Abstract
The virus of transmissible gastroenteritis produced sprue-like lesions in the small intestines of young pigs. These lesions were characterized by villous shortening, fusing and blunting in the jejunum and ileum. There was decreased height of the brush border and morphologic alteration of the villous epithelial cells from simple columnar to a variable cuboidal type. Accompanying these microscopic lesions were histochemical changes characterized by decreased staining intensity of acid phosphatase, alkaline phosphatase, adenosine triphosphatase, leucine aminopeptidase, succinic dehydrogenase and malic dehydrogenase in the affected intestinal mucosa. The clinical nature of transmissible gastroenteritis in the pig together with the histopathologic and histochemical changes may provide a useful experimental model for obtaining additional basic information on enteric disturbances.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BAY W. W., DOYLE L. P., HUTCHINGS L. M. The pathology and symptomatology of transmissible gastroenteritis. Am J Vet Res. 1951 Jul;12(44):215–218. [PubMed] [Google Scholar]
- Bustad L. K. Pigs in the laboratory. Sci Am. 1966 Jun;214(6):94–100. doi: 10.1038/scientificamerican0666-94. [DOI] [PubMed] [Google Scholar]
- HANDFORTH C. P., SORGER K. Failure of regeneration of small bowel mucosa following epidemic infantile gastroenteritis. Can Med Assoc J. 1961 Feb 25;84:425–427. [PMC free article] [PubMed] [Google Scholar]
- HESS R., SCARPELLI D. G., PEARSE A. G. The cytochemical localization of oxidative enzymes. II. Pyridine nucleotide-linked dehydrogenases. J Biophys Biochem Cytol. 1958 Nov 25;4(6):753–760. doi: 10.1083/jcb.4.6.753. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hooper B. E., Haelterman E. O. Growth of transmissible gastroenteritis virus in young pigs. Am J Vet Res. 1966 Jan;27(116):286–291. [PubMed] [Google Scholar]
- MILLER E. R., ULLREY D. E., ZUTAUT C. L., BALTZER B. V., SCHMIDT D. A., VINCENT B. H., HOEFER J. A., LUECKE R. W. VITAMIN D2 REQUIREMENT OF THE BABY PIG. J Nutr. 1964 Jun;83:140–148. doi: 10.1093/jn/83.2.140. [DOI] [PubMed] [Google Scholar]
- NACHLAS M. M., CRAWFORD D. T., SELIGMAN A. M. The histochemical demonstration of leucine aminopeptidase. J Histochem Cytochem. 1957 May;5(3):264–278. doi: 10.1177/5.3.264. [DOI] [PubMed] [Google Scholar]
- NACHLAS M. M., TSOU K. C., DE SOUZA E., CHENG C. S., SELIGMAN A. M. Cytochemical demonstration of succinic dehydrogenase by the use of a new p-nitrophenyl substituted ditetrazole. J Histochem Cytochem. 1957 Jul;5(4):420–436. doi: 10.1177/5.4.420. [DOI] [PubMed] [Google Scholar]
- PADYKULA H. A., HERMAN E. Factors affecting the activity of adenosine triphosphatase and other phosphatases as measured by histochemical techniques. J Histochem Cytochem. 1955 May;3(3):161–169. doi: 10.1177/3.3.161. [DOI] [PubMed] [Google Scholar]
- REBER E. F., WHITEHAIR C. K. The effect of transmissible gastroenteritis on the metabolism of baby pigs. Am J Vet Res. 1955 Jan;16(58):116–119. [PubMed] [Google Scholar]
- Rubin C. E., Dobbins W. O., 3rd Peroral biopsy of the small intestine. A review of its diagnostic usefulness. Gastroenterology. 1965 Dec;49(6):676–697. [PubMed] [Google Scholar]
- SPRINZ H., KUNDEL D. W., DAMMIN G. J., HOROWITZ R. E., SCHNEIDER H., FORMAL S. B. The response of the germfree guinea pig to oral bacterial challenge with Escherichia coli and Shigella flexneri. Am J Pathol. 1961 Dec;39:681–695. [PMC free article] [PubMed] [Google Scholar]
- Schenk E. A., Samloff I. M., Klipstein F. A. Morphologic characteristics of jejunal biopsy in celiac disease and tropical sprue. Am J Pathol. 1965 Nov;47(5):765–781. [PMC free article] [PubMed] [Google Scholar]
- Trapp A. L., Sanger V. L., Stalnaker E. Lesions of the small intestinal mucosa in transmissible gastroenteritis-infected germfree pigs. Am J Vet Res. 1966 Nov;27(121):1695–1702. [PubMed] [Google Scholar]