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. 1989 Mar;209(3):334–340. doi: 10.1097/00000658-198903000-00014

A new model for studying nutrition in peritonitis. The adverse effect of overfeeding.

J W Alexander 1, S J Gonce 1, P W Miskell 1, M D Peck 1, H Sax 1
PMCID: PMC1493937  PMID: 2493777

Abstract

In guinea pigs fed ad libitum, controlled intraperitoneal infusion of bacteria by an implanted 7-day osmotic pump resulted in peritonitis or abscess formation with a 50% survival 14-18 days after pump implantation. Administration of 125 kcal/kg/day of a diet found to be optimal for burned guinea pigs by continuous pump controlled feedings via a previously placed gastrostomy was well-tolerated, with a 62.5% mortality by Day 17. Administration of only 100 kcal/kg/day caused weight loss of approximately 17% after 16 days, but fewer animals died (42.8%, p = NS). Feeding either 150 kcal/kg/day or 175 kcal/kg/day caused death in all 25 animals (p less than 0.001) and their survival time was slightly shortened (p = NS) when compared with animals receiving 100 or 125 kcal/kg/day. This is the first animal model of peritonitis that permits incisive dissection of the relative influences of dietary composition on outcome, because survival can be extended to 2 weeks or more in the presence of continuing sepsis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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