Abstract
To assess non-specific bronchial reactivity the effect of inhaling ultrasonically nebulised solutions of distilled water and hypotonic (0.3%), isotonic (0.9%), and hypertonic (2.7%, 3.6%) saline was investigated in 10 asthmatic patients and nine normal subjects. Expired ventilation and the maximum percentage fall in forced expiratory volume in one second (FEV1) were recorded. The sensitivity to the inhaled solutions was determined by measuring the ventilation required to induce a fall in FEV1 of 20% from the prechallenge value. Hypotonic and hypertonic but not isotonic solutions caused a significant fall in FEV1 in the asthmatic subjects. Normal subjects showed no response to either distilled water or 3.6% saline, the only solutions with which they were challenged. The method used for this challenge is rapid, simple, and inexpensive and provides a new means of diagnosing non-immunologically mediated bronchial hyperreactivity.
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Selected References
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- Anderson S. D., Silverman M., König P., Godfrey S. Exercise-induced asthma. Br J Dis Chest. 1975 Jan;69(1):1–39. doi: 10.1016/0007-0971(75)90053-4. [DOI] [PubMed] [Google Scholar]
- Chai H., Farr R. S., Froehlich L. A., Mathison D. A., McLean J. A., Rosenthal R. R., Sheffer A. L., Spector S. L., Townley R. G. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol. 1975 Oct;56(4):323–327. doi: 10.1016/0091-6749(75)90107-4. [DOI] [PubMed] [Google Scholar]
- Cheney F. W., Jr, Butler J. The effects of ultrasonically-produced aerosols on airway resistance in man. Anesthesiology. 1968 Nov-Dec;29(6):1099–1106. doi: 10.1097/00000542-196811000-00004. [DOI] [PubMed] [Google Scholar]
- Curry J. J. COMPARATIVE ACTION OF ACETYL-BETA-METHYL CHOLINE AND HISTAMINE ON THE RESPIRATORY TRACT IN NORMALS, PATIENTS WITH HAY FEVER, AND SUBJECTS WITH BRONCHIAL ASTHMA. J Clin Invest. 1947 May;26(3):430–438. doi: 10.1172/JCI101826. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Deal E. C., Jr, McFadden E. R., Jr, Ingram R. H., Jr, Breslin F. J., Jaeger J. J. Airway responsiveness to cold air and hyperpnea in normal subjects and in those with hay fever and asthma. Am Rev Respir Dis. 1980 Apr;121(4):621–628. doi: 10.1164/arrd.1980.121.4.621. [DOI] [PubMed] [Google Scholar]
- Findlay S. R., Lichtenstein L. M. Basophil "releasability" in patients with asthma. Am Rev Respir Dis. 1980 Jul;122(1):53–59. doi: 10.1164/arrd.1980.122.1.53. [DOI] [PubMed] [Google Scholar]
- Kaliner M., Austen K. F. Cyclic AMP, ATP, and reversed anaphylactic histamine release from rat mast cells. J Immunol. 1974 Feb;112(2):664–674. [PubMed] [Google Scholar]