Abstract
The buccal mucosa of 30 patients with recurrent aphthous stomatitis and 15 healthy controls was injured by suture and penetration with a tenaculum and a hypodermic needle and each of the six puncture wounds produced monitored for up to seven days for the development of ulcers. Altogether 26 lesions were induced in 13 patients, whereas none occurred in the controls (p less than 0.001). Sutures caused most of the lesions (15), and those so induced had a mean maximum diameter of 2.3 mm and lasted for an average of four days. Ulcers induced mechanically were clinically indistinguishable from those usually seen in the patients, except that they were generally smaller and healed more quickly. These findings confirm that mechanically induced injury of the oral mucosa may cause ulceration in people susceptible to aphthous stomatitis. Such a procedure may therefore be helpful in identifying subsets of patients.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Classification, pathogenesis and etiology of recurrent oral ulcerative diseases and Behçet's syndrome. J Oral Pathol. 1978;7(6):436–438. doi: 10.1111/j.1600-0714.1978.tb01615.x. [DOI] [PubMed] [Google Scholar]
- Graykowski E. A., Barile M. F., Lee W. B., Stanley H. R., Jr Recurrent aphthous stomatitis. Clinical, therapeutic, histopathologic, and hypersensitivity aspects. JAMA. 1966 May 16;196(7):637–644. doi: 10.1001/jama.196.7.637. [DOI] [PubMed] [Google Scholar]
- Haim S., Sobel J. D., Friedman-Birnbaum R., Lichtig C. Histohogical and direct immunofluorescence study of cutaneous hyperreactivity in Behçet's disease. Br J Dermatol. 1976 Dec;95(6):631–636. doi: 10.1111/j.1365-2133.1976.tb07036.x. [DOI] [PubMed] [Google Scholar]
- Lehner T. Autoimmunity in oral diseases, with special reference to recurrent oral ulceration. Proc R Soc Med. 1968 May;61(5):515–524. doi: 10.1177/003591576806100543. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SPOUGE J. D., DIAMOND H. F. Hypersensitivity reactions in mucous membranes. I. The statistical relationship between hypersensivity diseases and recurrent oral ulcerations. Oral Surg Oral Med Oral Pathol. 1963 Apr;16:412–421. doi: 10.1016/0030-4220(63)90168-3. [DOI] [PubMed] [Google Scholar]