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. 1981 Sep 19;283(6294):751–753. doi: 10.1136/bmj.283.6294.751

Oestrogen receptor proteins in malignant and fetal pancreas.

B Greenway, M J Iqbal, P J Johnson, R Williams
PMCID: PMC1506873  PMID: 6791734

Abstract

High levels of high-affinity oestrogen binding were detected in cytosolic and nuclear fractions of tumour tissue from six patients with pancreatic carcinoma. Similar binding was found in fetal but not in normal adult pancreas, making depression of fetal genes a possibility. Specific androgen binding was not detectable. These findings suggest that anti-oestrogen treatment may offer a new approach to the treatment of pancreatic carcinoma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bardin C. W., Catterall J. F. Testosterone: a major determinant of extragenital sexual dimorphism. Science. 1981 Mar 20;211(4488):1285–1294. doi: 10.1126/science.7010603. [DOI] [PubMed] [Google Scholar]
  2. Bojar H., Dreyfürst R., Balzer K., Staib W., Wittliff J. L. Oestrogen-binding components in human renal cell carcinoma. J Clin Chem Clin Biochem. 1976 Nov;14(11):521–526. doi: 10.1515/cclm.1976.14.1-12.521. [DOI] [PubMed] [Google Scholar]
  3. Bonne C., Raynaud J. P. Methyltrienolone, a specific ligand for cellular androgen receptors. Steroids. 1975 Aug;26(2):227–232. doi: 10.1016/s0039-128x(75)80023-7. [DOI] [PubMed] [Google Scholar]
  4. Chamness G. C., McGuire W. L. Scatchard plots: common errors in correction and interpretation. Steroids. 1975 Oct;26(4):538–542. doi: 10.1016/0039-128x(75)90073-2. [DOI] [PubMed] [Google Scholar]
  5. Chaudhuri P. K., Walker M. J., Briele H. A., Beattie C. W., Gupta T. K. Incidence of estrogen receptor in benign nevi and human malignant melanoma. JAMA. 1980 Aug 22;244(8):791–793. [PubMed] [Google Scholar]
  6. Ginsburg M., Greenstein B. D., MacLusky N. J., Morris I. D., Thomas P. J. An improved method for the study of high-affinity steroid binding:-oestradiol binding in brain and pituitary. Steroids. 1974 Jun;23(6):773–792. doi: 10.1016/0039-128x(74)90053-1. [DOI] [PubMed] [Google Scholar]
  7. Hawkins R. A., Roberts M. M., Forrest A. P. Oestrogen receptors and breast cancer: current status. Br J Surg. 1980 Mar;67(3):153–169. doi: 10.1002/bjs.1800670302. [DOI] [PubMed] [Google Scholar]
  8. Iqbal M. J., Johnson M. W. Purification and characterization of human sex hormone binding globulin. J Steroid Biochem. 1979 May;10(5):535–540. doi: 10.1016/0022-4731(79)90216-4. [DOI] [PubMed] [Google Scholar]
  9. Iqbal M. J., Johnson M. W. Study of steroid-protein binding by a novel "two-tier" column employing Cibacron Blue F3G-A-Sepharose 4B. I-Sex hormone binding globulin. J Steroid Biochem. 1977 Sep;8(9):977–983. doi: 10.1016/0022-4731(77)90196-0. [DOI] [PubMed] [Google Scholar]
  10. Jamieson J. D., Ingber D. E., Muresan V., Hull B. E., Sarras M. P., Jr, Maylié-Pfenninger M. F., Iwanij V. Cell surface properties of normal, differentiating, and neoplastic pancreatic acinar cells. Cancer. 1981 Mar 15;47(6 Suppl):1516–1527. doi: 10.1002/1097-0142(19810315)47:6+<1516::aid-cncr2820471413>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  11. Keshgegian A. A., Wheeler J. E. Estrogen receptor protein in malignant carcinoid tumor: a report of 2 cases. Cancer. 1980 Jan 15;45(2):293–296. doi: 10.1002/1097-0142(19800115)45:2<293::aid-cncr2820450216>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  12. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  13. MacFarlane J. K., Fleiszer D., Fazekas A. G. Studies on estrogen receptors and regression in human breast cancer. Cancer. 1980 Jun 15;45(12):2998–3003. doi: 10.1002/1097-0142(19800615)45:12<2998::aid-cncr2820451220>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  14. McClendon J. E., Appleby D., Claudon D. B., Donegan W. L., DeCosse J. J. Colonic neoplasms: tissue estrogen receptor and carcinoembryonic antigen. Arch Surg. 1977 Mar;112(3):240–241. doi: 10.1001/archsurg.1977.01370030012002. [DOI] [PubMed] [Google Scholar]
  15. Namkung P. C., Moe R. E., Petra P. H. Stability of estrogen receptors in frozen human breast tumor tissue. Cancer Res. 1979 Mar;39(3):1124–1125. [PubMed] [Google Scholar]
  16. Sandberg A. A., Rosenthal H. E. Steroid receptors in exocrine glands: the pancreas and prostate. J Steroid Biochem. 1979 Jul;11(1A):293–299. doi: 10.1016/0022-4731(79)90311-x. [DOI] [PubMed] [Google Scholar]
  17. Stedman K. E., Moore G. E., Morgan R. T. Estrogen receptor proteins in diverse human tumors. Arch Surg. 1980 Mar;115(3):244–248. doi: 10.1001/archsurg.1980.01380030004002. [DOI] [PubMed] [Google Scholar]
  18. Stonehill E. H., Bendich A. Retrogenetic expression: the reappearance of embryonal antigens in cancer cells. Nature. 1970 Oct 24;228(5269):370–372. doi: 10.1038/228370a0. [DOI] [PubMed] [Google Scholar]
  19. Topper Y. J., Freeman C. S. Multiple hormone interactions in the developmental biology of the mammary gland. Physiol Rev. 1980 Oct;60(4):1049–1106. doi: 10.1152/physrev.1980.60.4.1049. [DOI] [PubMed] [Google Scholar]

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