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. 1967 Nov;107(5):391–395.

Experimental Emphysema—Histologic Changes and Alterations in Pulmonary Circulation

Gerald A Brooksby, Boris Datnow, Robert L Dennis, Daniel Clark
PMCID: PMC1503006  PMID: 6083243

Abstract

Detailed study of the pathogenesis of bullous emphysema has been hampered by lack of a suitable animal model of this disease. Prolonged exposure of rats and dogs to elevated partial pressures of oxygen produced a chronic obstructive disease in the lungs of these animals which anatomically resembles bullous emphysema in man. The disease was characterized by extensive bullae formation, alveolar septal destruction, airway obstruction and pronounced circulatory changes. It is suggested that this condition in laboratory animals may serve as a model for the study of pulmonary obstructive disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brooksby G. A., Dennis R. L., Staley R. W. Effects of continuous exposure to rats to 100 per cent oxygen at 450 mm. Hg for 64 days. Aerosp Med. 1966 Mar;37(3):243–246. [PubMed] [Google Scholar]
  2. CLAY J. R., ROSSING R. G. HISTOPATHOLOGY OF EXPOSURE TO PHOSGENE. AN ATTEMPT TO PRODUCE PULMONARY EMPHYSEMA EXPERIMENTALLY. Arch Pathol. 1964 Nov;78:544–551. [PubMed] [Google Scholar]
  3. EISEMAN B., PETTY T., SILEN W. Experimental emphysema. Am Rev Respir Dis. 1959 Jul;80(1 Pt 2):147–152. doi: 10.1164/arrd.1959.80.1P2.147. [DOI] [PubMed] [Google Scholar]
  4. FREEMAN G., HAYDON G. B. EMPHYSEMA AFTER LOW-LEVEL EXPOSURE TO NO2. Arch Environ Health. 1964 Jan;8:125–128. doi: 10.1080/00039896.1964.10663640. [DOI] [PubMed] [Google Scholar]
  5. GOLDSMITH J. R. Epidemiologic studies of obstructive ventilatory disease of the lung. I. A review of concepts and nomenclature. Am Rev Respir Dis. 1960 Oct;82:485–492. doi: 10.1164/arrd.1960.82.4.485. [DOI] [PubMed] [Google Scholar]
  6. HEPPLESTON A. G., LEOPO LD J. G. Chronic pulmonary emphysema: anatomy and pathogenesis. Am J Med. 1961 Aug;31:279–291. doi: 10.1016/0002-9343(61)90116-4. [DOI] [PubMed] [Google Scholar]
  7. LIEBOW A. A. The bronchopulmonary venous collateral circulation with special reference to emphysema. Am J Pathol. 1953 Mar-Apr;29(2):251–289. [PMC free article] [PubMed] [Google Scholar]
  8. McLEAN K. H. The pathogenesis of pulmonary emphysema. Am J Med. 1958 Jul;25(1):62–74. doi: 10.1016/0002-9343(58)90199-2. [DOI] [PubMed] [Google Scholar]
  9. OSWALD N. Chronic bronchitis: some clinical, pathologic, and bacteriologic aspects. Am Rev Tuberc. 1957 Feb;75(2):340–342. doi: 10.1164/artpd.1957.75.2.340. [DOI] [PubMed] [Google Scholar]
  10. QUIGLEY M. B., LEATHERS J. E., REEVES J. T. MICRORADIOGRAPHY OF THE PULMONARY MICROCIRCULATION. Anat Rec. 1964 Mar;148:459–465. doi: 10.1002/ar.1091480304. [DOI] [PubMed] [Google Scholar]
  11. STRAWBRIDGE H. T. Chronic pulmonary emphysema (an experimental study). I. Historical review. Am J Pathol. 1960 Aug;37:161–174. [PMC free article] [PubMed] [Google Scholar]
  12. Strawbridge H. T. Chronic Pulmonary Emphysema (an Experimental Study): III. Experimental Pulmonary Emphysema. Am J Pathol. 1960 Oct;37(4):391–411. [PMC free article] [PubMed] [Google Scholar]

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