Skip to main content
PMC home page
British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1981 Apr 11;282(6271):1186–1188. doi: 10.1136/bmj.282.6271.1186

Familial abnormality of erythrocyte cation transport in essential hypertension.

K L Woods, D G Beevers, M West
PMCID: PMC1505265  PMID: 6788127

Abstract

Cation transport across the red-cell membrane was studied in subjects with essential hypertension and their relatives using rubidium-86 as an analogue of potassium. The activity of the ouabain-sensitive sodium-potassium pump was significantly greater in patients with untreated essential hypertension than in controls (p less than 0.001). No clear separation was seen between normotensive and hypertensive subjects. Activity of the sodium-potassium pump was also increased in a proportion of normotensive relatives of subjects with essential hypertension. Rubidium uptake was significantly lower in normotensive black subjects than in normotensive whites, the difference being in a ouabain-resistant pathway of cation transport. These results provide further evidence that a defect in membrane cation transport contributes to the pathogenesis of essential hypertension.

Full text

PDF
1186

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aronson J. K., Grahame-Smith D. G., Hallis K. F., Hibble A., Wigley F. Monitoring digoxin therapy: I. Plasma concentrations and an in vitro assay of tissue response. Br J Clin Pharmacol. 1977 Apr;4(2):213–221. doi: 10.1111/j.1365-2125.1977.tb00697.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bernstein J. C., Israel Y. Active transport of Rb86 in human red cells and rat brain slices. J Pharmacol Exp Ther. 1970 Aug;174(2):323–329. [PubMed] [Google Scholar]
  3. Canessa M., Adragna N., Solomon H. S., Connolly T. M., Tosteson D. C. Increased sodium-lithium countertransport in red cells of patients with essential hypertension. N Engl J Med. 1980 Apr 3;302(14):772–776. doi: 10.1056/NEJM198004033021403. [DOI] [PubMed] [Google Scholar]
  4. Edmondson R. P., Thomas R. D., Hilton P. J., Patrick J., Jones N. F. Abnormal leucocyte composition and sodium transport in essential hypertension. Lancet. 1975 May 3;1(7914):1003–1005. doi: 10.1016/s0140-6736(75)91947-9. [DOI] [PubMed] [Google Scholar]
  5. Garay R. P., Dagher G., Pernollet M. G., Devynck M. A., Meyer P. Inherited defect in a Na+, K-co-transport system in erythrocytes from essential hypertensive patients. Nature. 1980 Mar 20;284(5753):281–283. doi: 10.1038/284281a0. [DOI] [PubMed] [Google Scholar]
  6. Garay R. P., Elghozi J. L., Dagher G., Meyer P. Laboratory distinction between essential and secondary hypertension by measurement of erythrocyte cation fluxes. N Engl J Med. 1980 Apr 3;302(14):769–771. doi: 10.1056/NEJM198004033021402. [DOI] [PubMed] [Google Scholar]
  7. Garay R. P., Meyer P. A new test showing abnormal net Na+ and K+ fluxes in erythrocytes of essential hypertensive patients. Lancet. 1979 Feb 17;1(8112):349–353. doi: 10.1016/s0140-6736(79)92891-5. [DOI] [PubMed] [Google Scholar]
  8. LOVE W. D., BURCH G. E. A comparison of potassium 42, rubidium 86, and cesium 134 as tracers of potassium in the study of cation metabolism of human erythrocytes in vitro. J Lab Clin Med. 1953 Mar;41(3):351–362. [PubMed] [Google Scholar]
  9. Luft F. C., Grim C. E., Fineberg N., Weinberger M. C. Effects of volume expansion and contraction in normotensive whites, blacks, and subjects of different ages. Circulation. 1979 Apr;59(4):643–650. doi: 10.1161/01.cir.59.4.643. [DOI] [PubMed] [Google Scholar]
  10. Patrick J., Edmondson R. P., Hilton P. J., Jones N. F. Erythrocyte sodium/potassium fluxes in hypertension. Lancet. 1979 Mar 24;1(8117):665–666. doi: 10.1016/s0140-6736(79)91103-6. [DOI] [PubMed] [Google Scholar]
  11. Sever P. S., Peart W. S., Davies I. B., Tunbridge R. D., Gordon D. Ethnic differences in blood pressure with observations on noradrenaline and renin. A hospital hypertensive population. Clin Exp Hypertens. 1979;1(6):745–760. doi: 10.3109/10641967909068637. [DOI] [PubMed] [Google Scholar]
  12. Sever P. S., Peart W. S., Meade T. W., Davies I. B., Gordon D. Ethnic differences in blood pressure with observations on noradrenaline and renin. 1. A working population. Clin Exp Hypertens. 1979;1(6):733–744. doi: 10.3109/10641967909068636. [DOI] [PubMed] [Google Scholar]
  13. Wambach G., Helber A., Bönner G., Hummerich W. Natrium-Kalium--Adenosintriphosphatase-Aktivität in Erythrozytenghosts von Patienten mit essentielier Hypertonie. Klin Wochenschr. 1979 Feb 15;57(4):169–172. doi: 10.1007/BF01477404. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal (Clinical research ed.) are provided here courtesy of BMJ Publishing Group

RESOURCES