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. 1982 Oct 30;285(6350):1231–1232. doi: 10.1136/bmj.285.6350.1231

Fibronectin in fulminant hepatic failure.

J Gonzalez-Calvin, M F Scully, Y Sanger, J Fok, V V Kakkar, R D Hughes, A E Gimson, R Williams
PMCID: PMC1499786  PMID: 6812819

Abstract

Thirteen out of 17 patients with fulminant hepatic failure had plasma fibronectin concentrations below the normal range (194--472 micrograms/ml), the mean concentration in all 17 patients being 117.9 +/- SE 19.4 micrograms/ml. There was a significant negative correlation between plasma fibronectin concentration and aspartate aminotransferase activity, suggesting that fibronectin is consumed during clearance of hepatocyte debris. The reduced availability of fibronectin may be an important factor in the impaired function of Kuppfer cells in patients with fulminant hepatic failure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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