Abstract
The turnover of I131-labelled IgG has been studied in cattle with mild hypoimmunoglobulinemia secondary to gastrointestinal disorders. A gastrointestinal loss of immunoglobulin was the most likely cause of the hypoimmunoglobulinemic condition. Thus, 6 animals with severe digestive symptoms (diarrhoea) had increased turnover rates of I131-IgG, whereas animals that had recovered from diarrhoeal diseases had normal or even low turnover rates (table I). It is concluded that the pattern of immunoglobulin metabolism is closely related to the clinical picture of the digestive disease.
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Selected References
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- JEFFRIES G. H., HOLMAN H. R., SLEISENGER M. H. Plasma proteins and the gastrointestinal tract. N Engl J Med. 1962 Mar 29;266:652–660. doi: 10.1056/NEJM196203292661307. [DOI] [PubMed] [Google Scholar]
- McFARLANE A. S. Efficient trace-labelling of proteins with iodine. Nature. 1958 Jul 5;182(4627):53–53. doi: 10.1038/182053a0. [DOI] [PubMed] [Google Scholar]
- Nansen P., Nielsen K. Metabolism of bovine immunoglobulin. I. Metabolism of bovine IgG in cattle with chronic pyogenic infections. Can J Comp Med Vet Sci. 1966 Dec;30(12):327–331. [PMC free article] [PubMed] [Google Scholar]
- Nielsen K. Metabolism and distribution of I131-labelled albumin in pigs with gastrointestinal disease. Acta Vet Scand. 1966;7(4):321–329. doi: 10.1186/BF03547121. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WALDMANN T. A., SCHWAB P. J. IGG (7 S GAMMA GLOBULIN) METABOLISM IN HYPOGAMMAGLOBULINEMIA: STUDIES IN PATIENTS WITH DEFECTIVE GAMMA GLOBULIN SYNTHESIS, GASTROINTESTINAL PROTEIN LOSS, OR BOTH. J Clin Invest. 1965 Sep;44:1523–1533. doi: 10.1172/JCI105259. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WALDMANN T. A., STEINFELD J. L., DUTCHER T. F., DAVIDSON J. D., GORDON R. S., Jr The role of the gastrointestinal system in "idiopathic hypoproteinemia". Gastroenterology. 1961 Sep;41:197–207. [PubMed] [Google Scholar]
- WETTERFORS J., LILJEDAHL S. O., PLANTIN L. O., BIRKE G. HYPOALBUMINAEMIA IN ULCERATIVE COLITIS AND CERTAIN FORMS OF ENTERITIS. CLINICAL AND PATHOPHYSIOLOGICAL ASPECTS. Acta Med Scand. 1963 Nov;174:529–549. doi: 10.1111/j.0954-6820.1963.tb07953.x. [DOI] [PubMed] [Google Scholar]