Abstract
Normochromic or normocytic anaemia is a common side effect of treatment with cisplatin. Two patients treated with cisplatin 100 mg/m2 in combination with vinblastine, bleomycin, and actinomycin D developed haemolytic anaemia. Neither patient had evidence of haemolysis before treatment, and in both cases severe haemolytic anaemia developed after several courses of cisplatin and when the cancer had regressed almost completely. The importance of haemolysis in the development of anaemia after cisplatin treatment has not been investigated fully and further studies are needed.
Full text
PDF

Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Getaz E. P., Beckley S., Fitzpatrick J., Dozier A. Cisplatin-induced hemolysis. N Engl J Med. 1980 Feb 7;302(6):334–335. doi: 10.1056/NEJM198002073020607. [DOI] [PubMed] [Google Scholar]
- Litterst C. L., LeRoy A. F., Guarino A. M. Disposition and distribution of platinum following parenteral administration of cis-dichlorodiammineplatinum(II) to animals. Cancer Treat Rep. 1979 Sep-Oct;63(9-10):1485–1492. [PubMed] [Google Scholar]
- Rothmann S. A., Weick J. K. Cisplatin toxicity for erythroid precursors. N Engl J Med. 1981 Feb 5;304(6):360–360. doi: 10.1056/NEJM198102053040617. [DOI] [PubMed] [Google Scholar]
- Von Hoff D. D., Schilsky R., Reichert C. M., Reddick R. L., Rozencweig M., Young R. C., Muggia F. M. Toxic effects of cis-dichlorodiammineplatinum(II) in man. Cancer Treat Rep. 1979 Sep-Oct;63(9-10):1527–1531. [PubMed] [Google Scholar]
- Williams C. J., Whitehouse J. M. Cis-platinum: a new anticancer agent. Br Med J. 1979 Jun 23;1(6179):1689–1691. doi: 10.1136/bmj.1.6179.1689. [DOI] [PMC free article] [PubMed] [Google Scholar]
