Abstract
A woman who had had high titres of rubella antibodies some months before she became pregnant gave birth to an infant in whom congenital rubella was confirmed at 4 months. Rubella haemagglutination inhibition tests, complement fixation tests, and immunofluorescence tests with anti-human IgG were carried out on sera from the mother. Rubella antibody titres in sera obtained in March 1971, seven and a half months before conception, were equivalent to 400 units, which is usually taken as indicating good immunity. Rubella virus was isolated from the baby's nose and throat in July 1973 but was not isolated from a cervical swab taken from the mother in December 1973; tests of her immunological competence did not show any definite abnormality. The presence of high levels of rubella haemagglutination inhibition antibodies does not invariably confer immunity or exclude the possibility of congenital rubella in a subsequent pregnancy.
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- BRADSTREET C. M., TAYLOR C. E. Technique of complementfixation test applicable to the diagnosis of virus diseases. Mon Bull Minist Health Public Health Lab Serv. 1962 May;21:96–104. [PubMed] [Google Scholar]
- Boué A., Nicolas A., Montagnon B. Reinfection with rubella in pregnant women. Lancet. 1971 Jun 19;1(7712):1251–1253. doi: 10.1016/s0140-6736(71)91775-2. [DOI] [PubMed] [Google Scholar]
- Eilard T., Strannegård O. Rubella reinfection in pregnancy followed by transmission to the fetus. J Infect Dis. 1974 May;129(5):594–596. doi: 10.1093/infdis/129.5.594. [DOI] [PubMed] [Google Scholar]
- Forsgren M., Carlström G., Strangert K. Congenital rubella after maternal reinfection. Scand J Infect Dis. 1979;11(1):81–83. doi: 10.3109/inf.1979.11.issue-1.14. [DOI] [PubMed] [Google Scholar]
- Stewart G. L., Parkman P. D., Hopps H. E., Douglas R. D., Hamilton J. P., Meyer H. M., Jr Rubella-virus hemagglutination-inhibition test. N Engl J Med. 1967 Mar 9;276(10):554–557. doi: 10.1056/NEJM196703092761006. [DOI] [PubMed] [Google Scholar]
- Strannegård O., Holm S. E., Hermodsson S., Norrby R., Lycke E. Case of apparent reinfection with rubella. Lancet. 1970 Jan 31;1(7640):240–241. doi: 10.1016/s0140-6736(70)90595-7. [DOI] [PubMed] [Google Scholar]