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. 1988 Jul;208(1):65–70. doi: 10.1097/00000658-198807000-00009

Effects of a stable prostacyclin analog on experimental ischemic acute renal failure.

M Tobimatsu 1, Y Ueda 1, S Saito 1, T Tsumagari 1, K Konomi 1
PMCID: PMC1493582  PMID: 3291800

Abstract

The effect of OP-41483, a stable prostacyclin (PGI2) analog, on ischemic acute renal failure (ARF) was investigated in dogs. Administration of OP-41483 for three days after ischemia significantly increased renal cortical blood flow (RCBF) when compared with dogs treated with the saline vehicle. In the OP-41483-treated group, serum creatinine levels remained relatively low during postoperative days 1-3 and mean survival time was prolonged. Injection of a silicone rubber vascular casting compound (Microfil) revealed increased numbers of visible renal cortical glomeruli and microvessels compared to the saline vehicle group. Histologic sections showed only very limited tubular necrosis, whereas sections of kidneys treated with saline showed extensive tubular necrosis. In conclusion, this stable prostacyclin analog provided a significant degree of protection for the kidneys from ischemic injury and may be useful in a clinical setting.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AUKLAND K., BOWER B. F., BERLINER R. W. MEASUREMENT OF LOCAL BLOOD FLOW WITH HYDROGEN GAS. Circ Res. 1964 Feb;14:164–187. doi: 10.1161/01.res.14.2.164. [DOI] [PubMed] [Google Scholar]
  2. Adaikan P. G., Kottegoda S. R., Lau L. C., Tai M. Y., Karim S. M. Inhibition of platelet aggregation and reversal of vasopressin-induced ECG changes by a carboprostacyclin analogue, ONO 41483, in primates. Prostaglandins Leukot Med. 1982 Sep;9(3):307–320. doi: 10.1016/s0262-1746(82)80018-8. [DOI] [PubMed] [Google Scholar]
  3. Autor A. P., Bonham A. C., Thies R. L. Toxicity of oxygen radicals in cultured pulmonary endothelial cells. J Toxicol Environ Health. 1984;13(2-3):387–395. doi: 10.1080/15287398409530505. [DOI] [PubMed] [Google Scholar]
  4. Baker G. L., Corry R. J., Autor A. P. Oxygen free radical induced damage in kidneys subjected to warm ischemia and reperfusion. Protective effect of superoxide dismutase. Ann Surg. 1985 Nov;202(5):628–641. doi: 10.1097/00000658-198511000-00016. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Casey K. F., Machiedo G. W., Lyons M. J., Slotman G. J., Novak R. T. Alteration of postischemic renal pathology by prostaglandin infusion. J Surg Res. 1980 Jul;29(1):1–10. doi: 10.1016/0022-4804(80)90002-5. [DOI] [PubMed] [Google Scholar]
  6. Chaudhari A., Kirschenbaum M. A. Altered glomerular eicosanoid biosynthesis in uranyl nitrate-induced acute renal failure. Biochim Biophys Acta. 1984 Feb 9;792(2):135–140. doi: 10.1016/0005-2760(84)90214-5. [DOI] [PubMed] [Google Scholar]
  7. Ferreri N. R., McGiff J. C., Miller M. J., Schwartzman M., Spokas E. G., Wong P. Y. The kidney and arachidonic acid metabolism. Adv Prostaglandin Thromboxane Leukot Res. 1983;11:481–485. [PubMed] [Google Scholar]
  8. Frega N. S., DiBona D. R., Guertler B., Leaf A. Ischemic renal injury. Kidney Int Suppl. 1976 Oct;6:S17–S25. [PubMed] [Google Scholar]
  9. Gryglewski R. J., Bunting S., Moncada S., Flower R. J., Vane J. R. Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides. Prostaglandins. 1976 Nov;12(5):685–713. doi: 10.1016/0090-6980(76)90047-2. [DOI] [PubMed] [Google Scholar]
  10. Hollenberg N. K., Epstein M., Rosen S. M., Basch R. I., Oken D. E., Merrill J. P. Acute oliguric renal failure in man: evidence for preferential renal cortical ischemia. Medicine (Baltimore) 1968 Nov;47(6):455–474. doi: 10.1097/00005792-196811000-00001. [DOI] [PubMed] [Google Scholar]
  11. KETY S. S. The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev. 1951 Mar;3(1):1–41. [PubMed] [Google Scholar]
  12. Kaufman R. P., Jr, Anner H., Kobzik L., Valeri C. R., Shepro D., Hechtman H. B. Vasodilator prostaglandins (PG) prevent renal damage after ischemia. Ann Surg. 1987 Feb;205(2):195–198. doi: 10.1097/00000658-198702000-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lelcuk S., Alexander F., Kobzik L., Valeri C. R., Shepro D., Hechtman H. B. Prostacyclin and thromboxane A2 moderate postischemic renal failure. Surgery. 1985 Aug;98(2):207–212. [PubMed] [Google Scholar]
  14. Lifschitz M. D., Barnes J. L. Prostaglandin I2 attenuates ischemic acute renal failure in the rat. Am J Physiol. 1984 Nov;247(5 Pt 2):F714–F717. doi: 10.1152/ajprenal.1984.247.5.F714. [DOI] [PubMed] [Google Scholar]
  15. Moncada S., Gryglewski R. J., Bunting S., Vane J. R. A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation. Prostaglandins. 1976 Nov;12(5):715–737. doi: 10.1016/0090-6980(76)90048-4. [DOI] [PubMed] [Google Scholar]
  16. Moncada S., Vane J. R. Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin. Pharmacol Rev. 1978 Sep;30(3):293–331. [PubMed] [Google Scholar]
  17. Neumayer H. H., Wagner K., Preuschof L., Stanke H., Schultze G., Molzahn M. Amelioration of postischemic acute renal failure by prostacyclin analogue (iloprost): long-term studies with chronically instrumented conscious dogs. J Cardiovasc Pharmacol. 1986 Jul-Aug;8(4):785–790. [PubMed] [Google Scholar]
  18. Oken D. E., DiBona G. F., McDonald F. D. Micropuncture studies of the recovery phase of myohemoglobinuric acute renal failure in the rat. J Clin Invest. 1970 Apr;49(4):730–737. doi: 10.1172/JCI106285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Ota K., Kawaguchi H., Takahashi K., Ito K. A new prostacyclin analogue - an anticoagulant applicable to hemodialysis. Trans Am Soc Artif Intern Organs. 1983;29:419–424. [PubMed] [Google Scholar]

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