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. 1981 Jun 27;282(6282):2086–2088. doi: 10.1136/bmj.282.6282.2086

Atopy does not predispose to RSV bronchiolitis or postbronchiolitic wheezing.

D G Sims, P S Gardner, D Weightman, M W Turner, J F Soothill
PMCID: PMC1506539  PMID: 6788213

Abstract

Twenty-six 8-year-old children who had had respiratory syncytial virus (RSV) bronchiolitis in infancy and their paired controls underwent skin and blood tests to assess the role of immunodeficiency and atopy in the pathogenesis of RSV bronchiolitis and the wheezing that may follow it. There was no difference between patients and controls in prevalence of atopy; positive results of prick tests to common antigens; eosinophil counts; yeast opsonisation defect; C2 deficiency; IgG, IgA, IgM, and IgE concentrations; or IgE antibody to dermatophagoides, timothy-grass pollen, and cat fur. Those of the children who had had RSV bronchiolitis and who continued to wheeze had a slightly higher mean eosinophil count and levels of IgE antibody to dermatophagoides than those who did not wheeze. Exercise-induced bronchial lability, though higher in patients than controls, did not correlate significantly with eosinophil counts or IgE concentrations. The genetic factors predisposing to RSV bronchiolitis and postbronchiolitic wheezing may differ from those predisposing to atopic asthma, though exclusive breast feeding may protect against both.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Donovan R., Soothill J. F. Immunological studies in children undergoing tonsillectomy. Clin Exp Immunol. 1973 Jul;14(3):347–357. [PMC free article] [PubMed] [Google Scholar]
  2. Downham M. A., Scott R., Sims D. G., Webb J. K., Gardner P. S. Breast-feeding protects against respiratory syncytial virus infections. Br Med J. 1976 Jul 31;2(6030):274–276. doi: 10.1136/bmj.2.6030.274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Godfrey R. C., Griffiths M. The prevalence of immediate positive skin tests to Dermatophagoides pteronyssinus and grass pollen in schoolchildren. Clin Allergy. 1976 Jan;6(1):79–82. doi: 10.1111/j.1365-2222.1976.tb01415.x. [DOI] [PubMed] [Google Scholar]
  4. Godfrey S. Problems peculiar to the diagnosis and management of asthma in children. BTTA Rev. 1974 Mar;4(1):1–16. [PubMed] [Google Scholar]
  5. König P., Godfrey S. Prevalence of exercise-induced bronchial lability in families of children with asthma. Arch Dis Child. 1973 Jul;48(7):513–518. doi: 10.1136/adc.48.7.513. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Levinsky R. J., Harvey B. A., Paleja S. A rapid objective method for measuring the yeast opsonisation activity of serum. J Immunol Methods. 1978;24(3-4):251–256. doi: 10.1016/0022-1759(78)90129-1. [DOI] [PubMed] [Google Scholar]
  7. McIntosh K., Ellis E. F., Hoffman L. S., Lybass T. G., Eller J. J., Fulginiti V. A. The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children. J Pediatr. 1973 Apr;82(4):578–590. doi: 10.1016/S0022-3476(73)80582-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Nye L., Merrett T. G., Landon J., White R. J. A detailed investigation of circulating IgE levels in a normal population. Clin Allergy. 1975 Mar;5(1):13–24. doi: 10.1111/j.1365-2222.1975.tb01832.x. [DOI] [PubMed] [Google Scholar]
  9. Ostergaard P. A. IgA levels and carrier rate of Haemophilus influenzae and beta-haemolytic streptococci in children undergoing tonsillectomy. Acta Pathol Microbiol Scand C. 1976 Aug;84(4):290–298. [PubMed] [Google Scholar]
  10. Soothill J. F., Harvey B. A. Defective opsonization. A common immunity deficiency. Arch Dis Child. 1976 Feb;51(2):91–99. doi: 10.1136/adc.51.2.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Taylor B., Norman A. P., Orgel H. A., Stokes C. R., Turner M. W., Soothill J. F. Transient IgA deficiency and pathogenesis of infantile atopy. Lancet. 1973 Jul 21;2(7821):111–113. doi: 10.1016/s0140-6736(73)93060-2. [DOI] [PubMed] [Google Scholar]
  12. Turner M. W., Brostoff J., Mowbray J. F., Skelton A. The atopic syndrome: in vitro immunological characteristics of clinically defined subgroups of atopic subjects. Clin Allergy. 1980 Sep;10(5):575–584. doi: 10.1111/j.1365-2222.1980.tb02139.x. [DOI] [PubMed] [Google Scholar]
  13. Turner M. W., Mowbray J. F., Harvey B. A., Brostoff J., Wells R. S., Soothill J. F. Defective yeast opsonization and C2 deficiency in atopic patients. Clin Exp Immunol. 1978 Nov;34(2):253–259. [PMC free article] [PubMed] [Google Scholar]

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