Abstract
Epidemiologic knowledge of hepatitis D virus (HDV) infection is limited. A seroepidemiologic study was undertaken to determine the prevalence of the infection in Newfoundland and Labrador. Between October 1983 and October 1985 over 200 people were recognized through routine serodiagnosis and screening as having hepatitis B seromarkers. A total of 223 serum samples from 186 of these people were tested for anti-HDV. The subjects were mainly asymptomatic carriers of hepatitis B surface antigen or patients with acute or chronic hepatitis B from the native Indian and Inuit and the non-native populations. None of the serum samples were positive for anti-HDV. The absence of anti-HDV in a substantial number of people in the province who are infected with hepatitis B virus is strong evidence that HDV infection is not prevalent in the local population, including native people.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barrett D. H., Burks J. M., McMahon B., Elliott S., Berquist K. R., Bender T. R., Maynard J. E. Epidemiology of hepatitis B in two Alaska communities. Am J Epidemiol. 1977 Feb;105(2):118–122. doi: 10.1093/oxfordjournals.aje.a112362. [DOI] [PubMed] [Google Scholar]
- Hadler S. C., De Monzon M., Ponzetto A., Anzola E., Rivero D., Mondolfi A., Bracho A., Francis D. P., Gerber M. A., Thung S. Delta virus infection and severe hepatitis. An epidemic in the Yucpa Indians of Venezuela. Ann Intern Med. 1984 Mar;100(3):339–344. doi: 10.7326/0003-4819-100-3-339. [DOI] [PubMed] [Google Scholar]
- Hansson B. G., Norkrans G., Weibull M., Weiland O., Nielsen J., Leinikki P., Ukkonen P., Jensson O., Siebke J. C. Epidemiology of delta infection in Scandinavia. Prog Clin Biol Res. 1983;143:155–159. [PubMed] [Google Scholar]
- Hansson B. G. Virology and clinical significance of delta agent infection. J Virol Methods. 1985 Apr;10(4):295–298. doi: 10.1016/0166-0934(85)90045-x. [DOI] [PubMed] [Google Scholar]
- Hoy J. F., Hansson B. G., Dimitrakakis M., Gust I., Lucas C. R. Delta agent infection in Melbourne. J Med Virol. 1984;13(4):339–345. doi: 10.1002/jmv.1890130404. [DOI] [PubMed] [Google Scholar]
- Jacobson I. M., Dienstag J. L., Werner B. G., Brettler D. B., Levine P. H., Mushahwar I. K. Epidemiology and clinical impact of hepatitis D virus (delta) infection. Hepatology. 1985 Mar-Apr;5(2):188–191. doi: 10.1002/hep.1840050205. [DOI] [PubMed] [Google Scholar]
- Lindh G., Weiland O., Hansson B. G., Svedmyr A. Delta infection among patients with chronic hepatitis B in the Stockholm region. Infection. 1984 Jan-Feb;12(1):27–30. doi: 10.1007/BF01641021. [DOI] [PubMed] [Google Scholar]
- Minuk G. Y., Nicolle L. E., Postl B., Waggoner J. G., Hoofnagle J. H. Hepatitis virus infection in an isolated Canadian Inuit (Eskimo) population. J Med Virol. 1982;10(4):255–264. doi: 10.1002/jmv.1890100405. [DOI] [PubMed] [Google Scholar]
- Nath N., Mushahwar I. K., Fang C. T., Berberian H., Dodd R. Y. Antibodies to delta antigen in asymptomatic hepatitis B surface antigen-reactive blood donors in the United States and their association with other markers of hepatitis B virus. Am J Epidemiol. 1985 Aug;122(2):218–225. doi: 10.1093/oxfordjournals.aje.a114092. [DOI] [PubMed] [Google Scholar]
- Picciotto A., Celle G. Chronic delta hepatitis: a difficult problem for the hepatologist. Hepatogastroenterology. 1984 Aug;31(4):162–163. [PubMed] [Google Scholar]
- Ponzetto A., Hoofnagle J. H., Seeff L. B. Antibody to the hepatitis B virus-associated delta-agent in immune serum globulins. Gastroenterology. 1984 Dec;87(6):1213–1216. [PubMed] [Google Scholar]
- Raimondo G., Smedile A., Gallo L., Balbo A., Ponzetto A., Rizzetto M. Multicentre study of prevalence of HBV-associated delta infection and liver disease in drug-addicts. Lancet. 1982 Jan 30;1(8266):249–251. doi: 10.1016/s0140-6736(82)90976-x. [DOI] [PubMed] [Google Scholar]
- Rizzetto M., Morello C., Mannucci P. M., Gocke D. J., Spero J. A., Lewis J. H., Van Thiel D. H., Scaroni C., Peyretti F. Delta infection and liver disease in hemophilic carriers of hepatitis B surface antigen. J Infect Dis. 1982 Jan;145(1):18–22. doi: 10.1093/infdis/145.1.18. [DOI] [PubMed] [Google Scholar]
- Rizzetto M., Purcell R. H., Gerin J. L. Epidemiology of HBV-associated delta agent: geographical distribution of anti-delta and prevalence in polytransfused HBsAg carriers. Lancet. 1980 Jun 7;1(8180):1215–1218. doi: 10.1016/s0140-6736(80)91678-5. [DOI] [PubMed] [Google Scholar]
- Rizzetto M. The delta agent. Hepatology. 1983 Sep-Oct;3(5):729–737. doi: 10.1002/hep.1840030518. [DOI] [PubMed] [Google Scholar]
- Shattock A. G., Irwin F. M., Morgan B. M., Hillary I. B., Kelly M. G., Fielding J. F., Kelly D. A., Weir D. G. Increased severity and morbidity of acute hepatitis in drug abusers with simultaneously acquired hepatitis B and hepatitis D virus infections. Br Med J (Clin Res Ed) 1985 May 11;290(6479):1377–1380. doi: 10.1136/bmj.290.6479.1377. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smedile A., Farci P., Verme G., Caredda F., Cargnel A., Caporaso N., Dentico P., Trepo C., Opolon P., Gimson A. Influence of delta infection on severity of hepatitis B. Lancet. 1982 Oct 30;2(8305):945–947. doi: 10.1016/s0140-6736(82)90156-8. [DOI] [PubMed] [Google Scholar]
