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. 1981 Oct 3;283(6296):881–883. doi: 10.1136/bmj.283.6296.881

Pulmonary hypertension and fenfluramine

J G Douglas, J F Munro, A H Kitchin, A L Muir, A T Proudfoot
PMCID: PMC1507127  PMID: 6793158

Abstract

Pulmonary hypertension developed in two women who had been taking fenfluramine for over eight months for weight reduction. On withdrawing the drug symptoms and electrocardiographic evidence of pulmonary hypertension disappeared in both cases. In one patient, however, the evidence recurred after rechallenge with fenfluramine.

These findings are strong evidence that fenfluramine may cause pulmonary hypertension. Hence any patient taking the drug should report immediately any deterioration in exercise tolerance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARRATT-BOYES B. G., WOOD E. H. Cardiac output and related measurements and pressure values in the right heart and associated vessels, together with an analysis of the hemo-dynamic response to the inhalation of high oxygen mixtures in healthy subjects. J Lab Clin Med. 1958 Jan;51(1):72–90. [PubMed] [Google Scholar]
  2. Bourdillon P. D., Oakley C. M. Regression of primary pulmonary hypertension. Br Heart J. 1976 Mar;38(3):264–270. doi: 10.1136/hrt.38.3.264. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Fahlén M., Bergman H., Helder G., Rydén L., Wallentin I., Zettergren L. Phenformin and pulmonary hypertension. Br Heart J. 1973 Aug;35(8):824–828. doi: 10.1136/hrt.35.8.824. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Follath F., Burkart F., Schweizer W. Drug-induced pulmonary hypertension? Br Med J. 1971 Jan 30;1(5743):265–266. doi: 10.1136/bmj.1.5743.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gagnon M. A., Bordeleau J. M., Tétreault L. Fenfluramine: study of its central action through its effects on sleep. Int Z Klin Pharmakol Ther Toxikol. 1969 Jan;2(1):74–82. [PubMed] [Google Scholar]
  6. Gurtner H. P., Gertsch M., Salzmann C., Scherrer M., Stucki P., Wyss F. Häufen sich die primär vasculären Formen des chronischen Cor pulmonale? Schweiz Med Wochenschr. 1968 Oct 12;98(41):1579–contd. [PubMed] [Google Scholar]
  7. Hudson K. D. The anorectic and hypotensive effect of fenfluramine in obesity. J R Coll Gen Pract. 1977 Aug;27(181):497–501. [PMC free article] [PubMed] [Google Scholar]
  8. Kleiger R. E., Boxer M., Ingham R. E., Harrison D. C. Pulmonary hypertension in patients using oral contraceptives. A report of six cases. Chest. 1976 Feb;69(2):143–147. doi: 10.1378/chest.69.2.143. [DOI] [PubMed] [Google Scholar]
  9. Prime F. J. Dangers of certain appetite suppressants. Br Med J. 1969 Jul 19;3(5663):177–177. doi: 10.1136/bmj.3.5663.177-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Steel J. M., Briggs M. Withdrawal depression in obese patients after fenfluramine treatment. Br Med J. 1972 Jul 1;3(5817):26–27. doi: 10.1136/bmj.3.5817.26. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Turtle J. R., Burgess J. A. Hypoglycemic action of fenfluramine in diabetes mellitus. Diabetes. 1973 Nov;22(11):858–867. doi: 10.2337/diab.22.11.858. [DOI] [PubMed] [Google Scholar]

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