Skip to main content
NCBI home page
Annals of Surgery logoLink to Annals of Surgery
. 1988 Feb;207(2):195–200. doi: 10.1097/00000658-198802000-00014

The effect of hemorrhage and resuscitation on serum levels of immunoreactive atrial natriuretic factor.

S R Shackford 1, C H Norton 1, M G Ziegler 1, K D Wilner 1
PMCID: PMC1493366  PMID: 2963597

Abstract

To determine if atrial natriuretic factor (ANF) might have a role in blood volume regulation during hypovolemia, the serum level was measured before and after hemorrhage and resuscitation (RESUS) in a porcine shock model. Hemorrhage of 40% of the blood volume produced significant (p less than 0.01) decreases in mean arterial pressure, central venous pressure, and cardiac output and a significant increase in heart rate (HR), plasma renin activity, and catecholamines (p less than 0.01). Hemorrhage was also associated with a significant increase in ANF (p less than 0.05). All parameters except HR returned to baseline values with RESUS. The rise in ANF associated with moderate hemorrhage was unexpected, but may have been due to the profound tachycardia or decreased degradation during shock. Sodium excretion and urine flow increased significantly with RESUS without an associated increase in ANF, suggesting that ANF may not be involved in the early phase of postresuscitation diuresis.

Full text

PDF
195

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atlas S. A., Kleinert H. D., Camargo M. J., Januszewicz A., Sealey J. E., Laragh J. H., Schilling J. W., Lewicki J. A., Johnson L. K., Maack T. Purification, sequencing and synthesis of natriuretic and vasoactive rat atrial peptide. Nature. 1984 Jun 21;309(5970):717–719. doi: 10.1038/309717a0. [DOI] [PubMed] [Google Scholar]
  2. Boyd D. R., Addis H. M., Chilimindris C., Lowe R. J., Folk F. A., Baker R. J. Utilization of osmometry in critically ill surgical patients. Arch Surg. 1971 Apr;102(4):363–372. doi: 10.1001/archsurg.1971.01350040125025. [DOI] [PubMed] [Google Scholar]
  3. Burnett J. C., Jr, Kao P. C., Hu D. C., Heser D. W., Heublein D., Granger J. P., Opgenorth T. J., Reeder G. S. Atrial natriuretic peptide elevation in congestive heart failure in the human. Science. 1986 Mar 7;231(4742):1145–1147. doi: 10.1126/science.2935937. [DOI] [PubMed] [Google Scholar]
  4. Dietz J. R. Release of natriuretic factor from rat heart-lung preparation by atrial distension. Am J Physiol. 1984 Dec;247(6 Pt 2):R1093–R1096. doi: 10.1152/ajpregu.1984.247.6.R1093. [DOI] [PubMed] [Google Scholar]
  5. Dunn F. L., Brennan T. J., Nelson A. E., Robertson G. L. The role of blood osmolality and volume in regulating vasopressin secretion in the rat. J Clin Invest. 1973 Dec;52(12):3212–3219. doi: 10.1172/JCI107521. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Durrett L. R., Ziegler M. G. A sensitive radioenzymatic assay for catechol drugs. J Neurosci Res. 1980;5(6):587–598. doi: 10.1002/jnr.490050613. [DOI] [PubMed] [Google Scholar]
  7. Eskay R., Zukowska-Grojec Z., Haass M., Dave J. R., Zamir N. Circulating atrial natriuretic peptides in conscious rats: regulation of release by multiple factors. Science. 1986 May 2;232(4750):636–639. doi: 10.1126/science.2938258. [DOI] [PubMed] [Google Scholar]
  8. Ganz W., Swan H. J. Measurement of blood flow by thermodilution. Am J Cardiol. 1972 Feb;29(2):241–246. doi: 10.1016/0002-9149(72)90635-2. [DOI] [PubMed] [Google Scholar]
  9. Goetz K. L., Wang B. C., Geer P. G., Leadley R. J., Jr, Reinhardt H. W. Atrial stretch increases sodium excretion independently of release of atrial peptides. Am J Physiol. 1986 May;250(5 Pt 2):R946–R950. doi: 10.1152/ajpregu.1986.250.5.R946. [DOI] [PubMed] [Google Scholar]
  10. Gutkowska J., Bourassa M., Roy D., Thibault G., Garcia R., Cantin M., Genest J. Immunoreactive atrial natriuretic factor (IR-ANF) in human plasma. Biochem Biophys Res Commun. 1985 May 16;128(3):1350–1357. doi: 10.1016/0006-291x(85)91089-7. [DOI] [PubMed] [Google Scholar]
  11. Haber E., Koerner T., Page L. B., Kliman B., Purnode A. Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J Clin Endocrinol Metab. 1969 Oct;29(10):1349–1355. doi: 10.1210/jcem-29-10-1349. [DOI] [PubMed] [Google Scholar]
  12. Laragh J. H. Atrial natriuretic hormone, the renin-aldosterone axis, and blood pressure-electrolyte homeostasis. N Engl J Med. 1985 Nov 21;313(21):1330–1340. doi: 10.1056/NEJM198511213132106. [DOI] [PubMed] [Google Scholar]
  13. Le Quesne L. P., Cochrane J. P., Fieldman N. R. Fluid and electrolyte disturbances after trauma: the role of adrenocortical and pituitary hormones. Br Med Bull. 1985 Jul;41(3):212–217. doi: 10.1093/oxfordjournals.bmb.a072053. [DOI] [PubMed] [Google Scholar]
  14. Manning P. T., Schwartz D., Katsube N. C., Holmberg S. W., Needleman P. Vasopressin-stimulated release of atriopeptin: endocrine antagonists in fluid homeostasis. Science. 1985 Jul 26;229(4711):395–397. doi: 10.1126/science.2990050. [DOI] [PubMed] [Google Scholar]
  15. Napier M. A., Vandlen R. L., Albers-Schönberg G., Nutt R. F., Brady S., Lyle T., Winquist R., Faison E. P., Heinel L. A., Blaine E. H. Specific membrane receptors for atrial natriuretic factor in renal and vascular tissues. Proc Natl Acad Sci U S A. 1984 Oct;81(19):5946–5950. doi: 10.1073/pnas.81.19.5946. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Needleman P., Greenwald J. E. Atriopeptin: a cardiac hormone intimately involved in fluid, electrolyte, and blood-pressure homeostasis. N Engl J Med. 1986 Mar 27;314(13):828–834. doi: 10.1056/NEJM198603273141306. [DOI] [PubMed] [Google Scholar]
  17. Oshima T., Currie M. G., Geller D. M., Needleman P. An atrial peptide is a potent renal vasodilator substance. Circ Res. 1984 May;54(5):612–616. doi: 10.1161/01.res.54.5.612. [DOI] [PubMed] [Google Scholar]
  18. PETERS J. P. The problem of cardiac edema. Am J Med. 1952 Jan;12(1):66–76. doi: 10.1016/0002-9343(52)90170-8. [DOI] [PubMed] [Google Scholar]
  19. Rankin A. J., Courneya C. A., Wilson N., Ledsome J. R. Tachycardia releases atrial natriuretic peptide in the anesthetized rabbit. Life Sci. 1986 May 26;38(21):1951–1957. doi: 10.1016/0024-3205(86)90224-9. [DOI] [PubMed] [Google Scholar]
  20. Schafferhans K., Heidbreder E., Grimm D., Heidland A. Norepinephrine-induced acute renal failure: beneficial effects of atrial natriuretic factor. Nephron. 1986;44(3):240–244. doi: 10.1159/000183994. [DOI] [PubMed] [Google Scholar]
  21. Schiffrin E. L., Gutkowska J., Kuchel O., Cantin M., Genest J. Plasma concentration of atrial natriuretic factor in a patient with paroxysmal atrial tachycardia. N Engl J Med. 1985 May 2;312(18):1196–1197. doi: 10.1056/NEJM198505023121822. [DOI] [PubMed] [Google Scholar]
  22. Theron J. J., Biagio R., Meyer A. C., Boekkooi S. Ultrastructural observations on the maturation and secretion of granules in atrial myocardium. J Mol Cell Cardiol. 1978 Jun;10(6):567–572. doi: 10.1016/0022-2828(78)90014-7. [DOI] [PubMed] [Google Scholar]
  23. Traverso L. W., Moore C. C., Tillman F. J. A clinically applicable exsanguination shock model in swine. Circ Shock. 1984;12(1):1–7. [PubMed] [Google Scholar]
  24. de Bold A. J. Atrial natriuretic factor: a hormone produced by the heart. Science. 1985 Nov 15;230(4727):767–770. doi: 10.1126/science.2932797. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES