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. 1988 Jun;207(6):648–654. doi: 10.1097/00000658-198806000-00002

Intraoperative radiotherapy for patients with carcinoma of the pancreas. The Howard University Hospital experience, 1978-1986.

W B Tuckson 1, A L Goldson 1, E Ashayeri 1, M Halyard-Richardson 1, R L DeWitty 1, L D Leffall Jr 1
PMCID: PMC1493531  PMID: 3389933

Abstract

During the period from 1978 to 1986, 106 patients were diagnosed with carcinoma of the pancreas; 30 of these patients were excluded from this study. Of the remaining 76 patients, 40 did not receive intraoperative radiotherapy (IORT) and were used as the nonrandomized control group for the 36 patients who did receive IORT after histologic confirmation of carcinoma of the pancreas. The records of 35 patients were available for review. The group receiving IORT ranged in ages from 43 to 89 years (20 males and 15 females). Seventeen patients had distant metastatic disease. The primary was located in the head of the pancreas in 32 and the body in three. No patient in this group had a curative resection. All patients were treated by a combination of biliary and gastric bypass prior to or concurrent with IORT. IORT was begun only after obtaining a histologic diagnosis and prior to the completion of any anastomosis. Necrotizing pancreatitis occurred in the treated group. There was no statistically significant difference in the survival of the nonrandomized control and treated groups.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abe M., Shibamoto Y., Takahashi M., Manabe T., Tobe T., Inamoto T. Intraoperative radiotherapy in carcinoma of the stomach and pancreas. World J Surg. 1987 Aug;11(4):459–464. doi: 10.1007/BF01655810. [DOI] [PubMed] [Google Scholar]
  2. Abe M., Takahashi M. Intraoperative radiotherapy: the Japanese experience. Int J Radiat Oncol Biol Phys. 1981 Jul;7(7):863–868. doi: 10.1016/0360-3016(81)90001-8. [DOI] [PubMed] [Google Scholar]
  3. Arcangeli G., Benassi M., Cividalli A., Lovisolo G. A., Mauro F. Radiotherapy and hyperthermia. Analysis of clinical results and identification of prognostic variables. Cancer. 1987 Sep 1;60(5):950–956. doi: 10.1002/1097-0142(19870901)60:5<950::aid-cncr2820600506>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  4. Ashayeri E., Dallas T., Goldson A. L., Seton M., Conseption D. T., Manning J. C. Anesthesia in intraoperative radiotherapy patients. J Natl Med Assoc. 1986 Mar;78(3):193–199. [PMC free article] [PubMed] [Google Scholar]
  5. Ashayeri E., Halyard M., Goldson A. L., Cruz L., Nibhanupudy J. R., DeWitty R., Galal F., Marquis B., Slaughter L., Landes F. The first simultaneous intraoperative hyperthermia and radiotherapy procedure: dog experiment and technique. J Natl Med Assoc. 1987 Jun;79(6):619–624. [PMC free article] [PubMed] [Google Scholar]
  6. Dewhirst M. W., Sim D. A. Estimation of therapeutic gain in clinical trials involving hyperthermia and radiotherapy. Int J Hyperthermia. 1986 Apr-Jun;2(2):165–178. doi: 10.3109/02656738609012392. [DOI] [PubMed] [Google Scholar]
  7. Dobelbower R. R., Jr, Merrick H. W., 3rd, Ahuja R. K., Skeel R. T. 125I interstitial implant, precision high-dose external beam therapy, and 5-FU for unresectable adenocarcinoma of pancreas and extrahepatic biliary tree. Cancer. 1986 Nov 15;58(10):2185–2195. doi: 10.1002/1097-0142(19861115)58:10<2185::aid-cncr2820581004>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  8. Goldson A. L., Ashaveri E., Espinoza M. C., Roux V., Cornwell E., Rayford L., McLaren M., Nibhanupudy R., Mahan A., Taylor H. F. Single high dose intraoperative electrons for advanced stage pancreatic cancer: phase I pilot study. Int J Radiat Oncol Biol Phys. 1981 Jul;7(7):869–874. doi: 10.1016/0360-3016(81)90002-x. [DOI] [PubMed] [Google Scholar]
  9. Goldson A. L. Past, Present, and Prospects of intraoperative radiotherapy (IOR). Semin Oncol. 1981 Mar;8(1):59–64. [PubMed] [Google Scholar]
  10. Gunderson L. L., Martin J. K., Jr, Earle J. D., Byer D. E., Voss M., Fieck J. M., Kvols L. K., Rorie D. K., Martinez A., Nagorney D. M. Intraoperative and external beam irradiation with or without resection: Mayo pilot experience. Mayo Clin Proc. 1984 Oct;59(10):691–699. doi: 10.1016/s0025-6196(12)62058-8. [DOI] [PubMed] [Google Scholar]
  11. Gunderson L. L., Martin J. K., Kvols L. K., Nagorney D. M., Fieck J. M., Wieand H. S., Martinez A., O'Connell M. J., Earle J. D., McIlrath D. C. Intraoperative and external beam irradiation +/- 5-FU for locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys. 1987 Mar;13(3):319–329. doi: 10.1016/0360-3016(87)90005-8. [DOI] [PubMed] [Google Scholar]
  12. Rich T. A. Intraoperative radiotherapy. Radiother Oncol. 1986 Jul;6(3):207–221. doi: 10.1016/s0167-8140(86)80155-4. [DOI] [PubMed] [Google Scholar]
  13. Rich T. A. Radiation therapy for pancreatic cancer: eleven year experience at the JCRT. Int J Radiat Oncol Biol Phys. 1985 Apr;11(4):759–763. doi: 10.1016/0360-3016(85)90308-6. [DOI] [PubMed] [Google Scholar]
  14. Shipley W. U., Nardi G. L., Cohen A. M., Ling C. C. Iodine-125 implant and external beam irradiation in patients with localized pancreatic carcinoma: a comparative study to surgical resection. Cancer. 1980 Feb 15;45(4):709–714. doi: 10.1002/1097-0142(19800215)45:4<709::aid-cncr2820450416>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  15. Shipley W. U., Wood W. C., Tepper J. E., Warshaw A. L., Orlow E. L., Kaufman S. D., Battit G. E., Nardi G. L. Intraoperative electron beam irradiation for patients with unresectable pancreatic carcinoma. Ann Surg. 1984 Sep;200(3):289–296. doi: 10.1097/00000658-198409000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Sindelar W. F., Hoekstra H., Restrepo C., Kinsella T. J. Pathological tissue changes following intraoperative radiotherapy. Am J Clin Oncol. 1986 Dec;9(6):504–509. doi: 10.1097/00000421-198612000-00008. [DOI] [PubMed] [Google Scholar]
  17. Syed A. M., Puthawala A. A., Neblett D. L. Interstitial iodine-125 implant in the management of unresectable pancreatic carcinoma. Cancer. 1983 Sep 1;52(5):808–813. doi: 10.1002/1097-0142(19830901)52:5<808::aid-cncr2820520510>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  18. Tepper J. E., Shipley W. U., Warshaw A. L., Nardi G. L., Wood W. C., Orlow E. L. The role of misonidazole combined with intraoperative radiation therapy in the treatment of pancreatic carcinoma. J Clin Oncol. 1987 Apr;5(4):579–584. doi: 10.1200/JCO.1987.5.4.579. [DOI] [PubMed] [Google Scholar]
  19. Wood W. C., Shipley W. U., Gunderson L. L., Cohen A. M., Nardi G. L. Intraoperative irradiation for unresectable pancreatic carcinoma. Cancer. 1982 Mar 15;49(6):1272–1275. doi: 10.1002/1097-0142(19820315)49:6<1272::aid-cncr2820490632>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]

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