Abstract
An analysis has been made of indications for amniocentesis in the Edinburgh area from 1979 to 1981. About 5% of all mothers underwent the procedure. Among 2137 amniocenteses, 37% were performed on mothers 35 years old or more, and 30% on patients with raised serum alpha-fetoprotein. The total number of amniocenteses and the categories have been stable for the past three years. As a result of amniocentesis 104 pregnancies were terminated, 66 of which (63%) followed a raised maternal serum alpha-fetoprotein indication, while only 10 (9.6%) were in mothers aged 35 or more. There were a further 12 terminations based on raised serum alpha-fetoprotein but where no amniocentesis had been thought necessary. Even when figures for anencephaly are excluded from the analysis, maternal serum alpha-fetoprotein screening was responsible for detecting 35 out of 63 (56%) abnormal fetuses. This constitutes a strong case for the continuation of alpha-fetoprotein screening programmes.
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Selected References
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- Brock D. J., Barron L., Duncan P., Scrimgeour J. B., Watt M. Significance of elevated mid-trimester maternal plasma-alpha-fetoprotein values. Lancet. 1979 Jun 16;1(8129):1281–1282. doi: 10.1016/s0140-6736(79)92238-4. [DOI] [PubMed] [Google Scholar]
- Brock D. J., Scrimgeour J. B., Steven J., Barron L., Watt M. Maternal plasma alpha-fetoprotein screening for fetal neural tube defects. Br J Obstet Gynaecol. 1978 Aug;85(8):575–581. doi: 10.1111/j.1471-0528.1978.tb14923.x. [DOI] [PubMed] [Google Scholar]
- Fearn J., Hibbard B. M., Laurence K. M., Roberts A., Robinson J. O. Screening for neural-tube defects and maternal anxiety. Br J Obstet Gynaecol. 1982 Mar;89(3):218–221. doi: 10.1111/j.1471-0528.1982.tb03618.x. [DOI] [PubMed] [Google Scholar]
- Harris R., Read A. P. New uncertainties in prenatal screening for neural tube defect. Br Med J (Clin Res Ed) 1981 May 2;282(6274):1416–1418. doi: 10.1136/bmj.282.6274.1416-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Holmes L. B. Genetic counseling for the older pregnant woman: new data and questions. N Engl J Med. 1978 Jun 22;298(25):1419–1421. doi: 10.1056/NEJM197806222982511. [DOI] [PubMed] [Google Scholar]
- Owens J. R., Harris F., McAllister E., West L. 19-year incidence of neural tube defects in area under constant surveillance. Lancet. 1981 Nov 7;2(8254):1032–1035. doi: 10.1016/s0140-6736(81)91226-5. [DOI] [PubMed] [Google Scholar]
- Smith I. W., Maitland N. J., Peutherer J. F., Robertson D. H. Restriction enzyme analysis of herpesvirus-2 DNA. Lancet. 1981 Dec 19;2(8260-61):1424–1424. doi: 10.1016/s0140-6736(81)92840-3. [DOI] [PubMed] [Google Scholar]
- Standing S. J., Brindle M. J., Macdonald A. P., Lacey R. W. Maternal alpha-fetoprotein screening: two years' experience in a low-risk district. Br Med J (Clin Res Ed) 1981 Sep 12;283(6293):705–707. doi: 10.1136/bmj.283.6293.705. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vitamin supplementation and neural tube defects. Lancet. 1982 Jan 30;1(8266):275–276. [PubMed] [Google Scholar]