Abstract
Systemic lambda light-chain deposition occurred in a 73-year-old man with myeloma. An initial renal biopsy specimen showed the features of myeloma kidney. When he died 22 months later lambda light chains were detected by immunofluorescence in kidneys, liver, spleen, and heart. They were probably responsible for cardiac dysfunction and the fatal arrhythmia. It is suggested that in this patient deposition was due to a structural alteration of the light chains, possibly induced by cyclophosphamide.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Birshtein B. K., Preud'homme J. L., Scharff M. D. Variants of mouse myeloma cells that produce short immunoglobulin heavy chains. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3478–3482. doi: 10.1073/pnas.71.9.3478. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Herf S., Pohl S. L., Sturgill B., Bolton W. K. An evaluation of diabetic and pseudodiabetic glomerulosclerosis. Am J Med. 1979 Jun;66(6):1040–1045. doi: 10.1016/0002-9343(79)90462-5. [DOI] [PubMed] [Google Scholar]
- Hobbs J. R. Immunocytoma o' mice an' men. Br Med J. 1971 Apr 10;2(5753):67–72. doi: 10.1136/bmj.2.5753.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jensen K. Metabolism of Bence Jones proteins in multiple myeloma patients and in patients with renal disease. Scand J Clin Lab Invest. 1970 Aug;26(1):13–21. doi: 10.3109/00365517009049207. [DOI] [PubMed] [Google Scholar]
- Preud'Homme J. L., Morel-Maroger L., Brouet J. C., Mihaesco E., Mery J. P., Seligmann M. Synthesis of abnormal heavy and light chains in multiple myeloma with visceral deposition of monoclonal immunoglobulin. Clin Exp Immunol. 1980 Dec;42(3):545–553. [PMC free article] [PubMed] [Google Scholar]
- Randall R. E., Williamson W. C., Jr, Mullinax F., Tung M. Y., Still W. J. Manifestations of systemic light chain deposition. Am J Med. 1976 Feb;60(2):293–299. doi: 10.1016/0002-9343(76)90440-x. [DOI] [PubMed] [Google Scholar]
- Sølling K., Sølling J., Jacobsen N. O., Thomsen O. F. Nonsecretory myeloma associated with nodular glomerulosclerosis. Acta Med Scand. 1980;207(1-2):137–143. doi: 10.1111/j.0954-6820.1980.tb09693.x. [DOI] [PubMed] [Google Scholar]
- Wochner R. D., Strober W., Waldmann T. A. The role of the kidney in the catabolism of Bence Jones proteins and immunoglobulin fragments. J Exp Med. 1967 Aug 1;126(2):207–221. doi: 10.1084/jem.126.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]