Skip to main content
NCBI home page
British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1981 Apr 11;282(6271):1194–1195. doi: 10.1136/bmj.282.6271.1194

Effect of radiocontrast media on kidneys of patients with renal disease.

A Rahimi, R P Edmondson, N F Jones
PMCID: PMC1505247  PMID: 6788130

Abstract

A prospective study was undertaken of 15 patients with impaired renal function undergoing x-ray procedures entailing the use of contrast material to see whether any deterioration in renal function resulted. Patients with diabetes or myelomatosis were excluded. Detailed observations were made during three days before and after the x-ray procedure to detect any change in factors such as fluid state, drug treatment, infection, or diet which might have affected renal function. No significant changes occurred in endogenous creatinine and 51Cr-EDTA clearances, or in plasma creatinine and urea concentrations after the x-ray procedures. Furthermore, there was no change in urinary activity of N-acetyl-beta-D-glucosaminidase, which is a highly sensitive indicator of renal parenchymal damage. Provided that fluid depletion and multiple x-ray procedures with radiocontrast material in rapid sequence are avoided, these procedures do not appear to affect renal function adversely, even when renal disease is advanced.

Full text

PDF
1194

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barshay M. E., Kaye J. H., Goldman R., Coburn J. W. Acute renal failure in diabetic patients after intravenous infusion pyelography. Clin Nephrol. 1973 Jan-Feb;1(1):35–39. [PubMed] [Google Scholar]
  2. Byrd L., Sherman R. L. Radiocontrast-induced acute renal failure: a clinical and pathophysiologic review. Medicine (Baltimore) 1979 May;58(3):270–279. doi: 10.1097/00005792-197905000-00006. [DOI] [PubMed] [Google Scholar]
  3. Carrie B. J., Golbetz H. V., Michaels A. S., Myers B. D. Creatinine: an inadequate filtration marker in glomerular diseases. Am J Med. 1980 Aug;69(2):177–182. doi: 10.1016/0002-9343(80)90376-9. [DOI] [PubMed] [Google Scholar]
  4. Defronzo R. A., Humphrey R. L., Wright J. R., Cooke C. R. Acute renal failure in multiple myeloma. Medicine (Baltimore) 1975 May;54(3):209–223. doi: 10.1097/00005792-197505000-00003. [DOI] [PubMed] [Google Scholar]
  5. Diaz-Buxo J. A., Wagoner R. D., Hattery R. R., Palumbo P. J. Acute renal failure after excretory urography in diabetic patients. Ann Intern Med. 1975 Aug;83(2):155–158. doi: 10.7326/0003-4819-83-2-155. [DOI] [PubMed] [Google Scholar]
  6. Fulton R. E., Witten D. M., Wagoner R. D. Intravenous urography in renal insufficiency. Am J Roentgenol Radium Ther Nucl Med. 1969 Jul;106(3):623–634. doi: 10.2214/ajr.106.3.623. [DOI] [PubMed] [Google Scholar]
  7. Krumlovsky F. A., Simon N., Santhanam S., del Greco F., Roxe D., Pomaranc M. M. Acute renal failure. Association with administration of radiographic contrast material. JAMA. 1978 Jan 9;239(2):125–127. doi: 10.1001/jama.239.2.125. [DOI] [PubMed] [Google Scholar]
  8. Lavender S., Hilton P. J., Jones N. F. The measurement of glomerular filtration-rate in renal disease. Lancet. 1969 Dec 6;2(7632):1216–1218. doi: 10.1016/s0140-6736(69)90752-1. [DOI] [PubMed] [Google Scholar]
  9. MACEWAN D. W., DUNBAR J. S., NOGRADY M. B. Intravenous pyelography in children with renal insufficiency. Radiology. 1962 Jun;78:893–903. doi: 10.1148/78.6.893. [DOI] [PubMed] [Google Scholar]
  10. Pillay V. K., Robbins P. C., Schwartz F. D., Kark R. M. Acute renal failure following intravenous urography in patients with long-standing diabetes mellitus and azotemia. Radiology. 1970 Jun;95(3):633–636. doi: 10.1148/95.3.633. [DOI] [PubMed] [Google Scholar]
  11. SCHWARTZ W. B., HURWIT A., ETTINGER A. Intravenous urography in the patient with renal insufficiency. N Engl J Med. 1963 Aug 8;269:277–283. doi: 10.1056/NEJM196308082690601. [DOI] [PubMed] [Google Scholar]
  12. Shafi T., Chou S. Y., Porush J. G., Shapiro W. B. Infusion intravenous pyelography and renal function. Effects in patients with chronic renal insufficiency. Arch Intern Med. 1978 Aug;138(8):1218–1221. [PubMed] [Google Scholar]
  13. Tucker S. M., Boyd P. J., Thompson A. E., Price R. G. Automated assay of N-acetyl-beta-glucosaminidase in normal and pathological human urine. Clin Chim Acta. 1975 Jul 23;62(2):333–339. doi: 10.1016/0009-8981(75)90245-4. [DOI] [PubMed] [Google Scholar]
  14. Weinrauch L. A., Healy R. W., Leland O. S., Jr, Goldstein H. H., Kassissieh S. D., Libertino J. A., Takacs F. J., D'Elia J. A. Coronary angiography and acute renal failure in diabetic azotemic nephropathy. Ann Intern Med. 1977 Jan;86(1):56–59. doi: 10.7326/0003-4819-86-1-56. [DOI] [PubMed] [Google Scholar]
  15. Wellwood J. M., Ellis B. G., Price R. G., Hammond K., Thompson A. E., Jones N. F. Urinary N-acetyl- beta-D-glucosaminidase activities in patients with renal disease. Br Med J. 1975 Aug 16;3(5980):408–411. doi: 10.1136/bmj.3.5980.408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Wellwood J. M., Lovell D., Thompson A. E., Tighe J. R. Renal damage caused by gentamicin: a study of the effects on renal morphology and urinary enzyme excretion. J Pathol. 1976 Mar;118(3):171–182. doi: 10.1002/path.1711180307. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal (Clinical research ed.) are provided here courtesy of BMJ Publishing Group

RESOURCES