Abstract
Drug histories were obtained from 76 patients at the time of initial Eder-Puestow dilatation for benign oesophageal stricture. Six patients had consumed drugs known to cause oesophageal ulceration (emepronium bromide and potassium preparations). Of the remaining 70 patients, 22 had regularly taken a non-steroidal anti-inflammatory drug before the onset of dysphagia compared with 10 patients in a control group matched for age and sex; this difference was significant (p less than 0.02). Non-steroidal anti-inflammatory drugs may have a causative role in the formation of oesophageal stricture in patients with gastro-oesophageal reflux, in whom they should be prescribed with caution.
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Selected References
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- Agdal N. Medicininducerede esophagusskader. En oversigt samt et tilfaelde af indometacinfremkaldt ulceration med dødelig udgang. Ugeskr Laeger. 1979 Oct 29;141(44):3019–3021. [PubMed] [Google Scholar]
- Carlborg B., Kumlien A., Olsson H. Medikamentella esofagusstrikturer. Lakartidningen. 1978 Dec 6;75(49):4609–4611. [PubMed] [Google Scholar]
- Collins F. J., Matthews H. R., Baker S. E., Strakova J. M. Drug-induced oesophageal injury. Br Med J. 1979 Jun 23;1(6179):1673–1676. doi: 10.1136/bmj.1.6179.1673. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Evans K. T., Roberts G. M. Where do all the tablets go? Lancet. 1976 Dec 4;2(7997):1237–1239. doi: 10.1016/s0140-6736(76)91158-2. [DOI] [PubMed] [Google Scholar]
- Fellows I. W., Ogilvie A. L., Atkinson M. Oesophageal stricture associated with emepronium bromide therapy. Postgrad Med J. 1982 Jan;58(675):43–44. doi: 10.1136/pgmj.58.675.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Robert A., Nezamis J. E., Lancaster C., Hanchar A. J. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology. 1979 Sep;77(3):433–443. [PubMed] [Google Scholar]