Table 1.
Tumor Subline | Size | Number | Baseline (21% O2) | Oxygen Challenge (100% O2) | ||||||
pO2 (Torr) | Hypoxic Fractions (%) | pO2 (Torr) | Hypoxic Fractions (%) | |||||||
Mean±SE | Median | HF5 | HF10 | Mean±SE | Median | HF5 | HF10 | |||
H | Small | 6 | 33.8±4.4 | 30.1±4.4 | 9±2 | 16±2 | 137.2±22.9* | 121.1±21.2* | 1±1* | 3±1* |
Large | 6 | 12.7±1.1† | 11.4±1.6† | 31±4† | 46±5† | 83.1±16.2* | 68.5±20.0* | 7±3* | 10±4* | |
AT1 | Small | 7 | 10.4±2.1‡ | 7.9±2.3‡ | 42±7‡ | 61±7‡ | 62.4±13.1*,‡ | 55.4±21.0‡ | 19±7*,‡ | 24±9*,‡ |
Large | 6 | 3.5±1.2†,‡ | 2.1±1.0†,‡ | 65±5†,‡ | 83±3†,‡ | 40.6±20.1 | 23.2±15.5 | 46±11‡ | 59±14‡ |
Small: <1.5 cm3; large: >3 cm3; HF5 or 10: hypoxic fraction (< 5 or 10 Torr).
P<.05 from baseline.
P<.05 from the small group.
P<.05 from the H tumors.