Abstract
The Wilson-Mikity Syndrome is a newly described respiratory ailment of very premature infants. It is typified by its characteristic clinical course, with onset after a period of well-being, and radiologic findings of coarse infiltrates alternating with cystic changes. At least four cases have occurred in the last two years at the University of California Medical Center, San Francisco. An exemplary case is given. The pathophysiology of the syndrome appears to relate primarily to abnormal ventilation perfusion relationships resulting from uneven lung compliance. It is suggested that the syndrome results from a distortion of the normal development of the fetal lung.
Full text
PDF






Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AGOSTONI E. Volume-pressure relationships of the thorax and lung in the newborn. J Appl Physiol. 1959 Nov;14:909–913. doi: 10.1152/jappl.1959.14.6.909. [DOI] [PubMed] [Google Scholar]
- Aherne W. A., Cross K. W., Hey E. N., Lewis S. R. Lung function and pathology in a premature infant with chronic pulmonary insufficiency (Wilson-Mikity syndrome). Pediatrics. 1967 Dec;40(6):962–974. [PubMed] [Google Scholar]
- BAGHDASSARIAN O. M., AVERY M. E., NEUHAUSER E. B. A form of pulmonary insufficiency in premature infants. Pulmonary dysmaturity? Am J Roentgenol Radium Ther Nucl Med. 1963 May;89:1020–1031. [PubMed] [Google Scholar]
- BUCHER U., REID L. Development of the intrasegmental bronchial tree: the pattern of branching and development of cartilage at various stages of intra-uterine life. Thorax. 1961 Sep;16:207–218. doi: 10.1136/thx.16.3.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BUTTERFIELD J., MOSCOVICI C., BERRY C., KEMPE C. H. Cystic emphysema in premature infants. A report of an outbreak with the isolation of type 19 ECHO virus in one case. N Engl J Med. 1963 Jan 3;268:18–21. doi: 10.1056/NEJM196301032680104. [DOI] [PubMed] [Google Scholar]
- Boyden E. A., Tompsett D. H. The changing patterns in the developing lungs of infants. Acta Anat (Basel) 1965;61(2):164–192. doi: 10.1159/000142692. [DOI] [PubMed] [Google Scholar]
- Bucci G., Iannaccone G., Scalamandrè A., Savignoni P. G., Mendicini M. Observations on the Wilson-Mikity syndrome. Diffuse cyst-like emphysema of premature infants. Ann Paediatr. 1966;206(2):135–149. [PubMed] [Google Scholar]
- CRAIG J. M. DISTENSIBILITY CURVES AND EXPANSION PATTERNS OF NEWBORN LUNGS. THE UNIQUE PATTERN OF LUNGS OF INFANTS WITH HYALINE MEMBRANES. Am J Dis Child. 1963 Aug;106:174–184. doi: 10.1001/archpedi.1963.02080050176010. [DOI] [PubMed] [Google Scholar]
- FREYCON F., FREYCON M. T. LA MALADIE DE WILSON ET MIKITY. Pediatrie. 1964 Sep;19:773–774. [PubMed] [Google Scholar]
- Fauré C., Grodemange M., Alison F., Sarrut S. L'emphysème bilatéral du prématuré. (Syndrome de Wilson et Mikity) Ann Radiol (Paris) 1966;9(9):731–740. [PubMed] [Google Scholar]
- GWINN J. L., BARNES G. R., Jr RADIOLOGICAL CASE OF THE MONTH. Am J Dis Child. 1965 Jul;110:87–88. doi: 10.1001/archpedi.1965.02090030093014. [DOI] [PubMed] [Google Scholar]
- Grossman H., Berdon W. E., Mizrahi A., Baker D. H. Neonatal focal hyperaeration of the lungs (Wilson-Mikity syndrome). Radiology. 1965 Sep;85(3):409–417. doi: 10.1148/85.3.409. [DOI] [PubMed] [Google Scholar]
- Hodgman J. E., Mikity V. G., Tatter D., Cleland R. S. Chronic respiratory distress in the premature infant. Wilson-Mikity syndrome. Pediatrics. 1969 Aug;44(2):179–195. [PubMed] [Google Scholar]
- Ibrahim J. M., Russell A. Late prolonged respiratory distress syndrome (Wilson-Mikity 1960). Proc R Soc Med. 1966 Jun;59(6):487–489. doi: 10.1177/003591576605900605. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Javett S. N. The Wilson-Mikity syndrome. Case report. Helv Paediatr Acta. 1965 Jul;20(3):325–330. [PubMed] [Google Scholar]
- MITHAL A., EMERY J. L. The postnatal development of alveoli in premature infants. Arch Dis Child. 1961 Aug;36:449–450. doi: 10.1136/adc.36.188.449. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meadows J. A., Jr Two cases of rare causes of respiratory distress in the newborn. 1. Congenital pulmonary lymphangiectasis. 2. Wilson-Mikity syndrome. J Med Assoc State Ala. 1968 Mar;37(9):1039–1044. [PubMed] [Google Scholar]
- NELSON N. M., PRODHOM L. S., CHERRY R. B., LIPSITZ P. J., SMITH C. A. PULMONARY FUNCTION IN THE NEWBORN INFANT. V. TRAPPED GAS IN THE NORMAL INFANT'S LUNG. J Clin Invest. 1963 Dec;42:1850–1857. doi: 10.1172/JCI104869. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Northway W. H., Jr, Rosan R. C., Porter D. Y. Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. N Engl J Med. 1967 Feb 16;276(7):357–368. doi: 10.1056/NEJM196702162760701. [DOI] [PubMed] [Google Scholar]
- OTIS A. B., MCKERROW C. B., BARTLETT R. A., MEAD J., MCILROY M. B., SELVER-STONE N. J., RADFORD E. P., Jr Mechanical factors in distribution of pulmonary ventilation. J Appl Physiol. 1956 Jan;8(4):427–443. doi: 10.1152/jappl.1956.8.4.427. [DOI] [PubMed] [Google Scholar]
- REICH J., HEBER J., SUESS K. J. UBER EINE SELGENE ERKRANKUNG DES FIBROELASTISCHEN LUNGENGERUESTES FRUEHGEBORENER MIT EMPHYSEM. Kinderarztl Prax. 1965 May;33:217–230. [PubMed] [Google Scholar]
- Ringel J., Tomásová J., Hub M. Wilson-Mikity Syndrom, eine spezielle Form der interstitiellen Pneumonie der Frühgeborenen. Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1967;10(1):55–62. [PubMed] [Google Scholar]
- Shepard F. M., Johnston R. B., Jr, Klatte E. C., Burko H., Stahlman M. Residual pulmonary findings in clinical hyaline-membrane disease. N Engl J Med. 1968 Nov 14;279(20):1063–1071. doi: 10.1056/NEJM196811142792001. [DOI] [PubMed] [Google Scholar]
- Sinnette C. H., Bradley-Moore A. M., Cockshott W. P., Edington G. M. Wilson-Mikity respiratory distress syndrome. Arch Dis Child. 1967 Feb;42(221):85–90. doi: 10.1136/adc.42.221.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Swyer P. R., Delivoria-Papadopoulos M., Levison H., Reilly B. J., Balis J. U. The pulmonary syndrome of Wilson and Mikity. Pediatrics. 1965 Sep;36(3):374–384. [PubMed] [Google Scholar]
- Thibeault D. W., Grossman H., Hagstrom J. W., Auld P. A. Radiologic findings in the lungs of premature infants. J Pediatr. 1969 Jan;74(1):1–10. doi: 10.1016/s0022-3476(69)80002-8. [DOI] [PubMed] [Google Scholar]
- Thibeault D. W., Wong M. M., Auld P. A. Thoracic gas volume changes in premature infants. Pediatrics. 1967 Sep;40(3):403–411. [PubMed] [Google Scholar]
- WILSON M. G., MIKITY V. G. A new form of respiratory disease in premature infants. AMA J Dis Child. 1960 Apr;99:489–499. doi: 10.1001/archpedi.1960.02070030491011. [DOI] [PubMed] [Google Scholar]
- Weber J., Tolksdorf M., Althoff H. Das Wilson-Mikity-Syndrom. Klinik, Pathologie und Nosologie. Z Kinderheilkd. 1967;98(4):330–349. [PubMed] [Google Scholar]



