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. 1981 Nov 21;283(6303):1355–1357. doi: 10.1136/bmj.283.6303.1355

Evidence for a raised concentration of a circulating sodium transport inhibitor in essential hypertension.

G A MacGregor, S Fenton, J Alaghband-Zadeh, N Markandu, J E Roulston, H E de Wardener
PMCID: PMC1507779  PMID: 6274473

Abstract

A cytochemical technique that measures the ability of plasma to stimulate guinea-pig renal glucose-6-phosphate dehydrogenase (G6PD) activity in vitro, which is a marker of its ability to inhibit Na+-K+-adenosine-triphosphatase (Na+-K+-ATPase), was used in 19 patients with essential hypertension and 23 normotensive, healthy subjects. The ability of plasma to stimulate G6PD was significantly greater in the hypertensive patients when they were taking their normal sodium diet than in the normotensive subjects, and was significantly correlated with blood pressure. The ability of plasma to stimulate G6PD was inversely correlated with plasma renin activity in the hypertensive patients and increased with age and sodium intake in the normotensive subjects. These results support the hypothesis that essential hypertension, and also perhaps the increase in blood pressure with age in communities that consume large quantities of salt, is in part due to an increase in a circulating concentration of an inhibitor of Na+-N+-ATPase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blaustein M. P. Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. Am J Physiol. 1977 May;232(5):C165–C173. doi: 10.1152/ajpcell.1977.232.5.C165. [DOI] [PubMed] [Google Scholar]
  2. Chambers D. J., Dunham J., Zanelli J. M., Parsons J. A., Bitensky L., Chayen J. A sensitive bioassay of parathyroid hormone in plasma. Clin Endocrinol (Oxf) 1978 Oct;9(4):375–379. doi: 10.1111/j.1365-2265.1978.tb02223.x. [DOI] [PubMed] [Google Scholar]
  3. Churchill P. C. Possible mechanism of the inhibitory effect of ouabain on renin secretion from rat renal cortical slices. J Physiol. 1979 Sep;294:123–134. doi: 10.1113/jphysiol.1979.sp012919. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DAVIES D. F., SHOCK N. W. Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest. 1950 May;29(5):496–507. doi: 10.1172/JCI102286. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dikstein S. Stimulability, adenosine triphosphatases and their control by cellular redox processes. Naturwissenschaften. 1971 Sep;58(9):439–443. doi: 10.1007/BF00624617. [DOI] [PubMed] [Google Scholar]
  6. Edmondson R. P., MacGregor G. A. Leucocyte cation transport in essential hypertension: its relation to the renin-angiotensin system. Br Med J (Clin Res Ed) 1981 Apr 18;282(6272):1267–1269. doi: 10.1136/bmj.282.6272.1267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fenton S., Somers S., Heath D. A. Preliminary studies with the sensitive cytochemical assay for parathyroid hormone. Clin Endocrinol (Oxf) 1978 Oct;9(4):381–384. doi: 10.1111/j.1365-2265.1978.tb02224.x. [DOI] [PubMed] [Google Scholar]
  8. George C. F., Lewis P. J., Petrie A. Clinical experience with use of ultrasound sphygmomanometer. Br Heart J. 1975 Aug;37(8):804–807. doi: 10.1136/hrt.37.8.804. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gonick H. C., Kramer H. J., Paul W., Lu E. Circulating inhibitor of sodium-potassium-activated adenosine triphosphatase after expansion of extracellular fluid volume in rats. Clin Sci Mol Med. 1977 Oct;53(4):329–334. doi: 10.1042/cs0530329. [DOI] [PubMed] [Google Scholar]
  10. Gruber K. A., Whitaker J. M., Buckalew V. M., Jr Endogenous digitalis-like substance in plasma of volume-expanded dogs. Nature. 1980 Oct 23;287(5784):743–745. doi: 10.1038/287743a0. [DOI] [PubMed] [Google Scholar]
  11. Miall W. E., Lovell H. G. Relation between change of blood pressure and age. Br Med J. 1967 Jun 10;2(5553):660–664. doi: 10.1136/bmj.2.5553.660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Poston L., Sewell R. B., Wilkinson S. P., Richardson P. J., Williams R., Clarkson E. M., MacGregor G. A., de Wardener H. E. Evidence for a circulating sodium transport inhibitor in essential hypertension. Br Med J (Clin Res Ed) 1981 Mar 14;282(6267):847–849. doi: 10.1136/bmj.282.6267.847. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Roulston J. E., MacGregor G. A. Measurement of plasma renin activity by radioimmunoassay after prolonged cold storage. Clin Chim Acta. 1978 Aug 15;88(1):45–48. doi: 10.1016/0009-8981(78)90147-x. [DOI] [PubMed] [Google Scholar]
  14. de Wardener H. E., MacGregor G. A., Clarkson E. M., Alaghband-Zadeh J., Bitensky L., Chayen J. Effect of sodium intake on ability of human plasma to inhibit renal Na+-K+-adenosine triphosphatase in vitro. Lancet. 1981 Feb 21;1(8217):411–413. doi: 10.1016/s0140-6736(81)91792-x. [DOI] [PubMed] [Google Scholar]
  15. de Wardener H. E., MacGregor G. A. Dahl's hypothesis that a saluretic substance may be responsible for a sustained rise in arterial pressure: its possible role in essential hypertension. Kidney Int. 1980 Jul;18(1):1–9. doi: 10.1038/ki.1980.104. [DOI] [PubMed] [Google Scholar]

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