOI] [PubMed] [Google Scholar]
  77. Lassus A. B., Virrankoski T., Reitamo S. J., Kartamaa M., Happonen H. P., Saikku P. A., Karvonen P. K., Lassus J. E. Pivampicillin versus doxycycline in the treatment of chlamydial urethritis in men. Sex Transm Dis. 1990 Jan-Mar;17(1):20–22. [PubMed] [Google Scholar]
  78. Lassus A. Comparative studies of azithromycin in skin and soft-tissue infections and sexually transmitted infections by Neisseria and Chlamydia species. J Antimicrob Chemother. 1990 Jan;25 (Suppl A):115–121. doi: 10.1093/jac/25.suppl_a.115. [DOI] [PubMed] [Google Scholar]
  79. Lassus A., Karppinen L., Ingervo L., Jeskanen L., Reitamo S., Happonen H. P., Karkulahti R. Ciprofloxacin versus amoxycillin and probenecid in the treatment of uncomplicated gonorrhoea. Scand J Infect Dis Suppl. 1989;60:58–61. [PubMed] [Google Scholar]
  80. Lauharanta J., Saarinen K., Mustonen M. T., Happonen H. P. Single-dose oral azithromycin versus seven-day doxycycline in the treatment of non-gonococcal urethritis in males. J Antimicrob Chemother. 1993 Jun;31 (Suppl E):177–183. doi: 10.1093/jac/31.suppl_e.177. [DOI] [PubMed] [Google Scholar]
  81. Lee H. H., Chernesky M. A., Schachter J., Burczak J. D., Andrews W. W., Muldoon S., Leckie G., Stamm W. E. Diagnosis of Chlamydia trachomatis genitourinary infection in women by ligase chain reaction assay of urine. Lancet. 1995 Jan 28;345(8944):213–216. doi: 10.1016/s0140-6736(95)90221-x. [DOI] [PubMed] [Google Scholar]
  82. Levallois P., Rioux J. E., Côté L. Chlamydial infection among females attending an abortion clinic: prevalence and risk factors. CMAJ. 1987 Jul 1;137(1):33–37. [PMC free article] [PubMed] [Google Scholar]
  83. Linnemann C. C., Jr, Heaton C. L., Ritchey M. Treatment of Chlamydia trachomatis infections: comparison of 1- and 2-g doses of erythromycin daily for seven days. Sex Transm Dis. 1987 Apr-Jun;14(2):102–106. [PubMed] [Google Scholar]
  84. Lipkin E. S., Moncada J. V., Shafer M. A., Wilson T. E., Schachter J. Comparison of monoclonal antibody staining and culture in diagnosing cervical chlamydial infection. J Clin Microbiol. 1986 Jan;23(1):114–117. doi: 10.1128/jcm.23.1.114-117.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  85. Lisby G., Scheibel J., Abrahamsson L. O., Christensen E. S., Paloheimo S. Detection of Chlamydia trachomatis in individual and pooled endocervical and urethral scrapes by a commercially available polymerase chain reaction. APMIS. 1994 Oct;102(10):797–800. [PubMed] [Google Scholar]
  86. Lister P. J., Balechandran T., Ridgway G. L., Robinson A. J. Comparison of azithromycin and doxycycline in the treatment of non-gonococcal urethritis in men. J Antimicrob Chemother. 1993 Jun;31 (Suppl E):185–192. doi: 10.1093/jac/31.suppl_e.185. [DOI] [PubMed] [Google Scholar]
  87. Lunenfeld E., Shapiro B. S., Sarov B., Sarov I., Insler V., Decherney A. H. The association between chlamydial-specific IgG and IgA antibodies and pregnancy outcome in an in vitro fertilization program. J In Vitro Fert Embryo Transf. 1989 Aug;6(4):222–227. doi: 10.1007/BF01132869. [DOI] [PubMed] [Google Scholar]
  88. Magat A. H., Alger L. S., Nagey D. A., Hatch V., Lovchik J. C. Double-blind randomized study comparing amoxicillin and erythromycin for the treatment of Chlamydia trachomatis in pregnancy. Obstet Gynecol. 1993 May;81(5 ):745–749. [PubMed] [Google Scholar]
  89. Magder L. S., Klontz K. C., Bush L. H., Barnes R. C. Effect of patient characteristics on performance of an enzyme immunoassay for detecting cervical Chlamydia trachomatis infection. J Clin Microbiol. 1990 Apr;28(4):781–784. doi: 10.1128/jcm.28.4.781-784.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  90. Maguire N. C., Jordan A. G., Ehya H. Detection of Chlamydia trachomatis in cervical smears from pregnant population. Arch Pathol Lab Med. 1990 Feb;114(2):204–207. [PubMed] [Google Scholar]
  91. Mahony J. B., Luinstra K. E., Sellors J. W., Jang D., Chernesky M. A. Confirmatory polymerase chain reaction testing for Chlamydia trachomatis in first-void urine from asymptomatic and symptomatic men. J Clin Microbiol. 1992 Sep;30(9):2241–2245. doi: 10.1128/jcm.30.9.2241-2245.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  92. Mahony J. B., Luinstra K. E., Sellors J. W., Pickard L., Chong S., Jang D., Chernesky M. A. Role of confirmatory PCRs in determining performance of Chlamydia Amplicor PCR with endocervical specimens from women with a low prevalence of infection. J Clin Microbiol. 1994 Oct;32(10):2490–2493. doi: 10.1128/jcm.32.10.2490-2493.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  93. Maiti H., Chowdhury F. H., Richmond S. J., Stirland R. M., Tooth J. A., Bhattacharyya M. N., Stock J. K. Ofloxacin in the treatment of uncomplicated gonorrhea and chlamydial genital infection. Clin Ther. 1991 Jul-Aug;13(4):441–447. [PubMed] [Google Scholar]
  94. Majeroni B. A. Chlamydial cervicitis: complications and new treatment options. Am Fam Physician. 1994 Jun;49(8):1825-9, 1832. [PubMed] [Google Scholar]
  95. Martens M. G., Gordon S., Yarborough D. R., Faro S., Binder D., Berkeley A. Multicenter randomized trial of ofloxacin versus cefoxitin and doxycycline in outpatient treatment of pelvic inflammatory disease. Ambulatory PID Research Group. South Med J. 1993 Jun;86(6):604–610. doi: 10.1097/00007611-199306000-00002. [DOI] [PubMed] [Google Scholar]
  96. Martin D. H., Mroczkowski T. F., Dalu Z. A., McCarty J., Jones R. B., Hopkins S. J., Johnson R. B. A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. The Azithromycin for Chlamydial Infections Study Group. N Engl J Med. 1992 Sep 24;327(13):921–925. doi: 10.1056/NEJM199209243271304. [DOI] [PubMed] [Google Scholar]
  97. Massé R., Laperrière H., Rousseau H., Lefebvre J., Remis R. S. Chlamydia trachomatis cervical infection: prevalence and determinants among women presenting for routine gynecologic examination. CMAJ. 1991 Oct 15;145(8):953–961. [PMC free article] [PubMed] [Google Scholar]
  98. McCormack W. M., Rosner B., Lee Y. H., Munoz A., Charles D., Kass E. H. Effect on birth weight of erythromycin treatment of pregnant women. Obstet Gynecol. 1987 Feb;69(2):202–207. [PubMed] [Google Scholar]
  99. McMillan J. A., Weiner L. B., Lamberson H. V., Hagen J. H., Aubry R. H., Abdul-Karim R. W., Sunderji S. G., Higgins A. P. Efficacy of maternal screening and therapy in the prevention of chlamydia infection of the newborn. Infection. 1985 Nov-Dec;13(6):263–266. doi: 10.1007/BF01645435. [DOI] [PubMed] [Google Scholar]
  100. Miettinen A., Heinonen P. K., Teisala K., Hakkarainen K., Punnonen R. Serologic evidence for the role of Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma hominis in the etiology of tubal factor infertility and ectopic pregnancy. Sex Transm Dis. 1990 Jan-Mar;17(1):10–14. [PubMed] [Google Scholar]
  101. Miyashita N., Lijima Y., Matsumoto A. Evaluation of the sensitivity and specificity of polymerase chain reaction test kit, AMPLICOR Chlamydia trachomatis. Microbiol Immunol. 1994;38(1):81–85. doi: 10.1111/j.1348-0421.1994.tb01747.x. [DOI] [PubMed] [Google Scholar]
  102. Mogabgab W. J., Holmes B., Murray M., Beville R., Lutz F. B., Tack K. J. Randomized comparison of ofloxacin and doxycycline for chlamydia and ureaplasma urethritis and cervicitis. Chemotherapy. 1990;36(1):70–76. doi: 10.1159/000238750. [DOI] [PubMed] [Google Scholar]
  103. Moncada J., Schachter J., Bolan G., Engelman J., Howard L., Mushahwar I., Ridgway G., Mumtaz G., Stamm W., Clark A. Confirmatory assay increases specificity of the chlamydiazyme test for Chlamydia trachomatis infection of the cervix. J Clin Microbiol. 1990 Aug;28(8):1770–1773. doi: 10.1128/jcm.28.8.1770-1773.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  104. Moncada J., Schachter J., Shipp M., Bolan G., Wilber J. Cytobrush in collection of cervical specimens for detection of Chlamydia trachomatis. J Clin Microbiol. 1989 Aug;27(8):1863–1866. doi: 10.1128/jcm.27.8.1863-1866.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  105. Moscicki B., Shafer M. A., Millstein S. G., Irwin C. E., Jr, Schachter J. The use and limitations of endocervical Gram stains and mucopurulent cervicitis as predictors for Chlamydia trachomatis in female adolescents. Am J Obstet Gynecol. 1987 Jul;157(1):65–71. doi: 10.1016/s0002-9378(87)80347-2. [DOI] [PubMed] [Google Scholar]
  106. Moss T. R., Hawkswell J. Evidence of infection with Chlamydia trachomatis in patients with pelvic inflammatory disease: value of partner investigation. Fertil Steril. 1986 Mar;45(3):429–430. doi: 10.1016/s0015-0282(16)49232-0. [DOI] [PubMed] [Google Scholar]
  107. Mumtaz G., Mellars B. J., Ridgway G. L., Oriel J. D. Enzyme immunoassay for the detection of Chlamydia trachomatis antigen in urethral and endocervical swabs. J Clin Pathol. 1985 Jul;38(7):740–742. doi: 10.1136/jcp.38.7.740. [DOI] [PMC free article] [PubMed] [Google Scholar]
  108. Mumtaz G., Ridgway G. L., Nayagam A., Oriel J. D. Enzyme immunoassay compared with cell culture and immunofluorescence for detecting genital chlamydia. J Clin Pathol. 1989 Jun;42(6):658–660. doi: 10.1136/jcp.42.6.658. [DOI] [PMC free article] [PubMed] [Google Scholar]
  109. Märdh P. A., Lind I., Svensson L., Weström L., Møller B. R. Antibodies to Chlamydia trachomatis, Mycoplasma hominis, and Neisseria gonorrhoeae in sera from patients with acute salpingitis. Br J Vener Dis. 1981 Apr;57(2):125–129. doi: 10.1136/sti.57.2.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  110. Mårdh P. A., Zeeberg B. Toxic effect of sampling swabs and transportation test tubes on the formation of intracytoplasmic inclusions of Chlamydia trachomatis in McCoy cell cultures. Br J Vener Dis. 1981 Aug;57(4):268–272. doi: 10.1136/sti.57.4.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  111. Nayagam A. T., Ridgway G. L., Oriel J. D. Efficacy of ofloxacin in the treatment of non-gonococcal urethritis in men and genital infections caused by Chlamydia trachomatis in men and women. J Antimicrob Chemother. 1988 Sep;22 (Suppl 100):155–158. doi: 10.1093/jac/22.supplement_c.155. [DOI] [PubMed] [Google Scholar]
  112. Nettleman M. D., Bell T. A. Cost-effectiveness of prenatal testing for Chlamydia trachomatis. Am J Obstet Gynecol. 1991 May;164(5 Pt 1):1289–1294. doi: 10.1016/0002-9378(91)90701-r. [DOI] [PubMed] [Google Scholar]
  113. Nettleman M. D., Jones R. B., Roberts S. D., Katz B. P., Washington A. E., Dittus R. S., Quinn T. S. Cost-effectiveness of culturing for Chlamydia trachomatis. A study in a clinic for sexually transmitted diseases. Ann Intern Med. 1986 Aug;105(2):189–196. doi: 10.7326/0003-4819-105-2-189. [DOI] [PubMed] [Google Scholar]
  114. Nielsen P. B., Christensen J. D., Frentz G. A comparison of oxytetracycline and trimethoprim in the treatment of Chlamydia trachomatis urethritis. Infection. 1984 Jul-Aug;12(4):274–275. doi: 10.1007/BF01645960. [DOI] [PubMed] [Google Scholar]
  115. Nuovo J., Melnikow J., Paliescheskey M., King J., Mowers R. Cost-effectiveness analysis of five different antibiotic regimens for the treatment of uncomplicated Chlamydia trachomatis cervicitis. J Am Board Fam Pract. 1995 Jan-Feb;8(1):7–16. [PubMed] [Google Scholar]
  116. Oriel J. D., Ridgway G. L. Comparison of tetracycline and minocycline in the treatment of non-gonococcal urethritis. Br J Vener Dis. 1983 Aug;59(4):245–248. doi: 10.1136/sti.59.4.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  117. Oskarsson T., Geirsson R. T., Steingrímsson O., Thorarinsson H. Lower genital tract infection with Neisseria gonorrhoeae and Chlamydia trachomatis in women requesting induced abortion and in their sexual partners. Acta Obstet Gynecol Scand. 1990;69(7-8):635–640. doi: 10.3109/00016349009028709. [DOI] [PubMed] [Google Scholar]
  118. Osser S., Persson K. Epidemiologic and serodiagnostic aspects of chlamydial salpingitis. Obstet Gynecol. 1982 Feb;59(2):206–209. [PubMed] [Google Scholar]
  119. Osser S., Persson K., Liedholm P. Tubal infertility and silent chlamydial salpingitis. Hum Reprod. 1989 Apr;4(3):280–284. doi: 10.1093/oxfordjournals.humrep.a136888. [DOI] [PubMed] [Google Scholar]
  120. Ostergaard L., Birkelund S., Christiansen G. Use of polymerase chain reaction for detection of Chlamydia trachomatis. J Clin Microbiol. 1993 Nov;31(11):3081–3081. doi: 10.1128/jcm.31.11.3081-.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  121. Paavonen J., Aine R., Teisala K., Heinonen P. K., Punnonen R., Lehtinen M., Miettinen A., Grönroos P. Chlamydial endometritis. J Clin Pathol. 1985 Jul;38(7):726–732. doi: 10.1136/jcp.38.7.726. [DOI] [PMC free article] [PubMed] [Google Scholar]
  122. Paavonen J., Roberts P. L., Stevens C. E., Wølner-Hanssen P., Brunham R. C., Hillier S., Stamm W. E., Kuo C. C., DeRouen T., Holmes K. K. Randomized treatment of mucopurulent cervicitis with doxycycline or amoxicillin. Am J Obstet Gynecol. 1989 Jul;161(1):128–135. doi: 10.1016/0002-9378(89)90249-4. [DOI] [PubMed] [Google Scholar]
  123. Pastorek J. G., 2nd, Mroczkowski T. F., Martin D. H. Fine-tuning the fluorescent antibody test for chlamydial infections in pregnancy. Obstet Gynecol. 1988 Dec;72(6):957–960. doi: 10.1097/00006250-198812000-00033. [DOI] [PubMed] [Google Scholar]
  124. Patton D. L., Askienazy-Elbhar M., Henry-Suchet J., Campbell L. A., Cappuccio A., Tannous W., Wang S. P., Kuo C. C. Detection of Chlamydia trachomatis in fallopian tube tissue in women with postinfectious tubal infertility. Am J Obstet Gynecol. 1994 Jul;171(1):95–101. doi: 10.1016/s0002-9378(94)70084-2. [DOI] [PubMed] [Google Scholar]
  125. Phillips R. S., Aronson M. D., Taylor W. C., Safran C. Should tests for Chlamydia trachomatis cervical infection be done during routine gynecologic visits? An analysis of the costs of alternative strategies. Ann Intern Med. 1987 Aug;107(2):188–194. doi: 10.7326/0003-4819-107-2-188. [DOI] [PubMed] [Google Scholar]
  126. Phillips R. S., Hanff P. A., Kauffman R. S., Aronson M. D. Use of a direct fluorescent antibody test for detecting Chlamydia trachomatis cervical infection in women seeking routine gynecologic care. J Infect Dis. 1987 Oct;156(4):575–581. doi: 10.1093/infdis/156.4.575. [DOI] [PubMed] [Google Scholar]
  127. Porder K., Sanchez N., Roblin P. M., McHugh M., Hammerschlag M. R. Lack of specificity of Chlamydiazyme for detection of vaginal chlamydial infection in prepubertal girls. Pediatr Infect Dis J. 1989 Jun;8(6):358–360. doi: 10.1097/00006454-198906000-00006. [DOI] [PubMed] [Google Scholar]
  128. Preece P. M., Anderson J. M., Thompson R. G. Chlamydia trachomatis infection in infants: a prospective study. Arch Dis Child. 1989 Apr;64(4):525–529. doi: 10.1136/adc.64.4.525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  129. Puolakkainen M., Vesterinen E., Purola E., Saikku P., Paavonen J. Persistence of chlamydial antibodies after pelvic inflammatory disease. J Clin Microbiol. 1986 May;23(5):924–928. doi: 10.1128/jcm.23.5.924-928.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  130. Rasmussen S. J., Smith-Vaughan H., Nelson M., Chan S. W., Timms P., Capon A. G. Detection of Chlamydia trachomatis in urine using enzyme immunoassay and DNA amplification. Mol Cell Probes. 1993 Dec;7(6):425–430. doi: 10.1006/mcpr.1993.1063. [DOI] [PubMed] [Google Scholar]
  131. Reichart C. A., Gaydos C. A., Brady W. E., Quinn T. C., Hook E. W., 3rd Evaluation of Abbott Testpack Chlamydia for detection of Chlamydia trachomatis in patients attending sexually transmitted diseases clinics. Sex Transm Dis. 1990 Jul-Sep;17(3):147–151. doi: 10.1097/00007435-199007000-00007. [DOI] [PubMed] [Google Scholar]
  132. Richmond S. J., Bhattacharyya M. N., Maiti H., Chowdhury F. H., Stirland R. M., Tooth J. A. The efficacy of ofloxacin against infection caused by Neisseria gonorrhoeae and Chlamydia trachomatis. J Antimicrob Chemother. 1988 Sep;22 (Suppl 100):149–153. doi: 10.1093/jac/22.supplement_c.149. [DOI] [PubMed] [Google Scholar]
  133. Robertson J. N., Hogston P., Ward M. E. Gonococcal and chlamydial antibodies in ectopic and intrauterine pregnancy. Br J Obstet Gynaecol. 1988 Jul;95(7):711–716. doi: 10.1111/j.1471-0528.1988.tb06535.x. [DOI] [PubMed] [Google Scholar]
  134. Robson H. G., Shah P. P., Lalonde R. G., Hayes L., Senikas V. M. Comparison of rosaramicin and erythromycin stearate for treatment of cervical infection with Chlamydia trachomatis. Sex Transm Dis. 1983 Jul-Sep;10(3):130–134. doi: 10.1097/00007435-198307000-00006. [DOI] [PubMed] [Google Scholar]
  135. Romanowski B., Talbot H., Stadnyk M., Kowalchuk P., Bowie W. R. Minocycline compared with doxycycline in the treatment of nongonococcal urethritis and mucopurulent cervicitis. Ann Intern Med. 1993 Jul 1;119(1):16–22. doi: 10.7326/0003-4819-119-1-199307010-00003. [DOI] [PubMed] [Google Scholar]
  136. Rompalo A. M., Price C. B., Roberts P. L., Stamm W. E. Potential value of rectal-screening cultures for Chlamydia trachomatis in homosexual men. J Infect Dis. 1986 May;153(5):888–892. doi: 10.1093/infdis/153.5.888. [DOI] [PubMed] [Google Scholar]
  137. Rowland G. F., Forsey T., Moss T. R., Steptoe P. C., Hewitt J., Darougar S. Failure of in vitro fertilization and embryo replacement following infection with Chlamydia trachomatis. J In Vitro Fert Embryo Transf. 1985 Sep;2(3):151–155. doi: 10.1007/BF01131503. [DOI] [PubMed] [Google Scholar]
  138. Ryan G. M., Jr, Abdella T. N., McNeeley S. G., Baselski V. S., Drummond D. E. Chlamydia trachomatis infection in pregnancy and effect of treatment on outcome. Am J Obstet Gynecol. 1990 Jan;162(1):34–39. doi: 10.1016/0002-9378(90)90815-o. [DOI] [PubMed] [Google Scholar]
  139. Sanders L. L., Jr, Harrison H. R., Washington A. E. Treatment of sexually transmitted chlamydial infections. JAMA. 1986 Apr 4;255(13):1750–1756. [PubMed] [Google Scholar]
  140. Schachter J., Grossman M., Holt J., Sweet R., Goodner E., Mills J. Prospective study of chlamydial infection in neonates. Lancet. 1979 Aug 25;2(8139):377–380. doi: 10.1016/s0140-6736(79)90400-8. [DOI] [PubMed] [Google Scholar]
  141. Schachter J., Sweet R. L., Grossman M., Landers D., Robbie M., Bishop E. Experience with the routine use of erythromycin for chlamydial infections in pregnancy. N Engl J Med. 1986 Jan 30;314(5):276–279. doi: 10.1056/NEJM198601303140503. [DOI] [PubMed] [Google Scholar]
  142. Schiøtz H. A., Schøyen R. Performance of Chlamydiazyme enzyme immunoassay for detecting Chlamydia trachomatis in cervical specimens. Int J STD AIDS. 1990 Sep;1(5):357–359. doi: 10.1177/095646249000100511. [DOI] [PubMed] [Google Scholar]
  143. Sellors J. W., Mahony J. B., Jang D., Pickard L., Goldsmith C. H., Gafni A., Chernesky M. A. Comparison of cervical, urethral, and urine specimens for the detection of Chlamydia trachomatis in women. J Infect Dis. 1991 Jul;164(1):205–208. doi: 10.1093/infdis/164.1.205. [DOI] [PubMed] [Google Scholar]
  144. Sellors J. W., Mahony J. B., Pickard L., Jang D., Groves D., Luinstra K. E., Chernesky M. A. Screening urine with a leukocyte esterase strip and subsequent chlamydial testing of asymptomatic men attending primary care practitioners. Sex Transm Dis. 1993 May-Jun;20(3):152–157. doi: 10.1097/00007435-199305000-00007. [DOI] [PubMed] [Google Scholar]
  145. Sellors J. W., Pickard L., Gafni A., Goldsmith C. H., Jang D., Mahony J. B., Chernesky M. A. Effectiveness and efficiency of selective vs universal screening for chlamydial infection in sexually active young women. Arch Intern Med. 1992 Sep;152(9):1837–1844. [PubMed] [Google Scholar]
  146. Sellors J., Mahony J., Jang D., Pickard L., Castriciano S., Landis S., Stewart I., Seidelman W., Cunningham I., Chernesky M. Rapid, on-site diagnosis of chlamydial urethritis in men by detection of antigens in urethral swabs and urine. J Clin Microbiol. 1991 Feb;29(2):407–409. doi: 10.1128/jcm.29.2.407-409.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  147. Shafer M. A., Schachter J., Moncada J., Keogh J., Pantell R., Gourlay L., Eyre S., Boyer C. B. Evaluation of urine-based screening strategies to detect Chlamydia trachomatis among sexually active asymptomatic young males. JAMA. 1993 Nov 3;270(17):2065–2070. [PubMed] [Google Scholar]
  148. Shafer M. A., Vaughan E., Lipkin E. S., Moscicki B. A., Schachter J. Evaluation of fluorescein-conjugated monoclonal antibody test to detect Chlamydia trachomatis endocervical infections in adolescent girls. J Pediatr. 1986 May;108(5 Pt 1):779–783. doi: 10.1016/s0022-3476(86)81068-x. [DOI] [PubMed] [Google Scholar]
  149. Shepard M. K., Jones R. B. Recovery of Chlamydia trachomatis from endometrial and fallopian tube biopsies in women with infertility of tubal origin. Fertil Steril. 1989 Aug;52(2):232–238. doi: 10.1016/s0015-0282(16)60847-6. [DOI] [PubMed] [Google Scholar]
  150. Silverman N. S., Sullivan M., Hochman M., Womack M., Jungkind D. L. A randomized, prospective trial comparing amoxicillin and erythromycin for the treatment of Chlamydia trachomatis in pregnancy. Am J Obstet Gynecol. 1994 Mar;170(3):829–832. doi: 10.1016/s0002-9378(94)70292-6. [DOI] [PubMed] [Google Scholar]
  151. Smith B. L., Cummings M. C., Covino J. M., Benes S., Draft K., McCormack W. M. Evaluation of ofloxacin in the treatment of uncomplicated gonorrhea. Sex Transm Dis. 1991 Jan-Mar;18(1):18–20. doi: 10.1097/00007435-199101000-00004. [DOI] [PubMed] [Google Scholar]
  152. Smith I. W., Morrison C. L., Patrizio C., McMillan A. Use of a commercial PCR kit for detecting Chlamydia trachomatis. J Clin Pathol. 1993 Sep;46(9):822–825. doi: 10.1136/jcp.46.9.822. [DOI] [PMC free article] [PubMed] [Google Scholar]
  153. Smith T. F., Weed L. A. Evaluation of calcium alginate-tipped aluminum swabs transported in Culturettes containing ampules of 2-sucrose phosphate medium for recovery of Chlamydia trachomatis. Am J Clin Pathol. 1983 Aug;80(2):213–215. doi: 10.1093/ajcp/80.2.213. [DOI] [PubMed] [Google Scholar]
  154. Stamm W. E., Harrison H. R., Alexander E. R., Cles L. D., Spence M. R., Quinn T. C. Diagnosis of Chlamydia trachomatis infections by direct immunofluorescence staining of genital secretions. A multicenter trial. Ann Intern Med. 1984 Nov;101(5):638–641. doi: 10.7326/0003-4819-101-5-638. [DOI] [PubMed] [Google Scholar]
  155. Stamm W. E., Koutsky L. A., Benedetti J. K., Jourden J. L., Brunham R. C., Holmes K. K. Chlamydia trachomatis urethral infections in men. Prevalence, risk factors, and clinical manifestations. Ann Intern Med. 1984 Jan;100(1):47–51. doi: 10.7326/0003-4819-100-1-47. [DOI] [PubMed] [Google Scholar]
  156. Stary A., Kopp W., Zahel B., Müller I., Nerad S., Storch M. Rapid diagnosis of Chlamydia trachomatis with a nucleic acid probe in male and female patients. Dermatology. 1994;188(4):300–304. doi: 10.1159/000247171. [DOI] [PubMed] [Google Scholar]
  157. Steingrimsson O., Olafsson J. H., Thorarinsson H., Ryan R. W., Johnson R. B., Tilton R. C. Azithromycin in the treatment of sexually transmitted disease. J Antimicrob Chemother. 1990 Jan;25 (Suppl A):109–114. doi: 10.1093/jac/25.suppl_a.109. [DOI] [PubMed] [Google Scholar]
  158. Steingrímsson O., Olafsson J. H., Thórarinsson H., Ryan R. W., Johnson R. B., Tilton R. C. Single dose azithromycin treatment of gonorrhea and infections caused by C. trachomatis and U. urealyticum in men. Sex Transm Dis. 1994 Jan-Feb;21(1):43–46. doi: 10.1097/00007435-199401000-00009. [DOI] [PubMed] [Google Scholar]
  159. Stenberg K., Mårdh P. A. Treatment of chlamydial conjunctivitis in newborns and adults with erythromycin and roxithromycin. J Antimicrob Chemother. 1991 Aug;28(2):301–307. doi: 10.1093/jac/28.2.301. [DOI] [PubMed] [Google Scholar]
  160. Svensson L., Mårdh P. A., Ahlgren M., Nordenskjöld F. Ectopic pregnancy and antibodies to Chlamydia trachomatis. Fertil Steril. 1985 Sep;44(3):313–317. [PubMed] [Google Scholar]
  161. Svensson L., Mårdh P. A., Weström L. Infertility after acute salpingitis with special reference to Chlamydia trachomatis. Fertil Steril. 1983 Sep;40(3):322–329. doi: 10.1016/s0015-0282(16)47294-8. [DOI] [PubMed] [Google Scholar]
  162. Svensson L., Weström L., Mårdh P. A. Acute salpingitis with Chlamydia trachomatis isolated from the fallopian tubes: clinical, cultural, and serologic findings. Sex Transm Dis. 1981 Apr-Jun;8(2):51–55. doi: 10.1097/00007435-198104000-00002. [DOI] [PubMed] [Google Scholar]
  163. Sweet R. L., Wiesenfeld H. C., Uhrin M., Dixon B. Comparison of EIA, culture, and polymerase chain reaction for Chlamydia trachomatis in a sexually transmitted disease clinic. J Infect Dis. 1994 Aug;170(2):500–501. doi: 10.1093/infdis/170.2.500-a. [DOI] [PubMed] [Google Scholar]
  164. Tam M. R., Stamm W. E., Handsfield H. H., Stephens R., Kuo C. C., Holmes K. K., Ditzenberger K., Krieger M., Nowinski R. C. Culture-independent diagnosis of Chlamydia trachomatis using monoclonal antibodies. N Engl J Med. 1984 May 3;310(18):1146–1150. doi: 10.1056/NEJM198405033101803. [DOI] [PubMed] [Google Scholar]
  165. Taylor-Robinson D., Thomas B. J. Laboratory techniques for the diagnosis of chlamydial infections. Genitourin Med. 1991 Jun;67(3):256–266. doi: 10.1136/sti.67.3.256. [DOI] [PMC free article] [PubMed] [Google Scholar]
  166. Thambar I. V., Simmons P. D., Thin R. N., Darougar S., Yearsley P. Double-blind comparison of two regimens in the treatment of nongonococcal urethritis. Seven-day vs 21-day course of triple tetracyclinc (Deteclo). Br J Vener Dis. 1979 Aug;55(4):284–288. doi: 10.1136/sti.55.4.284. [DOI] [PMC free article] [PubMed] [Google Scholar]
  167. Thejls H., Gnarpe J., Gnarpe H., Larsson P. G., Platz-Christensen J. J., Ostergaard L., Victor A. Expanded gold standard in the diagnosis of Chlamydia trachomatis in a low prevalence population: diagnostic efficacy of tissue culture, direct immunofluorescence, enzyme immunoassay, PCR and serology. Genitourin Med. 1994 Oct;70(5):300–303. doi: 10.1136/sti.70.5.300. [DOI] [PMC free article] [PubMed] [Google Scholar]
  168. Thejls H., Gnarpe J., Lundkvist O., Heimer G., Larsson G., Victor A. Diagnosis and prevalence of persistent chlamydia infection in infertile women: tissue culture, direct antigen detection, and serology. Fertil Steril. 1991 Feb;55(2):304–310. [PubMed] [Google Scholar]
  169. Theunissen J. J., Minderhoud-Bassie W., Wagenvoort J. H., Stolz E., Michel M. F., Huikeshoven F. J. Chlamydia trachomatis-specific antibodies in patients with pelvic inflammatory disease: comparison with isolation in tissue culture or detection with polymerase chain reaction. Genitourin Med. 1994 Oct;70(5):304–307. doi: 10.1136/sti.70.5.304. [DOI] [PMC free article] [PubMed] [Google Scholar]
  170. Thomason J. L., Kellett A. V., Gelbart S. M., James J. A., Broekhuizen F. F. Short-course erythromycin therapy for endocervical chlamydia during pregnancy. J Fam Pract. 1990 Jun;30(6):711–712. [PubMed] [Google Scholar]
  171. Thompson S. E., Washington A. E. Epidemiology of sexually transmitted Chlamydia trachomatis infections. Epidemiol Rev. 1983;5:96–123. doi: 10.1093/oxfordjournals.epirev.a036266. [DOI] [PubMed] [Google Scholar]
  172. Uyeda C. T., Welborn P., Ellison-Birang N., Shunk K., Tsaouse B. Rapid diagnosis of chlamydial infections with the MicroTrak direct test. J Clin Microbiol. 1984 Nov;20(5):948–950. doi: 10.1128/jcm.20.5.948-950.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  173. Walters M. D., Eddy C. A., Gibbs R. S., Schachter J., Holden A. E., Pauerstein C. J. Antibodies to Chlamydia trachomatis and risk for tubal pregnancy. Am J Obstet Gynecol. 1988 Oct;159(4):942–946. doi: 10.1016/s0002-9378(88)80177-7. [DOI] [PubMed] [Google Scholar]
  174. Wang S. P., Eschenbach D. A., Holmes K. K., Wager G., Grayston J. T. Chlamydia trachomatis infection in Fitz-Hugh-Curtis syndrome. Am J Obstet Gynecol. 1980 Dec 1;138(7 Pt 2):1034–1038. doi: 10.1016/0002-9378(80)91103-5. [DOI] [PubMed] [Google Scholar]
  175. Washington A. E., Arno P. S., Brooks M. A. The economic cost of pelvic inflammatory disease. JAMA. 1986 Apr 4;255(13):1735–1738. [PubMed] [Google Scholar]
  176. Washington A. E., Johnson R. E., Sanders L. L., Jr Chlamydia trachomatis infections in the United States. What are they costing us? JAMA. 1987 Apr 17;257(15):2070–2072. [PubMed] [Google Scholar]
  177. Weber J. T., Johnson R. E. New treatments for Chlamydia trachomatis genital infection. Clin Infect Dis. 1995 Apr;20 (Suppl 1):S66–S71. doi: 10.1093/clinids/20.supplement_1.s66. [DOI] [PubMed] [Google Scholar]
  178. Wein P., Kloss M., Garland S. M. Postabortal pelvic sepsis in association with Chlamydia trachomatis. Aust N Z J Obstet Gynaecol. 1990 Nov;30(4):347–350. doi: 10.1111/j.1479-828x.1990.tb02026.x. [DOI] [PubMed] [Google Scholar]
  179. Wendel G. D., Jr, Cox S. M., Bawdon R. E., Theriot S. K., Heard M. C., Nobles B. J. A randomized trial of ofloxacin versus cefoxitin and doxycycline in the outpatient treatment of acute salpingitis. Am J Obstet Gynecol. 1991 May;164(5 Pt 2):1390–1396. doi: 10.1016/0002-9378(91)91479-g. [DOI] [PubMed] [Google Scholar]
  180. Whatley J. D., Thin R. N., Mumtaz G., Ridgway G. L. Azithromycin vs doxycycline in the treatment of non-gonococcal urethritis. Int J STD AIDS. 1991 Jul-Aug;2(4):248–251. doi: 10.1177/095646249100200404. [DOI] [PubMed] [Google Scholar]
  181. Wiesenfeld H. C., Uhrin M., Dixon B. W., Sweet R. L. Diagnosis of male Chlamydia trachomatis urethritis by polymerase chain reaction. Sex Transm Dis. 1994 Sep-Oct;21(5):268–271. doi: 10.1097/00007435-199409000-00004. [DOI] [PubMed] [Google Scholar]
  182. Wiesmeier E., Bruckner D., Black M. Detection of Chlamydia trachomatis infection by direct immunofluorescence staining of genital secretion. Obstet Gynecol. 1987 Mar;69(3 Pt 1):347–349. [PubMed] [Google Scholar]
  183. Woolf S. H., Battista R. N., Anderson G. M., Logan A. G., Wang E. Assessing the clinical effectiveness of preventive maneuvers: analytic principles and systematic methods in reviewing evidence and developing clinical practice recommendations. A report by the Canadian Task Force on the Periodic Health Examination. J Clin Epidemiol. 1990;43(9):891–905. doi: 10.1016/0895-4356(90)90073-x. [DOI] [PubMed] [Google Scholar]
  184. Worm A. M., Avnstorp C., Petersen C. S. Erythromycin against Chlamydia trachomatis infections. A double blind study comparing 4- and 7-day treatment in men and women. Dan Med Bull. 1985 Oct;32(5):269–271. [PubMed] [Google Scholar]

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