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. 1982 Jan 30;284(6312):299–302. doi: 10.1136/bmj.284.6312.299

Effects of alcohol and smoking on blood lead in middle-aged British men.

A G Shaper, S J Pocock, M Walker, C J Wale, B Clayton, H T Delves, L Hinks
PMCID: PMC1495866  PMID: 6800438

Abstract

A survey of middle-aged men in 24 British towns showed a strong association between blood lead concentrations, alcohol consumption, and cigarette smoking. The association with alcohol persisted after age, social class, body mass index, cigarette smoking, water lead concentrations, and the town of residence had been taken into account. There was an independent but less pronounced association between cigarette smoking and blood lead concentrations after adjustment for the other factors. The possible mechanisms include a decreased excretion of lead due to alcohol-induced hepatic dysfunction and an increased lead intake from cigarette smoking. These findings have implications for widespread measurement of blood lead concentrations in adults in the community and for all studies attempting to relate blood lead concentrations to environmental exposure.

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Selected References

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  1. Beevers D. G., Erskine E., Robertson M., Beattie A. D., Campbell B. C., Goldberg A., Moore M. R., Hawthorne V. M. Blood-lead and hypertension. Lancet. 1976 Jul 3;2(7975):1–3. [PubMed] [Google Scholar]
  2. Campbell B. C., Beattie A. D., Moore M. R., Goldberg A., Reid A. G. Renal insufficiency associated with excessive lead exposure. Br Med J. 1977 Feb 19;1(6059):482–485. doi: 10.1136/bmj.1.6059.482. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Castellino N., Lamanna P., Grieco B. Biliary excretion of lead in the rat. Br J Ind Med. 1966 Jul;23(3):237–239. doi: 10.1136/oem.23.3.237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cikrt M. Biliary excretion of 203 Hg, 64 Cu, 52 Mn, and 210 Pb in the rat. Br J Ind Med. 1972;29(1):74–80. [PMC free article] [PubMed] [Google Scholar]
  5. Delves H. T. A micro-sampling method for the rapid determination of lead in blood by atomic-absorption spectrophotometry. Analyst. 1970 May;95(130):431–438. doi: 10.1039/an9709500431. [DOI] [PubMed] [Google Scholar]
  6. Flindt M. L., King E., Walsh D. B. Blood lead and erythrocyte delta-aminolevulinic acid dehydratase levels in Manchester taxi drivers. Br J Ind Med. 1976 May;33(2):79–84. doi: 10.1136/oem.33.2.79. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gloag D. Sources of lead pollution. Br Med J (Clin Res Ed) 1981 Jan 3;282(6257):41–44. doi: 10.1136/bmj.282.6257.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Grandjean P., Olsen N. B., Hollnagel H. Influence of smoking and alcohol consumption on blood lead levels. Int Arch Occup Environ Health. 1981;48(4):391–397. doi: 10.1007/BF00378687. [DOI] [PubMed] [Google Scholar]
  9. Magid E., Hilden M. Elevated levels of blood lead in alcoholic liver disease. Int Arch Occup Environ Health. 1975 Jul 11;35(1):61–65. doi: 10.1007/BF01266326. [DOI] [PubMed] [Google Scholar]
  10. Mahaffey K. R., Goyer R. A., Wilson M. H. Influence of ethanol ingestion on lead toxicity in rats fed isocaloric diets. Arch Environ Health. 1974 Apr;28(4):217–222. doi: 10.1080/00039896.1974.10666471. [DOI] [PubMed] [Google Scholar]
  11. Moore M. R., Meredith P. A., Campbell B. C., Goldberg A., Pocock S. J. [Contribution of lead in drinking water to blood-lead]. Lancet. 1977 Sep 24;2(8039):661–662. doi: 10.1016/s0140-6736(77)92528-4. [DOI] [PubMed] [Google Scholar]
  12. Needleman H. L., Gunnoe C., Leviton A., Reed R., Peresie H., Maher C., Barrett P. Deficits in psychologic and classroom performance of children with elevated dentine lead levels. N Engl J Med. 1979 Mar 29;300(13):689–695. doi: 10.1056/NEJM197903293001301. [DOI] [PubMed] [Google Scholar]
  13. Pocock S. J. Factors influencing household water lead: a British national survey. Arch Environ Health. 1980 Jan-Feb;35(1):45–51. [PubMed] [Google Scholar]
  14. Pocock S. J., Shaper A. G., Cook D. G., Packham R. F., Lacey R. F., Powell P., Russell P. F. British Regional Heart Study: geographic variations in cardiovascular mortality, and the role of water quality. Br Med J. 1980 May 24;280(6226):1243–1249. doi: 10.1136/bmj.280.6226.1243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Shaper A. G., Pocock S. J., Walker M., Cohen N. M., Wale C. J., Thomson A. G. British Regional Heart Study: cardiovascular risk factors in middle-aged men in 24 towns. Br Med J (Clin Res Ed) 1981 Jul 18;283(6285):179–186. doi: 10.1136/bmj.283.6285.179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Sillett R. W., Wilson M. B., Malcolm R. E., Ball K. P. Deception among smokers. Br Med J. 1978 Oct 28;2(6146):1185–1186. doi: 10.1136/bmj.2.6146.1185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Thomas H. F., Elwood P. C., Toothill C., Morton M. Blood and water lead in a hard water area. Lancet. 1981 May 9;1(8228):1047–1048. doi: 10.1016/s0140-6736(81)92204-2. [DOI] [PubMed] [Google Scholar]
  18. Tola S., Nordman C. H. Smoking and blood lead concentrations in lead-exposed workers and an unexposed population. Environ Res. 1977 Apr;13(2):250–255. doi: 10.1016/0013-9351(77)90101-3. [DOI] [PubMed] [Google Scholar]
  19. Vives J. F., Bellet H., Lapinski H., Mirouze D., Richard J. L., Hirsch J. L., Soulayrac M., Mathieu-Daude P., Vallat G., Michel H. Alcoolisme chronique et intoxication saturnine. Gastroenterol Clin Biol. 1980 Feb;4(2):119–122. [PubMed] [Google Scholar]
  20. Yule Q., Lansdown R., Millar I. B., Urbanowicz M. A. The relationship between blood lead concentrations, intelligence and attainment in a school population: a pilot study. Dev Med Child Neurol. 1981 Oct;23(5):567–576. doi: 10.1111/j.1469-8749.1981.tb02038.x. [DOI] [PubMed] [Google Scholar]

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