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. 1988 Oct;208(4):524–531. doi: 10.1097/00000658-198810000-00014

Insulin and acivicin improve host nutrition and prevent tumor growth during total parenteral nutrition.

W T Chance 1, L Cao 1, J E Fischer 1
PMCID: PMC1493740  PMID: 3140745

Abstract

The effect that a 14-day treatment program of total parenteral nutrition (TPN) combined with the glutamine antimetabolite, acivicin, and anabolic hormone, insulin, has on carcass weight and muscle sparing was investigated in tumor-bearing rats. Although TPN resulted in increased carcass weight gain as compared to chow-fed tumor-bearing rats, no savings in gastrocnemius muscle could be demonstrated. The combination of TPN with daily insulin treatment elicited significant increases in both carcass weight and muscle savings, with no alteration in tumor growth. Although combining acivicin with TPN halted tumor growth and increased carcass weight, the change in carcass weight was less than that observed with the insulin-TPN combination. No muscle savings were observed in the acivicin-TPN-treated rats. Yet when acivicin and insulin were combined with TPN, tumor growth was stopped, carcass weight was gained, and muscle mass was saved. Therefore, these experiments suggest that it is possible to add lean body tissue and stabilize tumor growth in rats that receive TPN through anabolic hormone treatment combined with an inhibitor of tumor metabolism.

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Selected References

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  1. Adolphson C. C., Ajani J. A., Stroehlein J. R., Barlogie B., Bodey G. P., Korinek J., Bedikian A. Y. Phase II trial of acivicin in patients with advanced colorectal carcinoma. Am J Clin Oncol. 1986 Jun;9(3):189–191. doi: 10.1097/00000421-198606000-00003. [DOI] [PubMed] [Google Scholar]
  2. Baron P. L., Lawrence W., Jr, Chan W. M., White F. K., Banks W. L., Jr Effects of parenteral nutrition on cell cycle kinetics of head and neck cancer. Arch Surg. 1986 Nov;121(11):1282–1286. doi: 10.1001/archsurg.121.11.1282. [DOI] [PubMed] [Google Scholar]
  3. Bozzetti F., Ammatuna M., Migliavacca S., Bonalumi M. G., Facchetti G., Pupa A., Terno G. Total parenteral nutrition prevents further nutritional deterioration in patients with cancer cachexia. Ann Surg. 1987 Feb;205(2):138–143. doi: 10.1097/00000658-198702000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Burt M. E., Gorschboth C. M., Brennan M. F. A controlled, prospective, randomized trial evaluating the metabolic effects of enteral and parenteral nutrition in the cancer patient. Cancer. 1982 Mar 15;49(6):1092–1105. doi: 10.1002/1097-0142(19820315)49:6<1092::aid-cncr2820490606>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  5. Burt M. E., Stein T. P., Schwade J. G., Brennan M. F. Whole-body protein metabolism in cancer-bearing patients. Effect of total parenteral nutrition and associated serum insulin response. Cancer. 1984 Mar 15;53(6):1246–1252. doi: 10.1002/1097-0142(19840315)53:6<1246::aid-cncr2820530605>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  6. Cameron I. L., Pavlat W. A. Stimulation of growth of a transplantable hepatoma in rats by parenteral nutrition. J Natl Cancer Inst. 1976 Mar;56(3):597–602. doi: 10.1093/jnci/56.3.597. [DOI] [PubMed] [Google Scholar]
  7. Chance W. T., Cao L., Kim M. W., Nelson J. L., Fischer J. E. Reduction of tumor growth following treatment with a glutamine antimetabolite. Life Sci. 1988;42(1):87–94. doi: 10.1016/0024-3205(88)90627-3. [DOI] [PubMed] [Google Scholar]
  8. Chance W. T., Cao L., Nelson J. L., Foley-Nelson T., Fischer J. E. Acivicin reduces tumor growth during total parenteral nutrition (TPN). Surgery. 1987 Aug;102(2):386–394. [PubMed] [Google Scholar]
  9. Chance W. T., Muggia-Sullam M., Chen M. H., Murphy R. F., Fischer J. E. Reversal of tumor-induced biochemical abnormalities by insulin treatment in rats. J Natl Cancer Inst. 1986 Aug;77(2):497–503. [PubMed] [Google Scholar]
  10. Chance W. T., van Lammeren F. M., Chen M. H., Chen W. J., Murphy R. F., Joffe S. N., Fischer J. E. Plasma and brain cholecystokinin levels in cancer anorexia. J Surg Res. 1984 May;36(5):490–498. doi: 10.1016/0022-4804(84)90131-8. [DOI] [PubMed] [Google Scholar]
  11. Evans W. K., Makuch R., Clamon G. H., Feld R., Weiner R. S., Moran E., Blum R., Shepherd F. A., Jeejeebhoy K. N., DeWys W. D. Limited impact of total parenteral nutrition on nutritional status during treatment for small cell lung cancer. Cancer Res. 1985 Jul;45(7):3347–3353. [PubMed] [Google Scholar]
  12. Fischer J. E. Adjuvant parenteral nutrition in the patient with cancer. Surgery. 1984 Sep;96(3):578–580. [PubMed] [Google Scholar]
  13. Hartree E. F. Determination of protein: a modification of the Lowry method that gives a linear photometric response. Anal Biochem. 1972 Aug;48(2):422–427. doi: 10.1016/0003-2697(72)90094-2. [DOI] [PubMed] [Google Scholar]
  14. Karlberg H. I., Fischer J. E. Hyperalimentation in cancer. West J Med. 1982 May;136(5):390–397. [PMC free article] [PubMed] [Google Scholar]
  15. Klein S., Simes J., Blackburn G. L. Total parenteral nutrition and cancer clinical trials. Cancer. 1986 Sep 15;58(6):1378–1386. doi: 10.1002/1097-0142(19860915)58:6<1378::aid-cncr2820580635>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  16. Koretz R. L. Parental nutrition: is it oncologically logical? J Clin Oncol. 1984 May;2(5):534–538. doi: 10.1200/JCO.1984.2.5.534. [DOI] [PubMed] [Google Scholar]
  17. Manchester K. L. Effect of insulin on protein synthesis. Diabetes. 1972;21(2 Suppl):447–452. doi: 10.2337/diab.21.2.s447. [DOI] [PubMed] [Google Scholar]
  18. Moley J. F., Morrison S. D., Norton J. A. Insulin reversal of cancer cachexia in rats. Cancer Res. 1985 Oct;45(10):4925–4931. [PubMed] [Google Scholar]
  19. Mullen J. L., Buzby G. P., Matthews D. C., Smale B. F., Rosato E. F. Reduction of operative morbidity and mortality by combined preoperative and postoperative nutritional support. Ann Surg. 1980 Nov;192(5):604–613. doi: 10.1097/00000658-198019250-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Müller J. M., Brenner U., Dienst C., Pichlmaier H. Preoperative parenteral feeding in patients with gastrointestinal carcinoma. Lancet. 1982 Jan 9;1(8263):68–71. doi: 10.1016/s0140-6736(82)90212-4. [DOI] [PubMed] [Google Scholar]
  21. Nixon D. W., Moffitt S., Lawson D. H., Ansley J., Lynn M. J., Kutner M. H., Heymsfield S. B., Wesley M., Chawla R., Rudman D. Total parenteral nutrition as an adjunct to chemotherapy of metastatic colorectal cancer. Cancer Treat Rep. 1981;65 (Suppl 5):121–128. [PubMed] [Google Scholar]
  22. O'Dwyer P. J., Alonso M. T., Leyland-Jones B. Acivicin: a new glutamine antagonist in clinical trials. J Clin Oncol. 1984 Sep;2(9):1064–1071. doi: 10.1200/JCO.1984.2.9.1064. [DOI] [PubMed] [Google Scholar]
  23. Popp M. B., Morrison S. D., Brennan M. F. Total parenteral nutrition in a methylcholanthrene-induced rat sarcoma model. Cancer Treat Rep. 1981;65 (Suppl 5):137–143. [PubMed] [Google Scholar]
  24. Popp M. B., Wagner S. C., Brito O. J. Host and tumor responses to increasing levels of intravenous nutritional support. Surgery. 1983 Aug;94(2):300–308. [PubMed] [Google Scholar]
  25. Schein P. S., Kisner D., Haller D., Blecher M., Hamosh M. Cachexia of malignancy: potential role of insulin in nutritional management. Cancer. 1979 May;43(5 Suppl):2070–2076. doi: 10.1002/1097-0142(197905)43:5+<2070::aid-cncr2820430715>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  26. Shamberger R. C., Brennan M. F., Goodgame J. T., Jr, Lowry S. F., Maher M. M., Wesley R. A., Pizzo P. A. A prospective, randomized study of adjuvant parenteral nutrition in the treatment of sarcomas: results of metabolic and survival studies. Surgery. 1984 Jul;96(1):1–13. [PubMed] [Google Scholar]
  27. Torosian M. H., Daly J. M. Nutritional support in the cancer-bearing host. Effects on host and tumor. Cancer. 1986 Oct 15;58(8 Suppl):1915–1929. doi: 10.1002/1097-0142(19861015)58:8+<1915::aid-cncr2820581421>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]

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