Skip to main content
NCBI home page
Annals of Surgery logoLink to Annals of Surgery
. 1987 Apr;205(4):377–384. doi: 10.1097/00000658-198704000-00006

Carcinomas arising in cystic conditions of the bile ducts. A clinical and pathologic study.

R L Rossi, M L Silverman, J W Braasch, J L Munson, S G ReMine
PMCID: PMC1492743  PMID: 3566373

Abstract

Thirty patients with cystic disease of the bile ducts operated on between 1965 and 1985 were reviewed. Three patients (10%) had a synchronous adenocarcinoma, and in three patients (10%) a metachronous carcinoma developed for a total incidence of malignancy of 20%. All patients died within 1 year of the diagnosis of malignancy. Of 19 benign cysts available for pathologic examination, one third had proliferative epithelial changes, and in two of these patients a metachronous carcinoma developed. Goblet cell metaplasia was prominent in four patients. This suggests the possibility that dysplastic changes and metaplasia of the epithelium could give rise to carcinoma. Resection of benign cysts of the bile ducts is favored, when feasible, in an attempt to decrease the incidence of malignancy.

Full text

PDF
377

Images in this article

378Fig. 1.
on p.378
378Fig. 2.
on p.378
379Fig. 3.
on p.379
379Fig. 4.
on p.379
380Fig. 5.
on p.380
381Fig. 6.
on p.381
381Fig. 7.
on p.381
382Fig. 8.
on p.382
382Fig. 9.
on p.382
383Fig. 10.
on p.383

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Appelman H. D., Coopersmith N. Pleomorphic spindle-cell carcinoma of the gallbladder. Relation to sarcoma of the gallbladder. Cancer. 1970 Mar;25(3):535–541. doi: 10.1002/1097-0142(197003)25:3<535::aid-cncr2820250307>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  2. Bloustein P. A. Association of carcinoma with congenital cystic conditions of the liver and bile ducts. Am J Gastroenterol. 1977 Jan;67(1):40–46. [PubMed] [Google Scholar]
  3. Bull P., Guzmán S., Nervi F. Mutagenic activity in stones from a patient with a congenital choledochal cyst. J Cancer Res Clin Oncol. 1984;107(1):61–63. doi: 10.1007/BF00395493. [DOI] [PubMed] [Google Scholar]
  4. Chaudhuri P. K., Chaudhuri B., Schuler J. J., Nyhus L. M. Carcinoma associated with congenital cystic dilation of bile ducts. Arch Surg. 1982 Oct;117(10):1349–1351. doi: 10.1001/archsurg.1982.01380340067016. [DOI] [PubMed] [Google Scholar]
  5. Dayton M. T., Longmire W. P., Jr, Tompkins R. K. Caroli's Disease: a premalignant condition? Am J Surg. 1983 Jan;145(1):41–48. doi: 10.1016/0002-9610(83)90164-2. [DOI] [PubMed] [Google Scholar]
  6. Deziel D. J., Rossi R. L., Munson J. L., Braasch J. W., Silverman M. L. Management of bile duct cysts in adults. Arch Surg. 1986 Apr;121(4):410–415. doi: 10.1001/archsurg.1986.01400040046006. [DOI] [PubMed] [Google Scholar]
  7. FORTNER J. G. An appraisal of the pathogenesis of primary carcinoma of the extrahepatic biliary tract. Surgery. 1958 Apr;43(4):563–571. [PubMed] [Google Scholar]
  8. Kagawa Y., Kashihara S., Kuramoto S., Maetani S. Carcinoma arising in a congenitally dilated biliary tract. Report of a case and review of the literature. Gastroenterology. 1978 Jun;74(6):1286–1294. [PubMed] [Google Scholar]
  9. Longmire W. P., Jr Tumors of the extrahepatic biliary radicals. Curr Probl Cancer. 1976 Aug;1(2):1–45. doi: 10.1016/s0147-0272(76)80006-2. [DOI] [PubMed] [Google Scholar]
  10. Miyano T., Suruga K., Chen S. C. A clinicopathologic study of choledochal cyst. World J Surg. 1980;4(2):231–238. doi: 10.1007/BF02393586. [DOI] [PubMed] [Google Scholar]
  11. Nagorney D. M., McIlrath D. C., Adson M. A. Choledochal cysts in adults: clinical management. Surgery. 1984 Oct;96(4):656–663. [PubMed] [Google Scholar]
  12. Ozawa K., Yamada T., Matumoto Y., Tobe R. Carcinoma arising in a choledochocele. Cancer. 1980 Jan 1;45(1):195–197. doi: 10.1002/1097-0142(19800101)45:1<195::aid-cncr2820450131>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  13. SOMMERS S. C., MEISSNER W. A. Unusual carcinomas of the pancreas. AMA Arch Pathol. 1954 Aug;58(2):101–111. [PubMed] [Google Scholar]
  14. Tanaka M., Ikeda S., Kawakami K., Nakayama F. The presence of a positive pressure gradient from pancreatic duct to choledochal cyst demonstrated by duodenoscopic microtransducer manometry: clue to pancreaticobiliary reflux. Endoscopy. 1982 Mar;14(2):45–47. doi: 10.1055/s-2007-1021574. [DOI] [PubMed] [Google Scholar]
  15. Todani T., Tabuchi K., Watanabe Y., Kobayashi T. Carcinoma arising in the wall of congenital bile duct cysts. Cancer. 1979 Sep;44(3):1134–1141. doi: 10.1002/1097-0142(197909)44:3<1134::aid-cncr2820440350>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  16. Todani T., Watanabe Y., Fujii T., Uemura S. Anomalous arrangement of the pancreatobiliary ductal system in patients with a choledochal cyst. Am J Surg. 1984 May;147(5):672–676. doi: 10.1016/0002-9610(84)90139-9. [DOI] [PubMed] [Google Scholar]
  17. Voyles C. R., Smadja C., Shands W. C., Blumgart L. H. Carcinoma in choledochal cysts. Age-related incidence. Arch Surg. 1983 Aug;118(8):986–988. doi: 10.1001/archsurg.1983.01390080088022. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES