Abstract
Two hundred and fifty biopsy specimens from the contralateral testis in patients with unilateral germinal testicular cancer were analysed by light microscopy for carcinoma-in-situ changes. Changes were found in 13 (5.2%) patients. One-third of patients with an atrophic contralateral testis (volume less than or equal to 12 ml) and one-fifth of patients with a history of cryptorchidism had changes in the remaining testis. In the present series 85% of cases with carcinoma-in-situ changes would have been diagnosed if the one-fifth of the patients having an atrophic testis or a history of cryptorchidism or both had been screened. Since the natural course of carcinoma in situ in the contralateral testis of patients with germinal testicular cancer has not been established, the patients are being re-evaluated frequently. To date two patients with carcinoma in situ have developed a second cancer.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Batata M. A., Chu F. C., Hilaris B. S., Whitmore W. F., Golbey R. B. Testicular cancer in cryptorchids. Cancer. 1982 Mar 1;49(5):1023–1030. doi: 10.1002/1097-0142(19820301)49:5<1023::aid-cncr2820490528>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
- Berthelsen J. G., Skakkebaek N. E., Mogensen P., Sørensen B. L. Incidence of carcinoma in situ of germ cells in contralateral testis of men with testicular tumours. Br Med J. 1979 Aug 11;2(6186):363–364. doi: 10.1136/bmj.2.6186.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rowley M. J., Heller C. G. The testicular biopsy: surgical procedure, fixation, and staining technics. Fertil Steril. 1966 Mar-Apr;17(2):177–186. doi: 10.1016/s0015-0282(16)35883-6. [DOI] [PubMed] [Google Scholar]
- Skakkebaek N. E. Carcinoma in situ of the testis: frequency and relationship to invasive germ cell tumours in infertile men. Histopathology. 1978 May;2(3):157–170. doi: 10.1111/j.1365-2559.1978.tb01706.x. [DOI] [PubMed] [Google Scholar]
- Skakkebaek N. E. Possible carcinoma-in-situ of the testis. Lancet. 1972 Sep 9;2(7776):516–517. doi: 10.1016/s0140-6736(72)91909-5. [DOI] [PubMed] [Google Scholar]
- Sokal M., Peckham M. J., Hendry W. F. Bilateral germ cell tumours of the testis. Br J Urol. 1980 Apr;52(2):158–162. doi: 10.1111/j.1464-410x.1980.tb02947.x. [DOI] [PubMed] [Google Scholar]