Table 1.
Pharmacokinetic Parameters in Rats.
| Dosing (mg/kg) | Vc (ml/kg | Vss (ml/kg) | Cl (ml/kg per day) | MRT (hours) | α (hours) | β (days) |
| 0.5, i.v. | 49.2±2.9 | 108±7 | 4.43±0.33 | 24.5±1.5 | 12.9±6.2 | 17.7±0.9 |
| 50, i.v. | 75.2±8.1 | 114±9 | 4.56±0.37 | 25.0±0.8 | 5.85±0.90 | 17.4±0.6 |
| Dosing (mg/kg) | Tmax (hours) | Cmax (µg/ml) | Cl (ml/kg per day) | MRT (hours) | α (hours) | β (days) |
| 5.0, s.c. | 4.94±0.41 | 21.5±0.7 | 7.95±0.43 | 25.9±1.2 | 29.4±3.5 | 16.7±0.8 |
Vc, volume of distribution of the central compartment; Vss, steady state volume of distribution; Cl, clearance; MRT, mean residence time; α, alpha-phase half-life; β, beta-phase half-life; Fβ, fraction of clearance attributable to the beta-phase half-life; Tmax, time to maximal concentration; Cmax, maximal concentration.