Abstract
To study the relation between hyperglycaemia and a change in the concentration of glycosylated haemoglobin (HbA1) blood glucose and HbA1 concentrations were measured during an oral glucose tolerance test and for 120 days afterwards in 20 normal subjects. These measurements showed that a minor degree of hyperglycaemia led to a significant increase in lycosylated haemoglobin concentrations. The increase appeared 10 days after the test, and values remained raised until 30 days and returned to normal 60 days after the test. If such a minor fluctuation of blood glucose can lead to a significant increase in HbA1 concentrations the test may be too sensitive as an index of long-term blood glucose control in diabetics.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bolli G., Cartechini M. G., Compagnucci P., Santeusanio F., Massi-Benedetti M., Calabrese G., Puxeddu A., Brunetti P. Modification of glycosylated haemoglobin concentration during artificial endocrine pancreas treatment of diabetics. Evidence for a short-term effect on HbA 1 (a+b+c) levels. Diabetologia. 1980;18(2):125–130. doi: 10.1007/BF00290488. [DOI] [PubMed] [Google Scholar]
- Bunn H. F., Haney D. N., Kamin S., Gabbay K. H., Gallop P. M. The biosynthesis of human hemoglobin A1c. Slow glycosylation of hemoglobin in vivo. J Clin Invest. 1976 Jun;57(6):1652–1659. doi: 10.1172/JCI108436. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Maquart F. X., Poynard J. P., Borel J. P., Leutenegger M. Evolution of haemoglobin A1c after oral glucose. Lancet. 1978 Aug 19;2(8086):431–432. doi: 10.1016/s0140-6736(78)91907-4. [DOI] [PubMed] [Google Scholar]