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. 1981 Feb 14;282(6263):512–514. doi: 10.1136/bmj.282.6263.512

Plasmatic regulation of vascular prostacyclin in pregnancy.

G Remuzzi, C Zoja, D Marchesi, A Schieppati, G Mecca, R Misiani, M B Donati, G de Gaetano
PMCID: PMC1504327  PMID: 6780103

Abstract

Activity of prostacyclin-stimulating factor was measured in six normal, non-pregnant women, six women in early normal pregnancy, six in late normal pregnancy, and six in late pregnancy complicated by severe pre-eclampsia. The activity was lower in the women in late pregnancy than in those in early pregnancy and the controls but was about normal in those with severe pre-eclampsia. These results may be relevant to the physiology of pregnancy and the pathogenesis of pre-eclampsia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BORN G. V., CROSS M. J. THE AGGREGATION OF BLOOD PLATELETS. J Physiol. 1963 Aug;168:178–195. doi: 10.1113/jphysiol.1963.sp007185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Defreyn G., Dauden M. V., Machin S. J., Vermylen J. A plasma factor in uraemia which stimulates prostacyclin release from cultured endothelial cells. 1980 Aug 15-Sep 1Thromb Res. 19(4-5):695–699. doi: 10.1016/0049-3848(80)90041-9. [DOI] [PubMed] [Google Scholar]
  3. Demers L. M., Gabbe S. G. Placental prostaglandin levels in pre-eclampsia. Am J Obstet Gynecol. 1976 Sep 1;126(1):137–139. doi: 10.1016/0002-9378(76)90478-6. [DOI] [PubMed] [Google Scholar]
  4. Ferris T. F. Postpartum renal insufficiency. Kidney Int. 1978 Oct;14(4):383–392. doi: 10.1038/ki.1978.141. [DOI] [PubMed] [Google Scholar]
  5. Gant N. F., Daley G. L., Chand S., Whalley P. J., MacDonald P. C. A study of angiotensin II pressor response throughout primigravid pregnancy. J Clin Invest. 1973 Nov;52(11):2682–2689. doi: 10.1172/JCI107462. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gerber J. G., Branch R. A., Nies A. S., Gerkens J. F., Shand D. G., Hollifield J., Oates J. A. Prostaglandins and renin release: II. Assessment of renin secretion following infusion of PGI2,E2 and D2 into the renal artery of anesthetized dogs. Prostaglandins. 1978 Jan;15(1):81–88. doi: 10.1016/s0090-6980(78)80006-9. [DOI] [PubMed] [Google Scholar]
  7. Lewis P. J., Boylan P., Friedman L. A., Hensby C. N., Downing I. Prostacyclin in pregnancy. Br Med J. 1980 Jun 28;280(6231):1581–1582. doi: 10.1136/bmj.280.6231.1581. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MacIntyre D. E., Pearson J. D., Gordon J. L. Localisation and stimulation of prostacyclin production in vascular cells. Nature. 1978 Feb 9;271(5645):549–551. doi: 10.1038/271549a0. [DOI] [PubMed] [Google Scholar]
  9. Moncada S., Higgs E. A., Vane J. R. Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation. Lancet. 1977 Jan 1;1(8001):18–20. doi: 10.1016/s0140-6736(77)91655-5. [DOI] [PubMed] [Google Scholar]
  10. Remuzzi G., Cavenaghi A. E., Mecca G., Donati M. B., de Gaetano G. Prostacyclin-like activity and bleeding in renal failure. Lancet. 1977 Dec 10;2(8050):1195–1197. doi: 10.1016/s0140-6736(77)90437-8. [DOI] [PubMed] [Google Scholar]
  11. Remuzzi G., Livio M., Cavenaghi A. E., Marchesi D., Mecca G., Donati M. B., de Gaetano G. Unbalanced prostaglandin synthesis and plasma factors in uraemic bleeding. A hypothesis. Thromb Res. 1978 Sep;13(3):531–536. doi: 10.1016/0049-3848(78)90138-x. [DOI] [PubMed] [Google Scholar]
  12. Remuzzi G., Marchesi D., Zoja C., Muratore D., Mecca G., Misiani R., Rossi E., Barbato M., Capetta P., Donati M. B. Reduced umbilical and placental vascular prostacyclin in severe pre-eclampsia. Prostaglandins. 1980 Jul;20(1):105–110. doi: 10.1016/0090-6980(80)90010-6. [DOI] [PubMed] [Google Scholar]
  13. Remuzzi G., Misiani R., Marchesi D., Livio M., Mecca G., de Gaetano G., Donati M. B. Haemolytic-uraemic syndrome: deficiency of plasma factor(s) regulating prostacyclin activity? Lancet. 1978 Oct 21;2(8095):871–872. doi: 10.1016/s0140-6736(78)91573-8. [DOI] [PubMed] [Google Scholar]
  14. Remuzzi G., Misiani R., Muratore D., Marchesi D., Livio M., Schieppati A., Mecca G., de Gaetano G., Donati M. B. Prostacyclin and human foetal circulation. Prostaglandins. 1979 Sep;18(3):341–348. doi: 10.1016/s0090-6980(79)80052-0. [DOI] [PubMed] [Google Scholar]
  15. Weir R. J., Brown J. J., Fraser R., Kraszewski A., Lever A. F., McIlwaine G. M., Morton J. J., Robertson J. I., Tree M. Plasma renin, renin substrate, angiotensin II, and aldosterone in hypertensive disease of pregnancy. Lancet. 1973 Feb 10;1(7798):291–294. doi: 10.1016/s0140-6736(73)91540-7. [DOI] [PubMed] [Google Scholar]
  16. de Gaetano G., Miragliotta G., Roncucci R., Lansen J., Lambelin G. Suloctidil: a novel inhibitor of platelet aggregation in human beings. Thromb Res. 1976 Mar;8(3):361–371. doi: 10.1016/0049-3848(76)90029-3. [DOI] [PubMed] [Google Scholar]

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