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. 1987 Feb;205(2):199–202. doi: 10.1097/00000658-198702000-00016

Effect of a stable prostacyclin analogue on canine renal allograft rejection.

M Tobimatsu, Y Ueda, K Toyoda, S Saito, K Konomi
PMCID: PMC1492822  PMID: 3545109

Abstract

The effect of OP-41483 (Ono Pharmaceutical Co., Osaka, Japan), a stable prostacyclin analogue, on canine renal allograft rejection was investigated. Administration for 4 days after transplantation significantly increased renal cortical blood flow and urine output when compared with untreated dogs with renal allografts. Serum creatinine levels remained relatively low during postoperative days 1-4. Mean animal survival time was prolonged. Vascular lesions and mononuclear cell infiltration were greatly diminished in biopsy specimens removed on day 4. This stable prostacyclin analogue provided a degree of protection against canine renal allograft rejection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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