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. 1982 Dec 11;285(6356):1717–1719. doi: 10.1136/bmj.285.6356.1717

Oesophageal transit of six commonly used tablets and capsules.

H Hey, F Jørgensen, K Sørensen, H Hasselbalch, T Wamberg
PMCID: PMC1500648  PMID: 6816343

Abstract

The oesophageal transit of six commonly used tablets and capsules containing barium sulphate was evaluated radiologically using fluoroscopy in 121 healthy volunteers. To determine the influence of the subject's position and the amount of water taken each subject swallowed three preparations while recumbent and standing and with 25 ml or 100 ml of water. Failure of swallowing (defined as oesophageal transit taking more than 90 seconds) occurred in 22% of 726 swallowings, but globus was complained of in only 33% of these. Sixty per cent of the volunteers had difficulty in taking one or more of the preparations. Many preparations adhered to the oesophageal membrane and started to disintegrate in the lower part of oesophagus. It is recommended that subjects should remain standing for at least 90 seconds after taking capsules or tablets and that all preparations should be taken with at least 100 ml of water. Small tablets are swallowed most easily. Liquid forms of medication (suspensions) should be considered for bedridden patients and those who have difficulty in swallowing.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Carlborg B. Biverkningar vid accidentell lösning av läkemedel i esofagus och bronker. Lakartidningen. 1976 Nov 24;73(48):4201–4204. [PubMed] [Google Scholar]
  2. Carlborg B., Kumlien A., Olsson H. Medikamentella esofagusstrikturer. Lakartidningen. 1978 Dec 6;75(49):4609–4611. [PubMed] [Google Scholar]
  3. Channer K. S., Hollanders D. Tetracycline-induced oesophageal ulceration. Br Med J (Clin Res Ed) 1981 Apr 25;282(6273):1359–1360. doi: 10.1136/bmj.282.6273.1359-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Collins F. J., Matthews H. R., Baker S. E., Strakova J. M. Drug-induced oesophageal injury. Br Med J. 1979 Jun 23;1(6179):1673–1676. doi: 10.1136/bmj.1.6179.1673. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cronstedt J., Carling L., Vestergaard P., Berglund J. Oesophageal disease revealed by endoscopy in 1,000 patients referred primarily for gastroscopy. Acta Med Scand. 1978;204(5):413–416. doi: 10.1111/j.0954-6820.1978.tb08464.x. [DOI] [PubMed] [Google Scholar]
  6. Davies P., Roberts M. B., Roylance J. Acute reactions to urographic contrast media. Br Med J. 1975 May 24;2(5968):434–437. doi: 10.1136/bmj.2.5968.434. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Evans K. T., Roberts G. M. The ability of patients to swallow capsules. J Clin Hosp Pharm. 1981 Sep;6(3):207–208. doi: 10.1111/j.1365-2710.1981.tb00994.x. [DOI] [PubMed] [Google Scholar]
  8. Evans K. T., Roberts G. M. Where do all the tablets go? Lancet. 1976 Dec 4;2(7997):1237–1239. doi: 10.1016/s0140-6736(76)91158-2. [DOI] [PubMed] [Google Scholar]
  9. Funch-Jensen P., Jacobsen E. Esophageal peristalsis before, during, and after food intake in healthy people. Scand J Gastroenterol. 1981;16(2):209–212. doi: 10.3109/00365528109181957. [DOI] [PubMed] [Google Scholar]
  10. Hey H., Matzen P., Andersen J. T., Didriksen E., Nielsen B. A gastroscopic and pharmacological study of the disintegration time and absorption of pivampicillin capsules and tablets. Br J Clin Pharmacol. 1979 Sep;8(3):237–242. doi: 10.1111/j.1365-2125.1979.tb01008.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hey H., Matzen P. Ovre dyspepsi efter perorale laegemidler. Ugeskr Laeger. 1979 Oct 29;141(44):3053–3054. [PubMed] [Google Scholar]
  12. Ivie G. W., Holt D. L., Ivey M. C. Natural toxicants in human foods: psoralens in raw and cooked parsnip root. Science. 1981 Aug 21;213(4510):909–910. doi: 10.1126/science.7256284. [DOI] [PubMed] [Google Scholar]
  13. McCloy E. C., Kane S. Drug-induced oesophageal ulceration. Br Med J (Clin Res Ed) 1981 May 23;282(6277):1703–1703. doi: 10.1136/bmj.282.6277.1703-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Mørck H. I., Nielsen V. M., Kirkegaard P. Ulcus esophagei forårsaget af emeproniumbromid (Cetiprin). Ugeskr Laeger. 1981 Mar 2;143(10):623–623. [PubMed] [Google Scholar]
  15. PRAETORIUS E., FABER J. H. Om tabletters henfald og passage gennem oesophagus og ventrikel; med henblik pa resorption af analgetica og indsovningsmidler. Ugeskr Laeger. 1950 May 4;112(18):628–631. [PubMed] [Google Scholar]
  16. RODIGHIERO G., ALLEGRI G. [Research on the bergaptene content of celery and parsley]. Farmaco Sci. 1959 Oct;14:727–733. [PubMed] [Google Scholar]

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