Abstract
Appropriate initial surgical management of primary cutaneous malignant melanoma is important since no effective treatment exists once the tumour metastasizes. The author reviews methods of initial treatment, excisional biopsy with adequate margins being the most common. He also reports results from a questionnaire survey on the type of microstaging used at hospitals across Canada. Two thirds of the pathologists who responded to the questionnaire preferred to use both Clark's and Breslow's method of microstaging. As a result, the author believes that the best histopathologic classification to use for predicting outcome has yet to be established.
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Selected References
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- Balch C. M., Karakousis C., Mettlin C., Natarajan N., Donegan W. L., Smart C. R., Murphy G. P. Management of cutaneous melanoma in the United States. Surg Gynecol Obstet. 1984 Apr;158(4):311–318. [PubMed] [Google Scholar]
- Breslow A. Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann Surg. 1970 Nov;172(5):902–908. doi: 10.1097/00000658-197011000-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clark W. H., Jr, From L., Bernardino E. A., Mihm M. C. The histogenesis and biologic behavior of primary human malignant melanomas of the skin. Cancer Res. 1969 Mar;29(3):705–727. [PubMed] [Google Scholar]
- Davis N. C. Cutaneous melanoma. The Queensland experience. Curr Probl Surg. 1976 May;13(5):1–63. doi: 10.1016/s0011-3840(76)80013-5. [DOI] [PubMed] [Google Scholar]
- Elwood J. M., Lee J. A. Trends in mortality from primary tumours of skin in Canada. Can Med Assoc J. 1974 Apr 20;110(8):913–915. [PMC free article] [PubMed] [Google Scholar]
- Kopf A. W., Rigel D. S., Friedman R. J. The rising incidence and mortality rate of malignant melanoma. J Dermatol Surg Oncol. 1982 Sep;8(9):760–761. doi: 10.1111/j.1524-4725.1982.tb02676.x. [DOI] [PubMed] [Google Scholar]
