Abstract
Consecutive isolates of Neisseria gonorrhoeae obtained at a sexually transmitted disease clinic in Vancouver between June 1982 and June 1984 were tested for in-vitro susceptibility to eight antimicrobial agents. Of the 400 isolates 6 (1.5%) were penicillinase-producing N. gonorrhoeae, and for 25 (6.2%) the minimum inhibitory concentrations (MICs) of penicillin were 1.0 to 4.0 micrograms/ml. Ceftriaxone sodium was the most active agent. The MICs were higher than those reported in a Canadian study in 1973-74, except for tetracycline hydrochloride. The patterns of susceptibility of the isolates to one antimicrobial agent correlated significantly with those to each other agent, although the relation was weakest for trimethoprim-sulfamethoxazole and spectinomycin. The results reinforce the need to evaluate local in-vitro susceptibility patterns, especially since the proportion of isolates with relative and absolute resistance to penicillin is increasing.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bowie W. R. Epidemiology and therapy of Chlamydia trachomatis infections. Drugs. 1984 May;27(5):459–468. doi: 10.2165/00003495-198427050-00005. [DOI] [PubMed] [Google Scholar]
- Brown W. J. Modification of the rapid fermentation test for Neisseria gonorrhoeae. Appl Microbiol. 1974 Jun;27(6):1027–1030. doi: 10.1128/am.27.6.1027-1030.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chen H. Y., Williams J. D. Transferable resistance and aminoglycoside-modifying enzymes in enterococci. J Med Microbiol. 1985 Oct;20(2):187–196. doi: 10.1099/00222615-20-2-187. [DOI] [PubMed] [Google Scholar]
- Dillon J. R., Eidus L., Diena B. B. Cross-Canada survey of susceptibility of Neisseria gonorrhoeae isolates to six antimicrobial agents. Can Med Assoc J. 1978 Aug 12;119(3):223–228. [PMC free article] [PubMed] [Google Scholar]
- Handsfield H. H., Murphy V. L., Holmes K. K. Dose-ranging study of ceftriaxone for uncomplicated gonorrhea in men. Antimicrob Agents Chemother. 1981 Dec;20(6):839–840. doi: 10.1128/aac.20.6.839. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jorgensen J. H., Lee J. C., Alexander G. A. Rapid penicillinase paper strip test for detection of beta-lactamase-producing Haemophilus influenzae and Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1977 Jun;11(6):1087–1088. doi: 10.1128/aac.11.6.1087. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KELLOGG D. S., Jr, PEACOCK W. L., Jr, DEACON W. E., BROWN L., PIRKLE D. I. NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION. J Bacteriol. 1963 Jun;85:1274–1279. doi: 10.1128/jb.85.6.1274-1279.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ng W. S., Anton P., Arnold K. Neisseria gonorrhoeae strains isolated in Hong Kong: in vitro susceptibility to 13 antibiotics. Antimicrob Agents Chemother. 1981 Jan;19(1):12–17. doi: 10.1128/aac.19.1.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rajan V. S., Sng E. H., Thirumoorthy T., Goh C. L. Ceftriaxone in the treatment of ordinary and penicillinase-producing strains of Neisseria gonorrhoeae. Br J Vener Dis. 1982 Oct;58(5):314–316. doi: 10.1136/sti.58.5.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Siegel M. S., Thornsberry C., Biddle J. W., O'Mara P. R., Perine P. L., Wiesner P. J. Penicillinase-producing Neisseria gonorrhoeae: results of surveillance in the United States. J Infect Dis. 1978 Feb;137(2):170–175. doi: 10.1093/infdis/137.2.170. [DOI] [PubMed] [Google Scholar]
- Zajdowicz T. R., Sanches P. L., Berg S. W., Kerbs S. B., Newquist R. L., Harrison W. O. Comparison of ceftriaxone with cefoxitin in the treatment of penicillin-resistant gonococcal urethritis. Br J Vener Dis. 1983 Jun;59(3):176–178. doi: 10.1136/sti.59.3.176. [DOI] [PMC free article] [PubMed] [Google Scholar]